Volume 41, Issue 3-4

A highly efficient catalytic preparation of 2-amino-5-oxo-4-aryl-4,5-dihydroindeno[1,2-b]pyran-3-carbonitrile derivatives using different metal silicates was developed through a three-component reaction of malononitrile, aromatic aldehydes, and 1,3-indandione in high yields.

In this work, the PbFe 12 O 19 nanoparticles were prepared by the simple and optimized precipitation method with different organic surfactants and capping agents. In the next step, the TiO 2 nanoparticles were synthesized using the sol-gel method. At the final step, the PbFe 12 O 19 -TiO 2 nanocomposites were prepared via the sol-gel method. The effect of the precipitating agent on the morphology and particle size of the products was investigated. The prepared products were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. The results obtained by the vibrating sample magnetometer show the magnetic properties of the ferrite nanostructures. The photocatalytic effect of the PbFe 12 O 19 -TiO 2 nanocomposite on the elimination of the azo dyes (acid black, acid violet and acid blue) under ultraviolet light irradiation was evaluated. The results indicate that the prepared nanocomposites have acceptable magnetic and photocatalytic performance.

Piperazine and tetraone-related compounds are widely used in the drug industry. Heteroatom-doped fullerenes are studied as new types of sensor devices, and medical applications are studied as drug delivery vehicles. In this work, Si- or Al-doped C 60 fullerenes and their interactions with piperazine-2,3,5,6-tetraone (ppto) molecule and some important structural or electronic properties were examined using the density functional theory (DFT). Results indicate that doped C 60 fullerenes might be used to diagnose the presence of ppto as delivery vehicle and sensor because of their high adsorption energies and change of band gap energies.

Fullerenes and heteroatom doped fullerenes exhibit high potential as drug delivery agents in sensor technology and medical applications. We investigated, using density functional theory, the possible interaction sites and the nature of interaction, adsorption energy assessments, band gap energy evaluations, charge transfer analyses, and some diagnostic vibrational band assignments for valproic acid (VPA) and aluminum, silicon, and boron decorated fullerene systems. The present research shows that VPA has strong interaction with the doped fullerene cages particularly at its carbonyl edge. Therefore, these doped fullerenes can be suggested as possible drug delivery agents.

To enhance the performance of anti-coking and anti-sintering of the Ni-based catalysts during the reaction process of CO methanation, we synthesized a group of catalysts denoted as “Ni-xMgAl 2 O 4 ” via the modified co-precipitation method utilizing carbon black as hard template. The addition of carbon black could significantly improve the specific surface area of MgAl 2 O 4 to 235.8 m 2 g −1 . The Ni catalysts supported on high-surface-area MgAl 2 O 4 (Ni-0.25MA) exhibited enhanced catalytic performance and hydrothermal stability in comparison with the conventional Ni-based magnesia alumina spinel catalysts with the same NiO content. In the process of 120-h stability test, the Ni-0.25MA catalyst exhibited remarkable improvement in both anti-sintering and anti-coking. After a series of characterizations, we found that the addition of carbon black could make more pores over MgAl 2 O 4 , resulting in the supported Ni particles being anchored in the pore rather than on the outside surface of support. This structure enhanced the dispersion of nickel nanoparticles, thus strengthening the interaction between nickel species and the MgAl 2 O 4 support, which led to the promotion in catalytic activity and stability of high-surface-area Ni/MgAl 2 O 4 .

FSM-16-SO 3 H nanoparticles were prepared using a sol-gel method at room temperature. The prepared FSM-16-SO 3 H was used to catalyze the synthesis of polyhydroquinolines through a one-pot, four-component reaction of aldehydes, dimedone, ethyl cyanoacetate, and ammonium acetate under reflux condition in EtOH as a green solvent. To investigate the textural properties of the prepared catalyst, various techniques were applied such as X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscope, and Brunauer–Emmett–Teller. High catalytic activity, easy handling, and thermal stability are the superior properties that could be denoted after successive investigations of this catalyst. In addition, the catalyst can be recovered easily and reused effectively for several cycles.

