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Cyclotron production of 101Pd/101mRh radionuclide generator for radioimmunotherapy

  • M. Enferadi , M. Sadeghi and M. Ensaf
Published/Copyright: April 5, 2013
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Abstract

101mRh is one of such radionuclides that has been considered as a potential candidate for targeted radiotherapeutic use, due to its nuclear decay and chemical properties. Electrodeposition of rhodium metal on a copper backing was performed in acidic sulphate. The target was bombarded with a current intensity of 120 μA (Ep = 29 → 25 MeV) for 30 min (60 μAh). Radiochemical methods were investigated to optimize the production of no-carrier-added 101Pd/101mRh. The use of a cyclotron target with radiochemical processes (i.e. electrodeposition, electrodissolution and ion-exchange column chromatography) were carried out to produce this radionuclide in high-specific activity and radiochemical form suitable for radiopharmaceutical syntheses.

Kurzfassung

101mRh ist eines der Radionuklide, die wegen ihres Kernzerfalls und ihrer chemischen Eigenschaften als potentielle Kandidaten für eine gezielte Strahlentherapie in Frage kommen. Die Elektrodeposition von Rhodiummetall auf einem Kupferträger wurde in saurem Sulphat durchgeführt. Das Target wurde bombardiert mit einer Stromstärke von 120 μA (Ep = 29 → 25 MeV) für 30 min (60 μAh). Radiochemische Methoden wurden untersucht, um die Herstellung von trägerfreiem 101Pd/101mRh zu optimieren. Mit Hilfe eines Zyklotron-Targets und entsprechender radiochemischer Prozesse (wie z.B. Elektrodeposition, elektrolytische Auflösung und Ionenaustausch-Säulenchromatographie) wurde dieses Radionuklid mit hoher spezifischer Aktivität hergestellt in einer radiochemischen Form, die für die radiopharmazeutische Synthese geeignet ist.


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Received: 2010-9-13
Published Online: 2013-04-05
Published in Print: 2011-05-01

© 2011, Carl Hanser Verlag, München

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