Topochemical models for anti-HIV activity of 1-alkoxy-5-alkyl-6-(arylthio)uracils
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S. Bajaj
und
A. Madan
Abstract
Relationship between topochemical indices and anti-HIV-1 (HTLV-III) inhibitory activity of 1-alkoxy-5-alkyl-6-(arylthio)uracils has been studied. Superadjacency, an adjacency-cum-distance-based, topochemical index and Wiener’s, a distance-based, topochemical index were calculated for a set of 36 1-alkoxy-5-alkyl-6-(arylthio)uracils. Resulting data were analyzed and suitable models were developed after identification of the active ranges. Subsequently, a biological activity was assigned to each of the compounds using these models and compared with the reported anti-HIV-1 activity. High accuracy of prediction was observed using these models. Statistical analysis revealed significance of the proposed models as well as a lack of correlation between the topochemical indices employed for the chosen data set.
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© 2007 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
- Spectrophotometric determination of microamounts of quercetin based on its complexation with copper(II)
- Oxygen evolution on Ti/Co3O4-coated electrodes in alkaline solution
- The zeta potential of kaolin suspensions measured by electrophoresis and electroacoustics
- Fluidization behavior of oil-contaminated sand
- Software sensors for monitoring of a solid waste composting process
- Calcined Ni—Al layered double hydroxide as a catalyst for total oxidation of volatile organic compounds: Effect of precursor crystallinity
- Thermodynamic possibilities and constraints of pure hydrogen production by a chromium, nickel, and manganese-based chemical looping process at lower temperatures
- Death kinetics of Escherichia coli in goat milk and Bacillus licheniformis in cloudberry jam treated by ohmic heating
- Topochemical models for anti-HIV activity of 1-alkoxy-5-alkyl-6-(arylthio)uracils
- Acidity, lipophilicity, solubility, absorption, and polar surface area of some ACE inhibitors
- Silver as anode in cryolite—alumina-based melts
- Multicomponent facile synthesis of novel dihydroazolopyrimidinyl carbamides
- Z. Platková, M. Polakovič, V. Štefuca, M. Vandáková, and M. Antošová: Selection of Carrier for Immobilization of Fructosyltransferase from Aureobasidium pullulans
