Phase Separation Study of a Surface-Active Drug, Promazine Hydrochloride, in Presence of Surfactants and Ureas
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Kabir-ud-Din
Abstract
As clouding in drugs causes high concentration of drug at a particular site which may prove harmful to the body, the clouding behaviour of a tricyclic phenothiazine drug promazine hydrochloride (PMZ) in aqueous solutions has been studied in the presence of surfactants and ureas. The cloud point (CP) decreases with increase in pH due to deprotonation of the drug molecules. Addition of non-ionic and cationic (conventional as well as Gemini) surfactants increased the CP whereas anionic surfactants showed a peaked profile. The urea family additives influenced the CP in both ways that depended whether they contain >C=O or >C=S moiety: the former interacts with the micelles and lowers the CP while the latter (due to its electropositive character) may not interact and hence CP increases. Dye solubilization results indicate micellar growth with the addition of surfactants in PMZ solutions. The results are interpreted taking cognizance of mixed micelle formation, hydrophobic interactions, and/or change in solvent structure.
Kurzfassung
Da die Trübung von Medikamenten hohe Arzneimittelkonzentrationen in besonderer Weise bewirken, die sich für den menschlichen Körper als gesundheitsschädlich erweisen können, wurde das Trübungsverhalten eines trizyklischen Phenothiazin-Medikaments, Promazinhydrochlorid (PMZ), in wässriger Lösung in Gegenwart von Tensiden und Harnstoffen untersucht. Der Trübungspunkt (CP) nimmt bei pH-Erhöhung aufgrund der Deprotonierung der Arzneimoleküle ab. Die Zugabe von nichtionischen und kationischen (konventionelle sowie Gemini-Tenside) Tensiden erhöht den Trübungspunkt, während anionische Tenside zunächst eine Erhöhung und dann eine Abnahme zeigen. Die Harnstoffadditive beeinflussen den Trübungspunkt in beide Richtungen, abhängig davon, ob diese eine >C=O oder eine >C=S Gruppe enthalten: Die erstere interagiert mit den Mizellen und erniedrigt den Trübungspunkt, während die letztere (aufgrund ihres elektropositiven Charakters) nicht interagiert und infolgedessen den Trübungspunkt erhöht. Farbstofflösungen indizieren ein mizellares Wachstum bei Zugabe von Tensiden in PMZ-Lösungen. Die Ergebnisse werden unter Kenntnisnahme von Mischmizellenformationen, hydrophoben Wechselwirkungen und/oder Wechsel in der Lösemittelstruktur interpretiert.
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© 2008, Carl Hanser Publisher, Munich
Artikel in diesem Heft
- Contents/Inhalt
- Contents
- Abstracts
- Abstracts
- Detergent Ingredient
- Quantitative Determination of Tetraacetylethylenediamine in Laundry Powder by FTIR Spectrometry Using Partial Least Squares Algorithm
- Physical Chemistry
- Conductivity Measurements as a Method for Studying Ionic Technical Grade Surfactants
- Electrocatalytic Hydrogenation and Hydrogenolysis of Aromatic Halides by Raney Nickel in the Presence of Different Surfactants
- Phase Separation Study of a Surface-Active Drug, Promazine Hydrochloride, in Presence of Surfactants and Ureas
- Surface Activity of Newly Nonionic Surfactants at Air/Water Interface and their Interaction with Clay and Teflon
- Review Article
- 50 Years of Environmental Monitoring at Henkel
Artikel in diesem Heft
- Contents/Inhalt
- Contents
- Abstracts
- Abstracts
- Detergent Ingredient
- Quantitative Determination of Tetraacetylethylenediamine in Laundry Powder by FTIR Spectrometry Using Partial Least Squares Algorithm
- Physical Chemistry
- Conductivity Measurements as a Method for Studying Ionic Technical Grade Surfactants
- Electrocatalytic Hydrogenation and Hydrogenolysis of Aromatic Halides by Raney Nickel in the Presence of Different Surfactants
- Phase Separation Study of a Surface-Active Drug, Promazine Hydrochloride, in Presence of Surfactants and Ureas
- Surface Activity of Newly Nonionic Surfactants at Air/Water Interface and their Interaction with Clay and Teflon
- Review Article
- 50 Years of Environmental Monitoring at Henkel