The development of highly selective homogeneous electron transfer reagents is highly desirable for synthetic chemistry. An isolable spirosilole tetra-anion described in this paper has been proved to be a promising soluble electron transfer reagent. The reduction of octaphenyl-1,1′-spirobisilole ( 1 ) with lithium resulted in the formation of the isolable spirosilole tetra-anion in good yield. The tetra-anion ( 2 ) has been characterized by nuclear magnetic resonance (NMR) and cleanly underwent electron transfer reactions with dioxygen, carbonyl groups, and transition metal halides to yield reduction products with the regeneration of 1 .

The syntheses and structures of tert -butylaminomethyl(mesityl)phosphinic acid ethyl ester 2 and its zinc dichloride complex 3 are reported. In the solid state, both compounds are dimeric via hydrogen bridges. In the complex 3 , the phosphinic acid ester 2 coordinates the zinc dichloride diastereoselectively.

In this study, two new metal-organic frameworks, namely, {(H 2 NMe 2 )[Zn 3 LiO(BTA) 2 ](DMF) 3 } n ( 1 , H 3 BTA=3,3′,3″-[1,3,5-benzenetriyltris(carbonylimino)] trisbenzoic acid) and {(Me 2 NH 2 ) 2 [In 2 (TTA) 2 (FBA) 2 ](DMF) 3 } n ( 2 , H 3 TTA=4,4′-(((5-((4-(hydroxy-l2-methoxy)phenoxy) methyl)-2,4,6-trimethyl-1,3-phenylene)bis(methylene))bis(oxy))dibenzoic acid, HFBA=2-fluorobenzoic acid), were obtained via a one-pot solvothermal reaction of metal salts and organic connectors. The structures of the title two metal-organic coordination compounds were structurally probed via X-ray single crystal diffraction technique. In connection to their structures, the MTT assay was used to access the in vitro antitumor activities for compounds 1 and 2 against the human lung cancer cells (MSTO-211H, NCI-H1299 and NCI-H292).

The study of the interaction of drugs with DNA is very exciting and significant not only for understanding the mechanism of the interaction but also for the design of new drugs. Here, we report the results of Fourier transform infrared (FT-IR) and ultraviolet (UV)-visible spectroscopy studies to determine the external binding modes of sulfathiazole (STZ), and the binding constant and stability of the STZ-DNA complex in aqueous solution. The results of absorption spectra showed that the interaction of STZ-DNA is weak because there is only a hyperchromic effect. A hyperchromic effect reflects the corresponding changes of DNA in its conformation and structure after the drug-DNA interaction has occurred. Spectroscopic evidence revealed that STZ binds DNA with an overall binding constant of K (STZ-DNA)=0.42×10 3 m −1 . FT-IR spectroscopy showed that the complexation of STZ with DNA occurred via A-T and PO 2 groups. Nano cadmium hydroxide has been synthesized using hexamine as the template at room temperature. Then, this nano cadmium hydroxide recrystallizes into nano cadmium oxide (CdO) at 400°C for 2 h. The product was characterized by using X-ray diffraction and scanning electron microscopy. The presence of drugs in aquatic media has emerged in the last decade as a new environmental risk. The other aim of this study was to investigate the degradation of the STZ antibiotic by nanosized CdO under ultraviolet irradiation. Various experimental parameters, such as initial CdO concentration, initial pH, and reaction times, were investigated. According to the results, this method has a good performance in the removal of STZ.

Here, a new indium (In)-based coordination polymer [In(hip)](DMF) 2 (H 2 O) 3 ( 1 , DMF=N,N-dimethylformamide) was successfully prepared by a solvothermal reaction of In(NO 3 ) 3 ·6H 2 O and 5-hydroxyisophthalic acid (H 3 hip) in a mixed solvent of DMF and H 2 O with the presence of NaCl as a template. Complex 1 was characterized by elemental analysis (EA), single-crystal X-ray crystallography, and powder X-ray diffraction (PXRD), and the results reveal that complex 1 shows a two-dimensional (2D) grid-like network with considerable solvent accessible volume that was generated from the packing of the 2D layers via the AB pattern. Furthermore, complex 1 could be downsized into nanoscale particles with the aid of polyvinylpyrrolidone (PVP). In addition, the anticancer activities of 1 and the nanoscale 1 were probed via the 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay.