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Catalyst-free, Solvent-promoted and Scalable Multicomponent Synthesis of 3-Aminoalkylated Indoles via a Mannich-type Reaction
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Jian-Fei Cao
Published/Copyright:
June 2, 2014
A catalyst-free, solvent-promoted and scalable three-component Mannich-type reaction of indoles, aromatic aldehydes and secondary amines for the synthesis of 3-(1-dialkylaminoalkyl)-1H-indoles has been developed. The protocol provided a mild, simple and highly atom-economic alternative to prepare the title compounds, and the corresponding products could be obtained in good to excellent yields in most cases.
Graphical Abstract
Catalyst-free, Solvent-promoted and Scalable Multicomponent Synthesis of 3-Aminoalkylated Indoles via a Mannich-type Reaction
Received: 2013-11-14
Published Online: 2014-6-2
Published in Print: 2014-6-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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Keywords for this article
Solvent-promoted;
Scalable;
Multicomponent Synthesis;
3-Aminoalkylated Indoles
Articles in the same Issue
- Synthesis and Crystal Structure of a “High-temperature” Phase of Li[H2NC(O)NH], the Missing Alkali-Metal Ureate
- Strukturen von polaren Magnesiumorganylen: Synthese und Struktur von Basen-Addukten des Bis(pentamethylcyclopentadienyl)magnesiums
- The Mixed-valent Mercury(I/II) Compounds Hg3(HAsO4)2 and Hg6As2O10
- New Intermetallic Zinc Compounds with Ordering Variants of the KHg2 and LT-SrZn5 Type
- Effects of Metal Ions and N-Donor Ligands with Different Coordination Characters on the Construction of d10 Metal-organic Complexes with Selective Photocatalytic Activities
- Synthesis and Characterization of Novel Re(BIAN)(CO)3Cl Derivatives Including the First Example of a Water-soluble Tricarbonyl Rhenium(I) Complex with Bis(imino)acenaphthene Ligands
- Hydrothermal Synthesis and Crystal Structure of a One-dimensional Cobalt (II) Coordination Polymer with Two Organic Ligands
- Vinylsilylferrocenes and Ethynyl(vinyl)silylferrocenes. Synthesis, Multinuclear Magnetic Resonance Study and DFT Calculations
- One-pot Multi-component Synthesis of Mono- and Bis-indolylimidazole Derivatives Using Zn2+@KSF and Their Antibacterial Activity
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- Synthesis and Reactions of New Chiral Linear Dipeptide Candidates Using Nalidixic Acid as Starting Material
- Synthesis and Characterization of Ammonium Acesulfamate
- Two Rare Hydroazulene-type Sesquiterpenes from the Roots of Aristolochia yunnanensis
- Spiroalkaloids and Coumarins from the Stem Bark of Pauridiantha callicarpoides
