Targeting neurodegenerative diseases: Drug discovery in a challenging arena

Artikel in diesem Heft

1. Preface
2. Analogue-based drug discovery: Contributions to medicinal chemistry principles and drug design strategies. Microtubule stabilizers as a case in point (Special Topic Article)
3. Targeting neurodegenerative diseases: Drug discovery in a challenging arena
4. An acyl-Claisen approach to the synthesis of lignans and substituted pyrroles
5. Spiroketals: Toward the synthesis of 39-oxobistramide K
6. Designer chiral phase-transfer catalysts for green sustainable chemistry
7. Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds
8. Stereoselective construction of 5,11-methanomorphanthridine and 5,10b-phenanthridine structural frameworks: Total syntheses of (±)-pancracine, (±)-brunsvigine, (±)-maritidine, and (±)-crinine
9. New strategies for natural products containing chroman spiroketals
10. Radical azidation reactions and their application in the synthesis of alkaloids
11. Total synthesis of gelsemoxonine
12. Chiral 2,6-bis(5',5'-diphenyloxazoline)pyridine as an efficient ligand for asymmetric catalysis
13. Dynamic boronic acid-mediated autoligation of DNA strands
14. Names and symbols of the elements with atomic numbers 114 and 116 (IUPAC Recommendations 2012)