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Direct Asymmetric Aldol Reactions Catalyzed by Lipase from Porcine Pancreas
-
Jing Zheng
und
Yan-Hong He
Veröffentlicht/Copyright:
2. Juni 2014
Porcine pancreas lipase type II (PPL II) exhibited unnatural catalytic activity in direct asymmetric aldol reactions between cyclic ketones and aromatic or heteroaromatic aldehydes in acetonitrile in the presence of phosphate buffer. A wide range of substrates was accepted by the enzyme to afford the corresponding aldol products in low to high yields (10 - 98%), with moderate to excellent enantioselectivities (53 - 94% ee, for anti-isomers) and low to moderate diastereoselectivities (48/52 - 87/13 dr, anti/syn). This methodology expands the application of PPL II, and it might be developed into a potentially valuable method for sustainable organic synthesis.
Received: 2013-7-25
Revised: 2014-1-26
Published Online: 2014-6-2
Published in Print: 2014-4-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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Artikel in diesem Heft
- A New Ergostane Triterpenoid from a Solid Culture of the Basidiomycete Inocybe lilacina
- Non-Alkaloidal Compounds from the Bulbs of the Egyptian Plant Pancratium maritimum
- In vitro Investigation of Anticancer, Cell-Cycle-Inhibitory, and Apoptosis-Inducing Effects of Diversin, a Natural Prenylated Coumarin, on Bladder Carcinoma Cells
- Antileishmanial Compounds from Moringa oleifera Lam.
- Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella
- The Co-Occurrence of Two Pyridine Alkaloids, Mimosine and Trigonelline, in Leucaena leucocephala
- Aqueous Garlic Extract Alleviates Liver Fibrosis and Renal Dysfunction in Bile-Duct-Ligated Rats
- The Wheat Aquaporin Gene TaAQP7 Confers Tolerance to Cold Stress in Transgenic Tobacco
- Isolation and Characterization of Wild-Type Lipoxygenase LOXPsa1 from Pleurotus sapidus
- Molecular Cloning and Characterization of a Bombyx mori Gene Encoding the Transcription Factor Atonal
- Total Antioxidant Capacity of Feces of Mammalian Herbivores and Carnivores
- Direct Asymmetric Aldol Reactions Catalyzed by Lipase from Porcine Pancreas
