Isolation of hydroxytyrosol from olive leaves extract, radioiodination and investigation of bioaffinity using in vivo/in vitro methods
-
M. Ozkan
,
A. Yurt Kilcar
Summary
It is known that medicinal plants like olive have biological activities due to their flavonoid content such as olueropein, tyrosol, hydroxytyrosol etc. In current study, hydroxytrosol (HT) which is one of the major phenolic compounds in olive, olive leaves and olive oil, was isolated after methanol extraction and purification of olive leaves which are grown in the northern Anatolia region of Turkey. The isolated HT was radiolabeled with 131I (131I-HT) and the bioaffinity of this radiolabeled component of olive leaves extract was investigated by using in vivo/in vitro methods. It was found that HT could be radiolabeled with 131I in yields of 95.6±4.4% (n = 8), and in vivo studies showed that 131I-HT is taken up by urinary bladder, stomach, small intestine, large intestine, breast and prostate. Significant incorporation of activity was observed in cell lines via in vitro studies.
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Artikel in diesem Heft
- Measurement of bremsstrahlung-induced reaction cross-section for 93Nb using electron Linac
- Electrolytic partitioning of uranium and plutonium based on a new type of electrolytic mixer-settler
- Influence of humic acid on neptunium(V) sorption and diffusion in Opalinus Clay
- Quantum chemical study of inner-sphere complexes of trivalent lanthanide and actinide ions on the corundum (110) surface
- Synthesis and preliminary pharmacological evaluation of a new putative radioiodinated AMPA receptor ligand for molecular imaging
- Synthesis, radiolabeling and quality control of 111In-DOTA-bevacizumab for radioimmunoscintigraphy of VEGF receptors
- Isolation of hydroxytyrosol from olive leaves extract, radioiodination and investigation of bioaffinity using in vivo/in vitro methods
- Gold-coated lanthanide phosphate nanoparticles for an 225Ac in vivo alpha generator
- Interferences in instrumental neutron activation analysis by threshold reactions and uranium fission for miniature neutron source reactor
