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Study of Mixed Micelles of Promethazine Hydrochloride (PMT) and Nonionic Surfactant (TX-100) Mixtures at Different Temperatures and Compositions

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Published/Copyright: May 13, 2015
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Tenside Surfactants Detergents
From the journal Tenside Surfactants Detergents Volume 52 Issue 3

Abstract

Herein, we have investigated the interaction between a phenothiazine drug promethazine hydrochloride (PMT) and nonionic surfactant t-octylphenoxypolyethoxyethanol (TX-100) in aqueous solutions using a conductometric technique at different temperatures and compositions. The evaluated critical micelle concentration (cmc) values are lower than cmcid values suggesting attractive interactions of mixed micelles components. It is observed that with the increase in temperature, the cmc value increases first and after the value decreases at higher temperature. At 298.15 K, the maximum cmc values were attained in presence or absence of TX-100. The bulk properties of solution were studied by means of different theoretical models reported in the literature such as Clint, Rubingh, Motomura, and Rodenas for explanation and comparison of results of different binary mixtures of the drug and TX-100. The negative values of interaction parameter (β) obtained from the regular solution theory (RST) recommend synergistic interactions. Activity coefficients (f1 and f2) calculated by all theoretical models used herein were obtained to be always below unity indicating nonideality in all binary mixtures. Thermodynamic parameters (like standard Gibbs energy (ΔG°m), enthalpy (ΔH°m), and entropy (ΔS°m)) are also evaluated which propose dehydration of hydrophobic portion of the drug at higher temperatures. The above results obtained may be helpful in model drug delivery systems.

Kurzfassung

Wir untersuchten die Wechselwirkungen zwischen dem Phenothiazinwirkstoff Promethazinhydrochlorid (PMT) und dem nicht-ionischen Tensid t-Octylphenoxypolyethoxyethanol (TX-100) in wässrigen Lösungen mittels Konduktometrie bei verschiedenen Temperaturen und Zusammensetzungen. Die bestimmten kritischen Mizellenbildungkonzentrationen (cmc) sind alle niedriger als die idealen cmc-Werte, was auf anziehende Wechselwirkungen der Komponenten in den Mischmizellen hindeutet. Es wurde festgestellt, dass mit zunehmender Temperatur die kritischen Mizellenbildungkonzentrationen zunächst auch ansteigen, dann aber bei höheren Temperaturen wieder abnahmen. Bei 298,15 K wurde sowohl in An- als auch in Abwesenheit von TX-100 eine maximale cmc erhalten. Die Bulkeigenschaften der Lösungen wurden mittels verschiedener theoretischer Modelle wie den von Clint, von Rubingh, von Motomura, und von Rodenas untersucht, um die Ergebnisse für die verschiedenen binären Mischungen aus dem Wirkstoff und TX-100 zu vergleichen und zu erklären. Die negativen Wechselwirkungeparameter (β), die mit der Regulären Lösungstheorie (RST) bestimmt wurden, weisen auf synergistische Wechselwirkungen hin. Die Aktivitätskoeffizienten (f1 and f2), die mit allen o. g. theoretischen Modellen berechnet wurden, waren immer kleiner als eins, was nicht-ideales Verhalten bei allen binären Mischungen anzeigt. Die thermodynamischen Parameter (Standard-Gibbs-Energie (ΔG°m), Enthalpie (ΔH°m), und Entropie (ΔS°m)) wurden ebenfalls berechnet. Die Ergebnisse deuten auf eine Dehydration des hydrophoben Anteils des PTM bei höheren Temperaturen hin. Die obigen Ergebnisse können für Modellsysteme der Wirkstoffzuführung nützlich sein.

Key words: Phenothiazine drug; Promethazine hydrochloride (PMT); Critical micelle concentration; Conductivity; Interaction parameter
Stichwörter: Phenothiazinwirkstoff; Promethazinhydrochlorid (PMT); kritische Mizellenbildungskonzentration; Leitfähigkeit; Wechselwirkungsparameter
* Correspondence address, Dr. Malik Abdul Rub, Chemistry Department, King Abdulaziz University, Jeddah-21589, Saudi Arabia, or, Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah-21589, Saudi Arabia, E-Mail: ,

Dr. Malik Abdul Rub received his M.Sc. and Ph.D. degrees from the Aligarh Muslim University. Now he has joined King Abdulaziz University as a Assitant Professor in the Chemistry Department. His current research interests are mixed micellization study of amphiphilic drugs with different additives and clouding phenomenon in amphiphilic systems.

Dr. Farah Khan is currently a Post Doc Fellow in Department of Chemistry, Aligarh Muslim University, Aligarh. She received his Ph.D. degree from Aligarh Muslim University. Her research interest is physicochemical behaviour of micellar solutions (gemini as well as conventional).

Dr. Dileep Kumar received his M.Sc. and Ph.D. degrees from Aligarh Muslim University, (AMU) Aligarh. Currently He is Post Doc Fellow in Faculty of Science, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia. His current research interests are chemical kinetics, catalysis and surfactant systems.

Prof. Abdullah M. Asiri is a Professor of King Abdulaziz University of Chemistry Department. He received his Ph.D. degree from University of Walls College of Cardiff, U.K. He has authored more than 400 research papers. He is director of Centre of excellence of Advanced Materials and Research. His current research interests are smart molecules and materials, novel photochromic and thermochromic systems, organic synthesis of heterocyclic compounds, synthesis of polymers functionalized with organic dyes and nano hybrid materials.

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Received: 2014-11-21
Accepted: 2015-02-23
Published Online: 2015-05-13
Published in Print: 2015-05-15

© 2015, Carl Hanser Publisher, Munich

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https://doi.org/10.3139/113.110371
Keywords for this article
Phenothiazine drug; Promethazine hydrochloride (PMT); Critical micelle concentration; Conductivity; Interaction parameter

Articles in the same Issue

  1. Contents/Inhalt
  2. Contents
  3. Review Article
  4. Polyphenolics-Phospholipid Complexes as Natural Cosmetic Ingredients: Properties and Application
  5. Cleaning and Hygiene
  6. Construction of a Virtual Washing Machine
  7. Larger Washing Machines and Smaller Household Size – How Can They Fit Together? Simulation of a Sustainable Use of Washing Machines
  8. Development of a Method for the Analysis of Microbial Load Reduction Factors on Dishes Cleaned by Hand and by Machine
  9. Environmental Chemistry
  10. A new Iodobismuthate Method with a Low Volume Filtration Device as a New Tool for the Determination of Microgram Oxyethylate Amounts
  11. Synthesis
  12. Hybrid Biosurfactant: Syntheses of Hybrid Corynomycolic Acid and its Monolayer Formation
  13. Efficient Synthesis of Nanostructured Poly(aniline-co-m-aminobenzoic acid) Copolymer in Presence of DBSA Surfactant
  14. Physical Chemistry
  15. Study of Mixed Micelles of Promethazine Hydrochloride (PMT) and Nonionic Surfactant (TX-100) Mixtures at Different Temperatures and Compositions
  16. Application
  17. Study of Underwater Contact Angles for Formulation of Fatliquoring Emulsions Using Green Surfactants
  18. Interfacial Properties of Alkylbenzene Sulfonates Ternary Mixtures
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