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Validation of an HPLC Method for Determining log Pow Values of Surfactants

  • Charles Eadsforth , Carole Adams , Tom Austin , Tom Corry , Stuart Forbes and Sarah Harris
Published/Copyright: May 1, 2013
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Tenside Surfactants Detergents
From the journal Tenside Surfactants Detergents Volume 51 Issue 3

Abstract

The aim of this study was to test whether the HPLC method for determining the n-octanol/water partition coefficient (log Pow) data of chemicals could be applied to alcohol ethoxylates (non-ionic surfactants). In order to carry out this evaluation, the range of the standard calibration line first had to be extended from 0 – 6 (OECD 117) to 0 – 9. Experimental studies confirmed that the components of alcohol ethoxylates were eluted from the HPLC column in order of their predicted hydrophobicity. The HPLC method has proved to be particularly advantageous for the determination of log Pow values for alcohol ethoxylate products as it can generate data for highly hydrophobic material (log Pow > 6) and has sufficient resolving power to separate individual alcohol components from their ethoxylated moieties. This adapted HPLC method could be used to generate data for REACH submissions.

Kurzfassung

Ziel dieser Untersuchung war zu testen, ob man eine HPLC-Methode zur Bestimmung des n-Octanol/Wasser Verteilungskoeffizienten (log Pow) für Chemikalien auf Alkoholethoxilate (nichtionische Tenside) anwenden kann. Um diese Beurteilung ausführen zu können, musste zuerst der Bereich der Standard-Kalibrierung von 0 – 6 (OECD 117) auf 0 – 9 erweitert werden. Die experimentellen Studien bestätigen, dass die Alkoholethoxilate entsprechend ihrer vorgesagten Hydrophobizität aus der HPLC-Säule gespült wurden. Die HPLC-Methode erwies sich als besonders vorteilhaft für die Bestimmung von log Pow-Werten der Alkoholethoxilate, weil sie Daten von sehr hydrophoben Materialien (log Pow > 6) generiert und zudem eine genügend hohe Auflösung zur Abtrennung der individuellen Alkoholverbindungen von ihren ethoxilierten Resten besitzt. Diese adaptierte HPLC-Methode kann eingesetzt werden, um die Verteilungskoeffizienten für eine REACH-Einreichung zu bestimmen.

Key words: Alcohol ethoxylates; surfactants; HPLC method (OECD 117); partition coefficient (n-octanol/water); QSAR predictions
Stichwörter: Alkoholethoxilate; Tenside; HPLC-Methode (OECD 117); Verteilungskoeffizient (n-Octanol/Wasser); QSAR-Vorhersagen
* Correspondence address Dr. Charles Eadsforth, Shell Health, Brabazon House, Threapwood Road, Concord Business Park, Manchester, M22 9PS, United Kingdom, Tel.: +4 40 19 09 53 24 69, E-Mail:

Charles Eadsforth holds a B. Sc. (Hons.) in Applied Chemistry and a Ph. D. in Biochemistry from the University of Salford, Manchester. He has worked for Shell since 1980, initially in research at Sittingbourne Research Centre and Shell Technology, Thornton and more recently providing environmental support to Shell businesses. He is a member of a number of international working groups dealing with environmental safety assessment of chemicals and oil products.

Carole Adams has thirty three years experience in Analytical chemistry working for Shell UK. Experienced in a wide range of analytical techniques including Gas chromatography, liquid chromatography, size exclusion chromatography, mass spectrometry, IR, titrimetry, polarography as well as wet chemistry techniques.

Tom Austin holds a B. Sc. (Hons.) in Biology from the University of Manchester. He worked for two years as an environmental scientist/ecologist before joining Shell as an ecotoxicologist.

Tom Corry is an under-graduate student from the University of Manchester where he is currently studying for a bachelor's degree in Chemistry. Tom worked at Shell during an industrial placement opportunity whilst undertaking his degree.

