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We study a model where one target variable Y$Y$ is correlated with a vector X:=(X1,…,Xd)$\textbf{X}:=(X_1,\dots,X_d)$ of predictor variables being potential causes of Y$Y$. We describe a method that infers to what extent the statistical dependences between X$\textbf{X}$ and Y$Y$ are due to the influence of X$\textbf{X}$ on Y$Y$ and to what extent due to a hidden common cause (confounder) of X$\textbf{X}$ and Y$Y$. The method relies on concentration of measure results for large dimensions d$d$ and an independence assumption stating that, in the absence of confounding, the vector of regression coefficients describing the influence of each X$\textbf{X}$ on Y$Y$ typically has ‘generic orientation’ relative to the eigenspaces of the covariance matrix of X$\textbf{X}$. For the special case of a scalar confounder we show that confounding typically spoils this generic orientation in a characteristic way that can be used to quantitatively estimate the amount of confounding (subject to our idealized model assumptions).

Linear structural equation models relate the components of a random vector using linear interdependencies and Gaussian noise. Each such model can be naturally associated with a mixed graph whose vertices correspond to the components of the random vector. The graph contains directed edges that represent the linear relationships between components, and bidirected edges that encode unobserved confounding. We study the problem of generic identifiability, that is, whether a generic choice of linear and confounding effects can be uniquely recovered from the joint covariance matrix of the observed random vector. An existing combinatorial criterion for establishing generic identifiability is the half-trek criterion (HTC), which uses the existence of trek systems in the mixed graph to iteratively discover generically invertible linear equation systems in polynomial time. By focusing on edges one at a time, we establish new sufficient and new necessary conditions for generic identifiability of edge effects extending those of the HTC. In particular, we show how edge coefficients can be recovered as quotients of subdeterminants of the covariance matrix, which constitutes a determinantal generalization of formulas obtained when using instrumental variables for identification. While our results do not completely close the gap between existing sufficient and necessary conditions we find, empirically, that our results allow us to prove the generic identifiability of many more mixed graphs than the prior state-of-the-art.

In the causal adjustment setting, variable selection techniques based only on the outcome or only on the treatment allocation model can result in the omission of confounders and hence may lead to bias, or the inclusion of spurious variables and hence cause variance inflation, in estimation of the treatment effect. We propose a variable selection method using a penalized objective function that is based on both the outcome and treatment assignment models. The proposed method facilitates confounder selection in high-dimensional settings. We show that under some mild conditions our method attains the oracle property. The selected variables are used to form a doubly robust regression estimator of the treatment effect. Using the proposed method we analyze a set of data on economic growth and study the effect of life expectancy as a measure of population health on the average growth rate of gross domestic product per capita.

We consider ways of enabling systems to apply previously learned information to novel situations so as to minimize the need for retraining. We show that theoretical limitations exist on the amount of information that can be transported from previous learning, and that robustness to changing environments depends on a delicate balance between the relations to be learned and the causal structure of the underlying model. We demonstrate by examples how this robustness can be quantified.