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Thermodynamic Solution Properties of Benzalkonium Chloride in Aqueous and Ethanolic Media and its Interactions with Organized Assemblies of Anionic Surfactant Sodium Dodecyl Sulphate and Amino Acids

Published/Copyright: March 11, 2016
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Abstract

This manuscript reports the physicochemical behaviour of antimicrobial cationic surfactant benzalkonium chloride (BAC) as well as its interaction with the anionic surfactant sodium dodecyl sulfate in term of mixed micelle. Surface activity of pure BAC was studied by measuring the surface parameters i. e. surface pressure (Π), surface excess concentration (Γ), area per molecule and standard Gibbs free energy of adsorption (ΔGads). The electrical conductivity was measured to calculate the thermodynamic parameters like free energy of micellization, ΔGm, enthalpy of micellization, ΔHm and entropy of micellization, ΔSm. The interaction of the drug with sodium dodecyl sulfate was studied, in term of mixed micelle, by electrical conductivity and UV/Visible spectroscopy. Spectroscopic method helps to calculate the partition coefficient (Kx) and free energy of partition, while the conductivity method is helpful to calculate thermodynamic parameters of their interaction. The effect of different amino acids on CMC of BAC has also been studied.

Kurzfassung

In dieser Arbeit wird über die Eigenschaften des antimikrobiell wirksamen kationischen Tensids Benzalkoniumchlorid (BAC) berichtet sowie über dessen Wechselwirkung mit dem anionischen Tensid Natriumdodecylsulfat in den Mischmizellen. Aussagen über die Oberflächenaktivität von reinem BAC wurden aus Messungen der Oberflächenparameter wie Oberflächendruck (Π), Oberflächenüberschusskonzentration (Γ), Fläche pro Molekül und Standard Gibbs-Energie der Adsorption (ΔGads) gewonnen. Aus Messungen der elektrischen Leitfähigkeit wurden die thermodynamischen Parameter ΔGm, ΔHm und ΔSm für die Mizellenbildung berechnet. Die Wechselwirkung zwischen dem Wirkstoff und Natriumdodecylsulfat in den Mischmizellen wurde mit Hilfe der elektrischen Leitfähigkeit und der optischen Spektroskopie im UV und sichtbaren Spektralbereich untersucht. Das spektroskopische Verfahren ermöglichte die Berechnung des Verteilungskoeffizienten (Kx) und der freien Energie der Verteilung. Die Leitfähigkeitsmessung war hilfreich für die Berechnung der thermodynamischen Parameter dieser Wechselwirkung. Weiterhin wurde der Einfluss verschiedener Aminosäuren auf die CMC von BAC untersucht.


*Correspondence address, Dr. Muhammad Usman, Assistant Professor, Department of Chemistry, GC University Faisalabad, Pakistan. Tel.: (+92)3 01-7 85 31 13, E-Mail:
**Dr. Khalid Mahmood, Department of Chemistry, Hazara University, Mansehra, KPK, Pakistan. Tel.: (+92)3 01-7 85 31 13, E-Mail:

Dr. Khalid Mahmood was born in January 1955. He studied for his M. Sc. at Gomal University, Dera Ismael Khan, KPK, Pakistan and joined same department as Lecturer in 1985. After obtaining his Ph. D. degree in 1997, he worked for Gomal University, Dera Ismael Khan till 2008 and then joined Hazara University, Mansehra, Pakistan as Professor in the Department of Chemistry. He retired from said post on January 16, 2015.

Muhammad Shakeel was born in August 1977. He did his Masters from University of Peshawar, Peshawar, Pakistan. He is PhD Scholar in Department of Chemistry, Hazara University, Mansehra, Pakistan. He is serving in Government Post Graduate College Abbottabad as Assistant Professor of Chemistry.

Dr. Mohammad Siddiq was born in February 1961. He did his masters from Gomal University, Dera Ismael Khan, Pakistan in 1985 and joined same Department as Lecturer in 1986. He obtained PhD degree from The Chinese University of Hong Kong in 2004. He joined Quad-i-Azam University, Islamabad as Associate Professor in 2004. At present, he is Professor and Chairperson of Department of Chemistry in same university.

Dr. Muhammad Usman was born in February 1979. He completed his Ph. D. in 2011 from Quaid-i-Azam University, Islamabad, Pakistan. He is, at present, working as Assistant Professor in Government College University, Faisalabad, Pakistan.


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Received: 2015-08-14
Accepted: 2015-10-15
Published Online: 2016-03-11
Published in Print: 2016-03-16

© 2016, Carl Hanser Publisher, Munich

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