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(Z) phényl-1 diéthylaminocarbonyl-1 aminométhyl-2 cyclopropane (Midalcipran): Etude structurale comparative des variétés Cis, Trans I et Trans II
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August 25, 2010
Abstract
The comparative crystal study of the title compound Midalcipran, Et2N – C(O) – C(Ph) – CH(CH2) in its active Cis-form with its trans isomer form crystallizing under two varieties, Trans I and Trans II, has been carried out for a better understanding of the mechanism of its antidepressant activity. The crystal data have also been compared with existing theoretical CNDO/2 studies. The Cis-form crystallizes in the orthorhombic system, Trans I is monoclinic and Trans II triclinic. Their crystal structures have been determined using conventional X-ray single crystal analysis. The active compound is characterized by a strong intramolecular hydrogen bond.
Published Online: 2010-8-25
Published in Print: 1986-1-1
© 2015 Oldenbourg Wissenschaftsverlag GmbH, Rosenheimer Str. 145, 81671 München
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Articles in the same Issue
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- The crystal structure of β-Mg2PO4OH, a synthetic hydroxyl analogue of wagnerite
- Structural change of orthorhombic-I tridymite with temperature: A study based on second-order thermal-vibrational parameters
- High-order thermal-motion tensor analyses of tridymite
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- Crystal structure and spectra of trans-dichloro-p-chlorobenzoyldi-(2-pyridyl)ketonohydrazono antimony(III)
- Orientational disorder in cubic CsNO2 by neutron powder diffraction
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