Synthesis and cyclization reactions with pyrazolopyrimidinyl keto esters part I. Reactivity of pyrazolopyrimidinyl β-keto ester and pyrazolopyrimidinyl α,β-unsaturated ketones
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M. Awas
Abstract
5-Acetyl-4,5-dihydro-1-phenylpyrazolo[3,4-d]pyrimidin-4-one was prepared and subjected to various chemical transformations to give novel 5-heterocyclic pyrazolopyrimidinone derivatives of expected important biological activity. Then, the latter compounds were used to obtain β-keto ester and α,β-unsaturated carbonylpyrazolopyrimidinones which were used as alternate precursors to produce new pyrazolopyrimidinones substituted with five-membered heterocycles such as pyrazole and isoxazole. The structure of these compounds was identified on the basis of their chemical behaviour as well as elemental and spectral analysis.
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© 2006 Institute of Chemistry, Slovak Academy of Sciences
Articles in the same Issue
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- Synthesis and cyclization reactions with pyrazolopyrimidinyl keto esters part I. Reactivity of pyrazolopyrimidinyl β-keto ester and pyrazolopyrimidinyl α,β-unsaturated ketones
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Articles in the same Issue
- FTIR study of gamma-irradiated cis-1,4-polyisoprene
- Comparison of betaine and l-stachydrine as phase-transfer catalysts in Michael addition and Darzens reaction
- Synthesis and cyclization reactions with pyrazolopyrimidinyl keto esters part I. Reactivity of pyrazolopyrimidinyl β-keto ester and pyrazolopyrimidinyl α,β-unsaturated ketones
- Electrodeposition of mercury film on electrodes modified with clay minerals
- Properties of Ni-W alloy coatings on steel substrate
- Effect of chloride ions on the kinetics of nitrobenzene reduction by powdered iron
- Displacement washing of pulp with urea solutions
- Methane esterification in oleum
- Momentum transfer in an agitated vessel with off-centred impellers
- Optimal control of a two-stage reactor system
- Effect of span 20 concentration on oxalic acid production from post-refining fatty acids by Aspergillus niger XP
- Citric acid production from raw glycerol by acetate mutants of Yarrowia lipolytica
- Phosphonium ionic liquids as new, reactive extractants of lactic acid
