Chapters in this book

1. Frontmatter i
2. Publisher's Note vi
3. Foreword vii
4. Preface xi
5. Contents xiii
6. Introduction xvii
7. 1. A Canadian Trail of Medical Research 1
8. Part I: Insulin And Glucagon
9. 2. The internal secretion of the pancreas (selected pages of the original manuscript). F. G. Banting and C. H. Best. 1921 23
10. 3. The internal secretion of the pancreas. F. G. Banting and C. H. Best. Trans. Acad. Med. Toronto, 1920-22 37
11. 4. The Internal Secretion of the Pancreas 42
12. 5. Pancreatic Extracts 61
13. 6. Preliminary Studies on the Physiological Effects of Insulin 73
14. 7. Pancreatic Extracts in the Treatment of Diabetes Mellitus: Preliminary Report 89
15. 8. The Effects of Insulin on Experimental Hyperglycaemia in Rabbits 101
16. 9. The Preparation of Insulin 116
17. 10. The Effect of Insulin on the Dextrose Consumption of Perfused Skeletal Muscle 133
18. 11. The Fate of the Sugar Disappearing under the Action of Insulin 140
19. 12. Oxidation and Storage of Glucose under the Action of Insulin 155
20. 13. Insulin in Tissues other than the Pancreas 169
21. 14. Diet and the Insulin Content of Pancreas 179
22. 15. Insulin Extractable from the Pancreas and Islet Cell Histology 192
23. 16. Extractable Insulin of the Pancreas and Effectiveness of Oral Hypoglycaemic Sulphonylureas in the Treatment of Diabetes in Man—A Comparison 204
24. 17. A Study of the Prevalence of Diabetes in an Ontario Community 212
25. 18. The Prevention of Diabetes 229
26. 19. The Protein Anabolic Effect of Testosterone Propionate and its Relationship to Insulin 244
27. 2O. The Pathologic Effects of Large Amounts of Glucagon 251
28. 21. Glucagon and Metaglucagon Diabetes in Rabbits 260
29. 22. Effect of Insulin and Glucagon on Tumour Growth 269
30. 23. Effect of Prolonged Administration of Tolbutamide in Depancreatized Dogs 275
31. 24. A Clinical Assessment of Foetal Calf Insulin 286
32. 25. The Late John James Rickard Macleod 292
33. 26. Frederick Grant Banting, 1891-1941 294
34. 27. Reminiscences of the Researches Which Led to the Discovery of Insulin 302
35. 28. The Banting Memorial Lecture: Insulin and diabetes in retrospect and in prospect. 1945 311
36. 29. The Banting Memorial Lecture: Insulin. 1952 324
37. 30. Diabetes since 1920 340
38. 31. Insulin and Glucagon: A Review 350
39. 32. The Future in the Field of Diabetes 360
40. Part II: Choline and Lipotropic Phenomena
41. 33. A Brief History of the Discovery of the Lipotropic Factors 367
42. 34. The Effect of Lecithine on Fat Deposition in the Liver of the Normal Rat 375
43. 35. The Effects of the Components of Lecithine upon Deposition of Fat in the Liver 385
44. 36. Choline and the Dietary Production of Fatty Livers 392
45. 37. The Distribution of Choline 404
46. 38. The Effects of Cholesterol and Choline on Liver Fat 412
47. 39. The Effect of Anterior Pituitary Extracts on the Liver Fat of Various Animals 419
48. 40. A Study of the Source of Liver Fat Using Deuterium as an Indicator 437
49. 41. The Lipotropic Action of Methionine 452
50. 42. The Mode of Action of Lipotropic Agents: Proof of the in Vivo Incorporation of Triethyl-β-hydroxyethyl- ammonium Hydroxide into the Phospholipid Molecule 458
51. 43. Hypertension of Renal Origin in Rats Following less than One Week of Choline Deficiency in Early Life 474
52. 44. Liver Damage Produced by Feeding Alcohol or Sugar and its Prevention by Choline 480
53. 45. Effects of Dietary Protein, Lipotropic Factors, and Re-alimentation on Total Hepatic Lipids and Their Distribution 494
54. 46. Lipotropic Dose-Response Studies in Rats: Comparisons of Choline, Betaine and Methionine 510
55. 47. Kwashiorkor Type of Fatty Liver in Primates 518
56. 48. The Croonian Lecture: The lipotropic agents in the protection of the liver, kidney, heart and other organs of experimental animals 527
57. Part III: Other Physiological Studies
58. 49. Observations on Olympic Athletes 547
59. 50. The Nature Of The Vaso-Dilator Constituents Of Certain Tissue Extracts 557
60. 51. The Disappearance of Histamine from Autolysing Lung Tissue 578
61. 52. The Inactivation of Histamine 586
62. 53. Preparation of Heparin and its Use in the First Clinical Cases 613
63. 54. Heparin and the Thrombosis of Veins Following Injury 624
64. 55. Heparin and the Formation of White Thrombi 645
65. 56. Heparin and Coronary Thrombosis in Experimental Animals 655
66. 57. Experimental Exchange Transfusion Using Purified Heparin 661
67. 58. The Canadian Project for the Preparation of Dried Human Serum for Military Use 670
68. Part IV: General Papers
69. 59. The Division of Naval Medical Research, Royal Canadian Navy 679
70. 60. The Organization of Physiology 684
71. 61. Convocation Address, University of Maine, August 12,1955 690
72. Part V: Epilogue 697
73. Bibliography 701