Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
Hypolipidemic Activity Evaluation of DRF/AY/4013, an Herbal Formulation in Experimentally Induced Hyperlipidemic Rats
-
Sagarika Shankar Gajbhiye
Veröffentlicht/Copyright:
11. Juli 2008
The present study was designed to evaluate the efficacy of an herbal product DRF/AY/4013 for its hypolipidemic activity in various experimental rat models. An indigenous polyherbal formulation DRF/AY/4013, composed of different phytoconstituents like Terminalia arjuna, Commiphora mukul, Allium sativum, Cyperus rotundus and Acorus calamus extracts, exhibited potential hypolipidemic activity treatment in triton induced hyperlipidemic rats. Further, it also showed promising hypolipidemic activity in both high fat diet (HFD) induced hyperlipidemic rats and propylthiouracil (PTU) induced hyperlipidemic rats. In all the experimental hyperlipidemic models, DRF/AY/4013 treatment demonstrated dose dependent hypolipidemic activity at 200, 400 and 800 mg/kg dose levels by decreasing serum lipid and lipoprotein profile, atherogenic index (AI) and lipid peroxidation process. Furthermore the 800 mg/kg dose level group V rats exhibited pronounced hypolipidemic activity almost comparable to atorvastatin standard drug (10 mg/kg) treated group VI rats. In HFD induced hyperlipidemic rat model, DRF/AY/4013 treated groups III, IV, V exhibited mild, minimal and negligible degree of cytoplasmic fatty infiltration respectively in hepatocytes as compared to marked degree in untreated control HFD induced group II rats. In short, the DRF/AY/4013 treatment demonstrated a promising hypolipidemic activity in all experimental rat models and therefore, needs further clinical evaluation in humans.
Keywords: herbal product; hypolipidemic activity; Hyperlipidemia; experimental rat models; rats; cardiovascular diseases; cardiovascular risks
Published Online: 2008-7-11
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- Review Article
- Potential Health Benefits of Garlic (Allium Sativum): A Narrative Review
- Effect of Pranayama [Voluntary Regulated Yoga Breathing] and Yogasana [Yoga Postures] in Diabetes Mellitus (DM): A Scientific Review
- Research Advances on the Anti-aging Profile of Fructus lycii: an Ancient Chinese Herbal Medicine
- Complementary and Alternative Medicine Use in Juvenile Idiopathic Arthritis: A Systematic Review of Prevalence and Evidence
- Research Article
- Effects of Harungana madagascariensis Stem Bark Extract on the Antioxidant Markers in Alloxan Induced Diabetic and Carrageenan Induced Inflammatory Disorders in Rats
- Effect of Some Ayurvedic Vajikaran Rasayana Herbs on Heat Induced Testicular Damage in Male Albino Rats
- An Extract from North American Ginseng Stimulates Spontaneous Immunity in Infant Mice: Sustained, Augmented Immunity in Adulthood Long after Withdrawal of the Extract
- Cardiovascular and Anti-Platelet Aggregation Activities of Extracts from Solanum torvum (Solanaceae) Fruits in Rat
- Evaluation of Antioxidant and Free Radical Scavenging Activities of Oxystelma esculentum in Various In Vitro Models
- The Antioxidant Defense System Induced by Methanol Extract of Careya arborea in N-Nitroso-diethylamine (NDEA) Induced Hepatocarcinogenesis
- Inhibition of Carbohydrate Digestive Enzymes by Talinum portulacifolium (Forssk) Leaf Extract
- Magnetotherapy: Changes in the Nature of Biomolecules under a Constant Magnetic Field
- Inhalation of Neroli Essential Oil and Its Anxiolytic Effects
- Protective Role of Grewia asiatica on Blood after Radiation Exposure in Mice
- Lepidium meyenii (Maca) Varieties Did Not Alter Female Reproductive Parameters in Adult Intact Rats
- Hypolipidemic Activity Evaluation of DRF/AY/4013, an Herbal Formulation in Experimentally Induced Hyperlipidemic Rats
- Slimpid May Boost Plasma IGF-1 Level and Improve the Quality of Life in Patients with Risk of Developing Metabolic Syndrome
- Effect of Argan Oil on Platelet Aggregation and Bleeding Time: A Beneficial Nutritional Property
- Comparative Analysis of CAM Use in the U.S. Cancer and Noncancer Populations
- Antiangiogenic Effects of Chinese Medicines (Hachimijiogan and Kogikujiogan) on Vascular Endothelial Growth Factor-A-Induced Tube Formation in Human Umbilical Vein Endothelial Cells Co-Cultured with Fibroblasts
- Evaluation of the Antioxidant Activity and Lipid Peroxidation of the Leaves of Vernonia amygdalina
- Heart Rate Dynamics during Shambhavi Mahamudra- A Practice of Isha Yoga
- The Effects of Borage Oil Supplementation on Non-Steroidal Anti-Inflammatory Drug Requirements in Patients with Rheumatoid Arthritis
- Australian Natural Therapists and Mental Health: Survey of Treatment Approaches and Referral Patterns
- Tinospora cordifolia Protects Mouse Peritoneal Macrophages From LPS-induced Death
- Antioxidant and Acetylcholinesterase Inhibitory Properties of the Indian Medicinal Plant "Shankhapushpi" Used for Enhancing Memory Function
- Effect of Concomitant Administration of Aqueous Extract of Pleurotus pulmonarius and Metformin in Diabetic Mice
- Anti-Adipogenic Activity of Capsicum annum (Solanaceae) in 3T3 L1
- Hypoglycemic Activity of Aqueous Extract of Oscillatoria limnetica, Blennothrix ganeshii, Hydrodictyon reticulatum and Microcoleous lacustris in Normal and Alloxan Induced Diabetic Mice
- Systematic Follow-Up of a Cohort of Smokers Who Received a Standard Smoking Cessation Intervention with Soft Laser Therapy
- Antidiabetic Activity Assessment of Argania spinosa Oil
- Crude Extract of Turmeric Reduces Hepato-Toxicity and Oxidative Stress in Rats Chronically Fed Carcinogens
- Cardioprotective Activity of Polyherbal Extracts in Experimental Myocardial Necrosis in Rodents: An Evidence of Antioxidant Activity
- Position Paper
- Increasing Research Literacy and Capacity in Massage Therapy: Investigating the Feasibility of a Peer-Reviewed International, Electronic Massage Therapy Journal
- Conference Presentation
- Research that Matters: Linking Researchers, Practitioners, Decision-Makers and the Public: Abstracts from the Fifth Annual IN-CAM Research Symposium November 7 to 9, 2008, Toronto, Canada
Schlagwörter für diesen Artikel
herbal product;
hypolipidemic activity;
Hyperlipidemia;
experimental rat models;
rats;
cardiovascular diseases;
cardiovascular risks
Artikel in diesem Heft
- Review Article
- Potential Health Benefits of Garlic (Allium Sativum): A Narrative Review
- Effect of Pranayama [Voluntary Regulated Yoga Breathing] and Yogasana [Yoga Postures] in Diabetes Mellitus (DM): A Scientific Review
- Research Advances on the Anti-aging Profile of Fructus lycii: an Ancient Chinese Herbal Medicine
- Complementary and Alternative Medicine Use in Juvenile Idiopathic Arthritis: A Systematic Review of Prevalence and Evidence
- Research Article
- Effects of Harungana madagascariensis Stem Bark Extract on the Antioxidant Markers in Alloxan Induced Diabetic and Carrageenan Induced Inflammatory Disorders in Rats
