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The Antioxidant Defense System Induced by Methanol Extract of Careya arborea in N-Nitroso-diethylamine (NDEA) Induced Hepatocarcinogenesis
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Ramanathan Sambath Kumar
Veröffentlicht/Copyright:
21. Mai 2008
The methanol extract of stem barks of Careya arborea Roxb (MECA) (Family- Myrtaceae) was evaluated against hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA). NDEA is a widely used experimental tool to induce cancer in animals causing oxidative stress and cellular injury due to the enhanced formation of free radicals and is associated with rise in biochemical parameters like serum glutamyl pyruvate transaminase (SGPT), serum glutamyl oxalacetic acid (SGOT), serum alkaline phosphatase (SALP), bilirubin, as well as decrease in the levels of total protein and uric acid. Furthermore, the protective effect of Careya arborea against perturbations in the levels of antioxidant defense system was also estimated. The MECA was administered at the doses of 100 and 200 mg/kg body weight/rat in alternative days for 8 weeks. At the end of the drug schedule, rats were sacrificed and the effect of MECA on visible macroscopic (Morphometry) liver lesion (neoplastic nodules) and the level of SGPT, SGOT, SALP, bilirubin, total protein, uric acid and liver antioxidant defense parameters like lipid peroxidation (LPO), nonenzymatic antioxidant such as glutathione content (GSH), vitamin C, vitamin E and enzymatic antioxidant like superoxide dismutase (SOD) and catalase (CAT) were estimated. The MECA was found to be protective against NDEA-induced carcinoma by decreasing the activity of serum enzymes, bilirubin and increase the protein and uric acid levels. MECA significantly decreased the levels of LPO, while it significantly increased the levels of GSH, vitamin C, vitamin E, SOD and CAT. The results indicate that MECA exhibited significant chemopreventive effects by suppressing nodules development and enhancing the antioxidants in NDEA carcinogenesis by reducing the formation of free radicals.
Keywords: Careya arborea; N-nitrosodiethylamine (NDEA); anti-carcinogenic activity; biochemical parameters; antioxidants
Published Online: 2008-5-21
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Schlagwörter für diesen Artikel
Careya arborea;
N-nitrosodiethylamine (NDEA);
anti-carcinogenic activity;
biochemical parameters;
antioxidants
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