The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
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L. A. Ridnour
Abstract
This review addresses many of the chemical aspects of nitrosative stress mediated by N(2)O(3). From a cellular perspective, N(2)O(3) and the resulting reactive nitrogen oxide species target specific motifs such as thiols, lysine active sites, and zinc fingers and is dependant upon both the rates of production as well as consumption of NO and must be taken into account in order to access the nitrosative environment. Since production and consumption are integral parts of N(2)O(3) generation, we predict that nitrosative stress occurs under specific conditions, such as chronic inflammation. In contrast to conditions of stress, nitrosative chemistry may also provide cellular protection through the regulation of critical signaling pathways. Therefore, a careful evaluation of the chemistry of nitrosation based upon specific experimental conditions may provide a better understanding of how the subtle balance between oxidative and nitrosative stress may be involved in the etiology and control of various disease processes.
Copyright © 2004 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
- Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity
- Singlet oxygen-mediated damage to cellular DNA determined by the comet assay associated with DNA repair enzymes
- Functional studies on the ligand-binding domain of Ultraspiracle from Drosophila melanogaster
- Structural destabilization of the recombinant thermophilic TthL11 ribosomal protein by a single amino acid substitution
- Relevance of the kinetic equilibrium of forces to the control of the cell cycle by Ras proteins
- N-linked glycosylation of the human bradykinin B2 receptor is required for optimal cell-surface expression and coupling
- Identification of sialic acids on Leishmania donovani amastigotes
- Induction of lipoprotein lipase gene expression in Chlamydia pneumoniae-infected macrophages is dependent on Ca2+ signaling events
- Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation
- Monitoring human parvovirus B19 virus-like particles and antibody complexes in solution by fluorescence correlation spectroscopy
- In vitro folding and characterization of the p53 DNA binding domain
