Effect of a spacer moiety on radiometal labelled Neurotensin derivatives
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A. Mascarin
Abstract
The binding sequence of the regulatory peptide Neurotensin, NT(8-13), represents a promising tumour-specific vector for the development of radiopeptides useful in nuclear oncology for the diagnosis (imaging) and therapy of cancer. A number of radiometal-labelled NT(8-13) derivatives have been reported, however, the effect of the spacer which connects the vector with the radiometal complex has yet not been investigated systematically. Because a spacer moiety can influence potentially important biological characteristics of radiopeptides, we synthesized three [DOTA(177Lu)]-X-NT(8-13) derivatives and evaluated the effect of a spacer (X) on the physico-chemical properties of the conjugate including lipophilicity, stability, and in vitro receptor affinity and cell internalization.
© 2013 by Walter de Gruyter Berlin Boston
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- MicroSISAK: continuous liquid–liquid extractions of radionuclides at 0.2 mL/min
- Crystal structure and spectral properties of complexes of tetravalent Th, U, Np and Pu nitrates with trimethyl phosphate and dimethyl phosphate
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- Effect of a spacer moiety on radiometal labelled Neurotensin derivatives
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Artikel in diesem Heft
- Masthead
- Masthead
- MicroSISAK: continuous liquid–liquid extractions of radionuclides at 0.2 mL/min
- Crystal structure and spectral properties of complexes of tetravalent Th, U, Np and Pu nitrates with trimethyl phosphate and dimethyl phosphate
- Heterogeneous reduction of 239PuO2 by aqueous Fe(II) in the presence of hematite
- New alkyl-pyridinedicarboxyamides as extractants for separationof trivalent minor actinides from fission products by extraction chromatography
- Liquid–liquid extraction of Np4+ and Pu4+ using several tetra-alkyl substituted diglycolamides
- Ion-imprinted polymeric nanoparticles as a novel sorbent to separate radioyttrium from Sr target
- Effect of a spacer moiety on radiometal labelled Neurotensin derivatives
- Investigaton of Kpong carbonatite as a potential source for rare earth elements (REEs) using instrumental neutron activation analysis (INAA)
- Precise age determination of a single plutonium particle using inductively coupled plasma mass spectrometer
