Potential New Approaches for the Development of Brain Imaging Agents for Single-Photon Applications

Kapitel in diesem Buch

1. Frontmatter I
2. Preface V
3. Contents VII
4. I. Basic Research
5. Pharmacology of Amphetamines 3
6. Labelling of Amphetamines with ¹²³I 11
7. Receptors for Amphetamines 19
8. Metabolism of Amphetamines 25
9. New Amphetamine Derivatives 35
10. Biokinetics of N-Isopropyl,p-123I-Iodoamphetamine in the Human 45
11. ²°¹ TI-Diethyldithiocarbamate as an Alternative for ¹²³I-Amphetamine in Brain Imaging with SPECT 51
12. Development of a Lipophilic 99mTc Complex Useful for Brain Perfusion Evaluation with Conventional SPECT Imaging Equipment 59
13. Potential New Approaches for the Development of Brain Imaging Agents for Single-Photon Applications 71
14. Performance of a Multidetector Brain Scanner Compared to a Rotating Gamma Camera System for the Same Scan Task 85
15. IMP SPECTwith the Pinhole Collimator 97
16. II. Clinical Results
17. Clinical Relevance of N-Isopropyl-(¹²³I)p-Iodoamphetamine (IMP) SPECT Brain Imaging 109
18. Regional iodoamphetamine (¹²³I-IMP) Uptake (SPECT) and Regional Cerebral Blood Flow (¹³³Xe-DSPECT) 127
19. Regional Quantification of SPECT-Studies of the Brain with N-Isopropyl-[¹²³I]p-Iodo-Amphetamine (IMP) 139
20. Brain SPECT with ¹²³I-Labelled Amphetamine Derivatives in Epilepsy and Migraine 149
21. IMP-SPECTand Amino Acid-PET in Brain Tumors 157
22. 123I-p-iodo-Isopropyl Amphetamine for Brain Tumor Diagnosis 167
23. An Early Appraisal of Clinical Results of ¹²³I HIPDMSPECT Studies 171
24. List of contributors 179
25. Author’s index 181
26. Subject index 183