Ketanserin for the treatment of preeclampsia
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Antoinette C. Bolte
Abstract
Objective: To compare maternal and perinatal outcome with the use of either intravenous ketanserin or dihydralazine in treatment of women with preeclampsia.
Methods: The records from January 1989 to January 1997 of all patients receiving intravenous ketanserin or dihydralazine as first line antihypertensive therapy were reviewed and standardized data forms were completed. 315 charts of patients were identified and evaluated for effects on blood pressure, laboratory parameters, maternal and perinatal outcome.
Results: During the study interval 169 patients received ketanserin and 146 dihydralazine. Significantly fewer antepartum (27% versus 38%, p = 0.04) and postpartum (25% versus 39%, p = 0.01) maternal complications were noted in patients receiving ketanserin. Occurrence of HELLP syndrome was significantly lower among patients who received ketanserin (20%) than among those who received dihydralazine (40%, p = 0.0001). Side-effects were reported with significantly higher frequency in patients receiving dihydralazine (60%) as compared to those receiving ketanserin (17%, p < 0.0001). Perinatal outcome was comparable, however, umbilical cord arterial pH values (mean ± SD) were higher with ketanserin compared to dihydralazine ( 7.25 ± 0.07 vs 7.23 ± 0.09, p = 0.038). The incidence of placental abruption was higher in patients receiving dihydralazine (5.5%) versus those receiving ketanserin (0.6%, p = 0.014).
Conclusion: Ketanserin appears to be a better option than dihydralazine for treatment of severe preeclampsia since fewer maternal complications and side-effects were observed in patients receiving ketanserin.
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- Fetal pulse oximetry: current issues
- Ketanserin for the treatment of preeclampsia
- 11β-hydroxysteroid dehydrogenase (11β-HSD-II) activity in human placenta: Its relationship to placental weight and birth weight and its possible role in hypertension
- Cervical incompetence: the use of selective and emergency cerclage
- Detection of cervical immunoglobulin A in normal pregnancy
- 24 hour-CTG monitoring: comparison of normal pregnancies and pregnancies with placenta insufficiency
- Chlamydia trachomatis infection and the risk of perinatal mortality in Hungary
- Respiratory distress in heavier versus lighter twins
- Superior mesenteric artery blood flow velocity in small for gestational age infants of very low birth weight during the early neonatal period
- Longitudinal observation of deterioration of Doppler parameters, computerized cardiotocogram and clinical course in a fetus with growth restriction
- First-trimester ultrasonographic investigation of cardiovascular anatomy in thoracoabdominally conjoined twins
- Low taurine, gamma-aminobutyric acid and carnosine levels in plasma of diabetic pregnant rats: consequences for the offspring
- Spastic diplegia is not associated with intrapartum hypoxia