Stuart Forbes is currently Team Leader of the Separations, Spectroscopy and Thermal Analysis Group of Shell Global Solutions (Thornton, UK) having previously worked in the Shell Research Laboratories at Sittingbourne and Amsterdam. Following his studies for first and post-graduate degrees at Nottingham and Aberdeen respectively, Stuart joined Shell where he has been involved in a variety of product, process and environmental projects spanning the energy and petrochemical sectors. In recent years he has been heavily involved in analytical consultancy work for REACH and environmental/human health risk assessments on petroleum products. Stuart has made conference presentations and published papers on a variety of subjects throughout his career, and taken an active role at national and international level in many work-related organisations including CONCAWE, Energy Institute, Royal Society of Chemistry and UKAS.

Sarah Harris graduated from John Moore's University in 2012 with a B. Sc. (Hons.) in Biochemistry. During this time she also gained a year's industrial experience within a toxicology laboratory. Sarah joined Shell as a graduate laboratory assistant and has worked on the enhanced experimentation programme for Shell Health for 16 months.

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Received: 2013-10-30
Revised: 2014-02-12
Published Online: 2013-05-01
Published in Print: 2014-05-15

© 2014, Carl Hanser Publisher, Munich

Articles in the same Issue

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Review Article
  6. Arginine Based Novel Cationic Surfactants: A Review
  7. Application
  8. Selection of Surfactants on the Basis of Foam and Emulsion Properties to Obtain the Fire Fighting Foam and the Degreasing Agent
  9. Negative Synergistic Effect on Foaming in Body Care Products with Silicone Oil and the Needle-Like Crystal of Ethylene Glycol Distearate
  10. Technical Chemistry
  11. Wetting Ability in Aqueous Mixtures of Amine Oxide with Anionic and Nonionic Surfactants
  12. Environmental Chemistry
  13. Validation of an HPLC Method for Determining log Pow Values of Surfactants
  14. Removal of Lead From Aqueous Media Using Carbonized and Acid Treated Orange Peel
  15. Corrosion and Scale Inhibition Properties by Phosphate-free and Nitrogen-free Scale Inhibitor in Cooling Water System
  16. Preparation and Application of Fluorescent-tagged Inhibitor for Calcium Phosphate and Iron(III) Hydroxide Scales in Industrial Cooling Water Systems
  17. Novel Surfactants
  18. Effect of Tuned Head Polarity of Cetyl Trimethyl Ammonium Bromide on their Physicochemical Properties
  19. Physical Chemistry
  20. Aggregation Behavior of PEO-PPO-PEO Tri-Block Copolymer (Pluronic®L64) in Nonionic Surfactant Additives Environment
  21. Surfactant Processing
  22. Solidification of Surfactants and Detergents to Dust-Free Free Flowing Pastilles
https://doi.org/10.3139/113.110303
Keywords for this article
Alcohol ethoxylates; surfactants; HPLC method (OECD 117); partition coefficient (n-octanol/water); QSAR predictions

Articles in the same Issue

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Review Article
  6. Arginine Based Novel Cationic Surfactants: A Review
  7. Application
  8. Selection of Surfactants on the Basis of Foam and Emulsion Properties to Obtain the Fire Fighting Foam and the Degreasing Agent
  9. Negative Synergistic Effect on Foaming in Body Care Products with Silicone Oil and the Needle-Like Crystal of Ethylene Glycol Distearate
  10. Technical Chemistry
  11. Wetting Ability in Aqueous Mixtures of Amine Oxide with Anionic and Nonionic Surfactants
  12. Environmental Chemistry
  13. Validation of an HPLC Method for Determining log Pow Values of Surfactants
  14. Removal of Lead From Aqueous Media Using Carbonized and Acid Treated Orange Peel
  15. Corrosion and Scale Inhibition Properties by Phosphate-free and Nitrogen-free Scale Inhibitor in Cooling Water System
  16. Preparation and Application of Fluorescent-tagged Inhibitor for Calcium Phosphate and Iron(III) Hydroxide Scales in Industrial Cooling Water Systems
  17. Novel Surfactants
  18. Effect of Tuned Head Polarity of Cetyl Trimethyl Ammonium Bromide on their Physicochemical Properties
  19. Physical Chemistry
  20. Aggregation Behavior of PEO-PPO-PEO Tri-Block Copolymer (Pluronic®L64) in Nonionic Surfactant Additives Environment
  21. Surfactant Processing
  22. Solidification of Surfactants and Detergents to Dust-Free Free Flowing Pastilles
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