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1. Solubility – definition and basic physicochemical considerations
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David Elder
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Kapitel in diesem Buch
- Frontmatter I
- Contents V
- List of contributors VII
- 1. Solubility – definition and basic physicochemical considerations 1
- 2. Solubility and supersaturation 27
- 3. In Silico methods to predict solubility 71
- 4. How solubility influences bioavailability 113
- 5. Estimation of intraluminal drug solubility 133
- 6. Biorelevant media 149
- 7. The role of solubility to optimize drug substances – a medicinal chemistry perspective 169
- 8. The role of solubility in optimizing drug products – a pharmaceutical development perspective 209
- 9. The relevance of solid-state forms for solubility 229
- 10. Solubility and phase behaviour from a drug substance manufacturing perspective 259
- 11. Biowaivers 319
- List of Abbreviations 353
- Index 357
Kapitel in diesem Buch
- Frontmatter I
- Contents V
- List of contributors VII
- 1. Solubility – definition and basic physicochemical considerations 1
- 2. Solubility and supersaturation 27
- 3. In Silico methods to predict solubility 71
- 4. How solubility influences bioavailability 113
- 5. Estimation of intraluminal drug solubility 133
- 6. Biorelevant media 149
- 7. The role of solubility to optimize drug substances – a medicinal chemistry perspective 169
- 8. The role of solubility in optimizing drug products – a pharmaceutical development perspective 209
- 9. The relevance of solid-state forms for solubility 229
- 10. Solubility and phase behaviour from a drug substance manufacturing perspective 259
- 11. Biowaivers 319
- List of Abbreviations 353
- Index 357
