Volume 26, Issue 2

No abstract available

Nickel, a naturally occurring element that exists in various mineral forms, is mainly found in soil and sediment, and its mobilization is influenced by the physicochemical properties of the soil. Industrial sources of nickel include metallurgical processes such as electroplating, alloy production, stainless steel, and nickel-cadmium batteries. Nickel industries, oil- and coal-burning power plants, and trash incinerators have been implicated in its release into the environment. In humans, nickel toxicity is influenced by the route of exposure, dose, and solubility of the nickel compound. Lung inhalation is the major route of exposure for nickel-induced toxicity. Nickel can also be ingested or absorbed through the skin. The primary target organs are the kidneys and lungs. Other organs such as the liver, spleen, heart, and testes can also be affected to a lesser extent. Although the most common health effect is an allergic reaction, research has also demonstrated that nickel is carcinogenic to humans. The focus of the present review is on recent research concerning the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity. We first present a background on the occurrence of nickel in the environment, human exposure, and human health effects.

Aims: To review the literature on infectious diseases and meteorological and climate change risk factors in the New Zealand context and to describe a tentative research agenda for future work. Methods: We performed literature searches in May 2010 using Medline and Google Scholar. We also searched five health-related government agencies in New Zealand for documentation on climate change and health. Results: The effect of climate variability and change on vector-borne disease has been considered in more detail than any other infectious disease topic (n=20+ journal articles and reports relating to New Zealand). Generally, concern has arisen around the risk of new mosquito incursions and increased risks of dengue and Ross River fevers in the long term. For enteric diseases, the picture from five New Zealand publications is somewhat mixed, although the data indicate that salmonellosis notifications increase with higher monthly temperatures. One interpretation of the New Zealand data is that communities without reticulated water supplies could be more vulnerable to the effects of climate change-mediated increases in protozoan diseases. This information informed a tentative research agenda to address research gaps. Priorities include the need for further work on a more integrated surveillance framework, vector-borne diseases, enteric diseases, skin infections, and then work on topics for which we found no published New Zealand work (such as influenza and leptospirosis). Finally, we found that health-related government agencies in New Zealand have relatively little ‘climate change and health’ information on their websites. Conclusions: Although some informative work has been done to date, much scope remains for additional research and planning to facilitate prevention, mitigation, and adaptation responses in the New Zealand setting around climate change and infectious disease risks. The tentative research agenda produced could benefit from a wider critique, and government agencies in New Zealand could contribute to informed discussions by better documenting the current state of knowledge on their websites.

Objective: To review the literature concerning the risks associated with the main xenobiotics contained in military ammunition and explosive residues and damage to human and environmental health. Methodology: Using “ammunition”, “military”, “environmental”, “health”, “explosive”, “metal”, “TNT”, “RDX”, “pollution”, and “contamination” as search terms, a large database, namely ISI Web of Knowledge SM and PubMed, was searched for studies on military ammunition and explosive residues from 1989 to 2010. Other sources used to conduct the search included the library of the Toxicology Laboratory of the Center for Workers’ Health and Human Ecology (CESTEH) at the National School of Public Health. Results: In total, 15 different combinations were used with the search words above and 708 papers were found. Among them, 76 papers concerned this review. More than 12 references of interest were discovered in the library of the CESTEH. The results were organized into metals, dinitrotoluene, trinitrotoluene (TNT), and royal demolition explosive (RDX), showing their main uses, occurrence in the environment, the current toxic effects to human and environmental health, and remediation possibilities. Conclusion : Because military activities can cause the acute and chronic exposure of human beings, the public administration must aim politics towards suitable environmental management.

