Bioactivity and mechanical properties of scaffolds based on calcium aluminate and bioactive glass
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G. García-Álvarez
Abstract
Scaffolds were developed from mixtures of calcium aluminate (CA) and a bioactive glass (BG) and the effect of glass content on the mechanical strength and bioactivity of scaffolds was studied. Three different mixtures were tested: 95CA-5BG, 92.5CA-7.5BG and 90AC-10BG wt.%. Also, for comparison purposes, pure CA was used. In order to obtain the calcium aluminate cements (CAC), mixtures were hydrated using a water/mixture ratio by weight (w/c) of 0.4 and, with the resulting pastes, scaffolds were made by the lost-spheres method using PMMA beads. These materials showed interconnected pores (215 μm average diameter). Obtained scaffolds were loaded with antibiotic (gentamicin sulfate) and its release kinetics was studied. The evaluation of the in-vitro bioactivity was carried out by immersing scaffolds in a simulated body fluid (SBF) for 1, 7, 14 or 21 days at 36.5 °C. Compressive strength was evaluated before and after each immersion period. In all cases the formation of a Ca,P-rich compound on the surface of the scaffolds was detected after immersion in SBF. The amount of the bioactive compound formed as well as compressive strength increased as the amount of bioglass was increased. A controlled antibiotic release in SBF, with diffusion-controlled kinetics, was observed. In addition, scaffolds were not hemolytic. According to the results obtained, these materials are promising candidates for biomedical applications as drug delivery systems.
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© 2019, Carl Hanser Verlag, München
Artikel in diesem Heft
- Contents
- Contents
- Editorial
- “VII International Congress of Biomaterials, BIOMAT' 2018” (14–16 March 2018, Havana, Cuba): from medical devices to regenerative medicine
- Original Contributions
- Microstructural evolution and strain hardening behavior of AISI 316L type austenitic stainless steel
- The microstructure and three-point bending behavior of Ni–Co/WC composite cladding coating
- Effects of TiN coating on the high-cycle-fatigue and very-high-cycle-fatigue properties of Ti-6Al-4V alloy
- Phase equilibria of the Dy–Nb–Si ternary system at 1 273 K
- Synthesis of SnO/SnO2 microsphere photocatalysts by ultrasonic reaction
- Exploring the use of silica sands and calcite from natural deposits to prepare bioactive glasses
- Bioactivity and mechanical properties of scaffolds based on calcium aluminate and bioactive glass
- Effect of heat treatment on apatite coatings deposited on pre-calcified titanium substrates
- Calcium silicate-poly(n-butyl-2-cyanoacrylate) nanocomposite for bone tissue adhesion
- Synthesis and evaluation of a collagen–brushite cement as a drug delivery system
- Short Communications
- Biomedical porous Ti-16Nb-10Zr-(0–15)Ta alloys
- Influence of Zr addition on the corrosion behavior of biomedical PIM Ti-16Nb alloy in SBF
- DGM News
- DGM News
Artikel in diesem Heft
- Contents
- Contents
- Editorial
- “VII International Congress of Biomaterials, BIOMAT' 2018” (14–16 March 2018, Havana, Cuba): from medical devices to regenerative medicine
- Original Contributions
- Microstructural evolution and strain hardening behavior of AISI 316L type austenitic stainless steel
- The microstructure and three-point bending behavior of Ni–Co/WC composite cladding coating
- Effects of TiN coating on the high-cycle-fatigue and very-high-cycle-fatigue properties of Ti-6Al-4V alloy
- Phase equilibria of the Dy–Nb–Si ternary system at 1 273 K
- Synthesis of SnO/SnO2 microsphere photocatalysts by ultrasonic reaction
- Exploring the use of silica sands and calcite from natural deposits to prepare bioactive glasses
- Bioactivity and mechanical properties of scaffolds based on calcium aluminate and bioactive glass
- Effect of heat treatment on apatite coatings deposited on pre-calcified titanium substrates
- Calcium silicate-poly(n-butyl-2-cyanoacrylate) nanocomposite for bone tissue adhesion
- Synthesis and evaluation of a collagen–brushite cement as a drug delivery system
- Short Communications
- Biomedical porous Ti-16Nb-10Zr-(0–15)Ta alloys
- Influence of Zr addition on the corrosion behavior of biomedical PIM Ti-16Nb alloy in SBF
- DGM News
- DGM News
