Peto’s Paradox

Chapters in this book

1. Frontmatter i
2. Contents vii
3. Foreword ix
4. Introduction 1
5. The Evolution of Life Spans and Disease Avoidance 5
6. Understanding Evolution at Organismal and Somatic Levels 20
7. The Evolution of Multicellularity and Tumor Suppression 31
8. Mechanisms of Tumor Suppression 41
9. Dominant Views of the Mechanisms of Oncogenesis 58
10. Adaptive Oncogenesis 73
11. Limiting Somatic Evolution in Youth 88
12. Changing Adaptive Landscapes with Aging 101
13. Changing Adaptive Landscapes with Carcinogenic Exposures 117
14. Tissue Architecture and Tumor Suppression 134
15. Peto’s Paradox 146
16. Prolonging Tissue Maintenance to Delay Aging and Cancer 157
17. Understanding Clinical Data from an Evolutionary Perspective 175
18. The Causes of Cancer in Early Childhood 195
19. Evolution-Informed Strategies to Combat Cancer 206
20. A New Framework for Understanding and Controlling Cancer 226
21. References 235
22. Acknowledgments 263
23. Index 267