Thermodynamic Solution Properties of Benzalkonium Chloride in Aqueous and Ethanolic Media and its Interactions with Organized Assemblies of Anionic Surfactant Sodium Dodecyl Sulphate and Amino Acids
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Khalid Mahmood
Khalid MahmoodDepartment of Chemistry, Hazara University, Mansehra, (KPK) PakistanSearch for this author in:Muhammad ShakeelDepartment of Chemistry, Hazara University, Mansehra, (KPK) Pakistan; Department of Chemistry, Govt. Postgraduate College Mandian, Abbottabad, (KPK) PakistanSearch for this author in:Mohammad SiddiqDepartment of Chemistry, Quaid-e-Azam University, Islamabad-45320, PakistanSearch for this author in:Muhammad UsmanDepartment of Chemistry, Government College University Faisalabad-38000, PakistanSearch for this author in:
Abstract
This manuscript reports the physicochemical behaviour of antimicrobial cationic surfactant benzalkonium chloride (BAC) as well as its interaction with the anionic surfactant sodium dodecyl sulfate in term of mixed micelle. Surface activity of pure BAC was studied by measuring the surface parameters i. e. surface pressure (Π), surface excess concentration (Γ), area per molecule and standard Gibbs free energy of adsorption (ΔGads). The electrical conductivity was measured to calculate the thermodynamic parameters like free energy of micellization, ΔGm, enthalpy of micellization, ΔHm and entropy of micellization, ΔSm. The interaction of the drug with sodium dodecyl sulfate was studied, in term of mixed micelle, by electrical conductivity and UV/Visible spectroscopy. Spectroscopic method helps to calculate the partition coefficient (Kx) and free energy of partition, while the conductivity method is helpful to calculate thermodynamic parameters of their interaction. The effect of different amino acids on CMC of BAC has also been studied.
Kurzfassung
In dieser Arbeit wird über die Eigenschaften des antimikrobiell wirksamen kationischen Tensids Benzalkoniumchlorid (BAC) berichtet sowie über dessen Wechselwirkung mit dem anionischen Tensid Natriumdodecylsulfat in den Mischmizellen. Aussagen über die Oberflächenaktivität von reinem BAC wurden aus Messungen der Oberflächenparameter wie Oberflächendruck (Π), Oberflächenüberschusskonzentration (Γ), Fläche pro Molekül und Standard Gibbs-Energie der Adsorption (ΔGads) gewonnen. Aus Messungen der elektrischen Leitfähigkeit wurden die thermodynamischen Parameter ΔGm, ΔHm und ΔSm für die Mizellenbildung berechnet. Die Wechselwirkung zwischen dem Wirkstoff und Natriumdodecylsulfat in den Mischmizellen wurde mit Hilfe der elektrischen Leitfähigkeit und der optischen Spektroskopie im UV und sichtbaren Spektralbereich untersucht. Das spektroskopische Verfahren ermöglichte die Berechnung des Verteilungskoeffizienten (Kx) und der freien Energie der Verteilung. Die Leitfähigkeitsmessung war hilfreich für die Berechnung der thermodynamischen Parameter dieser Wechselwirkung. Weiterhin wurde der Einfluss verschiedener Aminosäuren auf die CMC von BAC untersucht.
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© 2016, Carl Hanser Publisher, Munich
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- Interactions of Cellulase and Oleic Acid Solution Mixtures
- Effect of Surfactants on Hydrolysis of Mono-N-ethyl-o-toluidine Phosphate
- Thermodynamic Solution Properties of Benzalkonium Chloride in Aqueous and Ethanolic Media and its Interactions with Organized Assemblies of Anionic Surfactant Sodium Dodecyl Sulphate and Amino Acids
Articles in the same Issue
- Contents/Inhalt
- Contents
- Application
- Qualitative and Quantitative Analysis of Microbial Communities in Household Dishwashers in Germany
- Molecular Dynamics
- Mesoscopic Simulations on the Aggregate Behavior of Oligomeric Adamantane Surfactants in Aqueous Solutions
- Novel Surfactants
- Synthesis, Surface Activity and Application Properties of a Novel Ethoxylated Gemini Trisiloxane Surfactant
- Synthesis and Surface Active Properties of Novel Oligomer Betaine Surfactants
- Synthesis and Evaluation of Some Phenol-Based Anionic Gemini Amphiphiles: Studying Their Influence in the Preparation of Cu2O nanoparticles
- Scale Inhibition
- Preparation of a Multifunctional Terpolymer Inhibitor for CaCO3 and BaSO4 in Oil Fields
- Experimental and Theoretical Study on Corrosion Inhibition of Mild steel in 20 % Formic Acid Solution Using Schiff Base-Based Cationic Gemini Surfactant
- Physical Chemistry
- Dipeptide Glycyl-Glycine (Gly-Gly)–Ninhydrin Reaction: Effect of Alkanediyl-α,ω-bis(dimethylcetylammonium bromide) (16-s-16, s = 4, 5, 6) Gemini Surfactants on the Reaction Rate
- Interactions of Cellulase and Oleic Acid Solution Mixtures
- Effect of Surfactants on Hydrolysis of Mono-N-ethyl-o-toluidine Phosphate
- Thermodynamic Solution Properties of Benzalkonium Chloride in Aqueous and Ethanolic Media and its Interactions with Organized Assemblies of Anionic Surfactant Sodium Dodecyl Sulphate and Amino Acids