Chapters in this book

1. Frontmatter I
2. PREFACE V
3. CONTENTS VII
4. CONTRIBUTORS X
5. PANEL A . KERNICTERUS OF PREMATURITY: INCIDENCE AND AETIOLOGICAL FACTORS
6. Introduction 3
7. The Incidence of Kernicterus not due to Haemolytic Disease among Premature Babies 4
8. Peak Levels of Serum Bilirubin in Normal Premature Infants 10
9. Experience with Kernicterus in Premature Infants 13
10. The Neurological Sequelae of Hyperbiliruhinaemia of Prematurity 20
11. Physiological Jaundice Re-examined 29
12. PANEL B. FACTORS INFLUENCING THE LIFE SPAN OF THE RED BLOOD CELL
13. Introduction 39
14. Physiological Mechanisms of Red Blood Cell Destruction 41
15. The Life Span of Erythrocytes in the Newborn 47
16. The Relationship between Abnormality of Glutathione Metabolism in Erythrocytes from Newborn Infants and the Occurrence of Drug-induced Haemolytic Anaemia 52
17. Peculiarities of Erythrocytes of the Newborn 54
18. Metabolism of Glutathione by Erythrocytes from Normal Newborn Infants 63
19. A Possible Effect of Vitamin K₃ on Erythrocyte Metabolism 68
20. The Destruction of Red Cells by Antibodies 73
21. The Oxygen-Carrying Capacity and Glycolytic Rates of Erythrocytes from Newborn Infants with Erythroblastosis Caused by Rh Incompatibility 79
22. PANEL C. THE METABOLISM AND EXCRETION OF BILIRUBIN
23. Introduction 85
24. The Mechanism of Glucuronide Formation 88
25. Studies of Glucuronide Formation 94
26. Bilirubin Sulfate 97
27. The Effect of Sodium Glucuronate and Glucuronolactone on Bilirubin Conjugation 99
28. Factors Influencing the Synthesis of Direct Reacting Bilirubin 102
29. Familial Defect of Glucuronidation: in vivo Studies 105
30. Conjugated Hyperbilirubinaemia : A Transport 108
31. Bilirubin Metabolism in the Foetus 112
32. Glucuronide Formation in Pre-Natal and Neonatal Life 115
33. Foetal and Neonatal Development of the Glucuronide-Conjugating System 121
34. Conclusion 128
35. PANEL D. THE PATHOLOGY OF KERNICTERUS AND THE CYTOTOXICITY OF BILIRUBIN
36. Introduction 135
37. Pathology of Human Kernicterus 140
38. Kernicterus in Gunn's Strain of Rats 150
39. The in vivo Crystallization of Bilirubin in Hyperbilirubinaemic Infants 153
40. Experimental Studies on the Toxicity of Bilirubin 161
41. Toxicity of Haeme Pigments in Different Test Systems 167
42. Bilirubin Encephalopathy-Cytotoxicity 170
43. The Mode of Action of Bilirubin on Mitochondria 174
44. PANEL E. FACTORS INFLUENCING THE DISTRIBUTION OF BILIBUBIN IN THE BODY
45. Introduction 195
46. The Effects on Premature Infants of Sulfisoxazole in the Neonatal Period 196
47. Factors Influencing the Binding of Bilirubin by Albumin 199
48. The Effect of Certain Substances on Bilirubin Levels and Occurrence of Kernicterus in Genetically Jaundiced Rats 208
49. The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies 219