- Effect of Some Ayurvedic Vajikaran Rasayana Herbs on Heat Induced Testicular Damage in Male Albino Rats
- An Extract from North American Ginseng Stimulates Spontaneous Immunity in Infant Mice: Sustained, Augmented Immunity in Adulthood Long after Withdrawal of the Extract
- Cardiovascular and Anti-Platelet Aggregation Activities of Extracts from Solanum torvum (Solanaceae) Fruits in Rat
- Evaluation of Antioxidant and Free Radical Scavenging Activities of Oxystelma esculentum in Various In Vitro Models
- The Antioxidant Defense System Induced by Methanol Extract of Careya arborea in N-Nitroso-diethylamine (NDEA) Induced Hepatocarcinogenesis
- Inhibition of Carbohydrate Digestive Enzymes by Talinum portulacifolium (Forssk) Leaf Extract
- Magnetotherapy: Changes in the Nature of Biomolecules under a Constant Magnetic Field
- Inhalation of Neroli Essential Oil and Its Anxiolytic Effects
- Protective Role of Grewia asiatica on Blood after Radiation Exposure in Mice
- Lepidium meyenii (Maca) Varieties Did Not Alter Female Reproductive Parameters in Adult Intact Rats
- Hypolipidemic Activity Evaluation of DRF/AY/4013, an Herbal Formulation in Experimentally Induced Hyperlipidemic Rats
- Slimpid May Boost Plasma IGF-1 Level and Improve the Quality of Life in Patients with Risk of Developing Metabolic Syndrome
- Effect of Argan Oil on Platelet Aggregation and Bleeding Time: A Beneficial Nutritional Property
- Comparative Analysis of CAM Use in the U.S. Cancer and Noncancer Populations
- Antiangiogenic Effects of Chinese Medicines (Hachimijiogan and Kogikujiogan) on Vascular Endothelial Growth Factor-A-Induced Tube Formation in Human Umbilical Vein Endothelial Cells Co-Cultured with Fibroblasts
- Evaluation of the Antioxidant Activity and Lipid Peroxidation of the Leaves of Vernonia amygdalina
- Heart Rate Dynamics during Shambhavi Mahamudra- A Practice of Isha Yoga
- The Effects of Borage Oil Supplementation on Non-Steroidal Anti-Inflammatory Drug Requirements in Patients with Rheumatoid Arthritis
- Australian Natural Therapists and Mental Health: Survey of Treatment Approaches and Referral Patterns
- Tinospora cordifolia Protects Mouse Peritoneal Macrophages From LPS-induced Death
- Antioxidant and Acetylcholinesterase Inhibitory Properties of the Indian Medicinal Plant "Shankhapushpi" Used for Enhancing Memory Function
- Effect of Concomitant Administration of Aqueous Extract of Pleurotus pulmonarius and Metformin in Diabetic Mice
- Anti-Adipogenic Activity of Capsicum annum (Solanaceae) in 3T3 L1
- Hypoglycemic Activity of Aqueous Extract of Oscillatoria limnetica, Blennothrix ganeshii, Hydrodictyon reticulatum and Microcoleous lacustris in Normal and Alloxan Induced Diabetic Mice
- Systematic Follow-Up of a Cohort of Smokers Who Received a Standard Smoking Cessation Intervention with Soft Laser Therapy
- Antidiabetic Activity Assessment of Argania spinosa Oil
- Crude Extract of Turmeric Reduces Hepato-Toxicity and Oxidative Stress in Rats Chronically Fed Carcinogens
- Cardioprotective Activity of Polyherbal Extracts in Experimental Myocardial Necrosis in Rodents: An Evidence of Antioxidant Activity
- Position Paper
- Increasing Research Literacy and Capacity in Massage Therapy: Investigating the Feasibility of a Peer-Reviewed International, Electronic Massage Therapy Journal
- Conference Presentation
- Research that Matters: Linking Researchers, Practitioners, Decision-Makers and the Public: Abstracts from the Fifth Annual IN-CAM Research Symposium November 7 to 9, 2008, Toronto, Canada