Ecologic studies of the spatial relationship between disease and sources of environmental contamination can help to ascertain the degree of risk to populations from contamination and to inform legislation to ameliorate the risk. Population risks associated with persistent low-level mercury exposure have recently begun to be of concern and current reports implicate environmental mercury as a potential contributor in the etiology of various developmental and neurodegenerative diseases including autism and Alzheimer’s disease. In this demonstration of preliminary findings, we demonstrate for Bexar County Texas and Santa Clara County California, the hypothesis that the spatial structure of the occurrence of autism has a positive co-variation with the spatial structure of the distribution of mercury in ambient air. The relative risk of autism is greater in the geographic areas of higher levels of ambient mercury. We find that the higher levels of ambient mercury are geographically associated with point sources of mercury emission, such as coal-fired power plants and cement plants with coal-fired kilns. Although this does not indicate a cause, these results should not be dismissed, but rather seen as a preliminary step for generating a hypothesis for further investigation.

Purpose : Numerous studies have found that either living or attending school near highways or exposure to pollutants associated with heavy motor vehicle traffic are associated with a high prevalence of asthma and reduced lung function. Yet, few investigations have assessed school and home exposure in the same study. Methods: We recruited children aged 5–19 years from a pediatric clinic in an urban center (Boston Chinatown) for many of whom housing and school were located immediately adjacent to two major highways. A questionnaire was used to assess self-report of diagnosis of asthma and the proximity of schools and homes to highways, as well as basic demographic information. Spirometric lung function data were obtained and reviewed by a pediatric pulmonologist blinded to survey responses. During this review, we excluded lung function tests of low quality. Results : The analyses did not demonstrate any associations or mean differences between near-highway exposure at school, at home, or both with diagnosed asthma (p>0.10, n=124). For the lung function data (n=87), neither direct measures (FEV 1 , FVC, and FEF 25–75 ) nor ratio measures (FEV 1 /FVC and FEF 25–75 /FVC) had a significant association with near-highway exposure (p>0.10). Certain predisposing factors, such as diagnosed allergies and family history of asthma, were strongly associated with diagnosed asthma (p<0.05 and p=0.001, respectively), findings we have seen consistently in other work with children recruited from the same clinic. We also found that exposure to pests was significantly correlated with a smaller FEF 25–75 /FVC ratio (p=0.02). Conclusions : Our findings suggest that either limitations in our study design restricted our ability to see the associations reported by others or that such associations do not exist in this population. One possibility is that in this community, with heavy street traffic and many street canyons, the gradient of exposure next to the highway is not very well delineated by simple proximity.

We undertook this study to identify the risk factors and prevalence of Cryptosporidium spp. in HIV-positive and HIV-negative diarrhea patients in the Alice rural settlement in the Eastern Cape Province of South Africa. A total of 180 stool specimens (35 HIV-positive diarrhea, 125 HIV-negative diarrhea patients, and 20 apparently healthy subjects) were screened for cryptosporidiosis using an ELISA-based approach. Sociodemographic information, water supply, and animal contact were recorded for diarrhea-positive patients. The data were analyzed using Pearson’s χ 2 -test and Fisher’s exact test. Cryptosporidium antigen was detected in 122 of 180 specimens (overall prevalence=67.8%). In HIV-positive diarrhea patients, the age groups 31–43 years (mean age 36.5 years) and 70–82 years (mean age 75.8 years) had a higher prevalence (100%) of the antigen than age groups 18–30 years (mean age 23.2 years) and 83–95 years (mean age 88.8 years) (50.0%). In HIV-negative diarrhea patients, the prevalence was highest (87.5%) at ages 18–30 years (mean age 23.2 years) and lowest (35.7%) at ages 83–95 years (mean age 88.8 years). Cryptosporidium antigenemia was slightly higher in females (78.2%, mean age 46.7 years) than in males (71.1%, mean age 42.6 years), but the difference was not significant (p>0.05). No apparently healthy control subject was infected with Cryptosporidium . HIV-negative patients had a significantly higher prevalence of antigen than HIV-positive patients, with farm animals considered a possible risk factor. In HIV-positive diarrhea patients, the prevalence peak was detected in more low income patients (85.7%) than in high income patients (32%). The high infection rate of specific groups was associated with exposure to a contaminated water supply. The results indicate that Cryptosporidium infection is highly prevalent in adult fecal specimens from the Nkonkobe Municipality, an indication of active infection that is likely to emerge as a major human pathogen in this locality owing to socioeconomic changes that favor transmission.