Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO2(VI) and Th(IV) decorporation
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M. Sturzbecher-Hoehne
Abstract
Solution thermodynamic studies were performed to characterize the coordination of U(VI) and Th(IV) by the multidentate hydroxypyridinonate chelating agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Species distribution and conditional stability pM profiles were calculated based on the determined formation constants, showing that both ligands form extremely stable uranyl and thorium complexes in solution. At physiological pH, the formation of 1:1 ligand:uranyl complexes is favored for both ligands, while a 2:1 ligand:thorium complex is predominant with the tetradentate 5-LIO(Me-3,2-HOPO). Comparisons with functionally similar bidentate ligands as well as with the common actinide chelator diethylenetriamine pentaacetic acid emphasized the superior affinity for U(VI) and Th(IV) of both experimental compounds over a wide pH range. These analytical results corroborate the in vivo chelation efficacy of 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) and validate their selection for further development as therapeutic actinide decorporation agents.
© by Oldenbourg Wissenschaftsverlag, München, Germany
Artikel in diesem Heft
- Preface
- Analytical tools for speciation in the field of toxicology
- Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO2(VI) and Th(IV) decorporation
- Short note on the hydrolysis and complexation of neptunium(IV) in HEPES solution
- Contribution of extraction isotherms modeling based on the Mikulin–Sergievskii–Dannus approach to the speciation of plutonium(IV) in TBP 30 %/dodecane
- EXAFS investigation on U(VI) immobilization in hardened cement paste: influence of experimental conditions on speciation
- Uranium(VI) solubility in carbonate-free WIPP brine
Artikel in diesem Heft
- Preface
- Analytical tools for speciation in the field of toxicology
- Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO2(VI) and Th(IV) decorporation
- Short note on the hydrolysis and complexation of neptunium(IV) in HEPES solution
- Contribution of extraction isotherms modeling based on the Mikulin–Sergievskii–Dannus approach to the speciation of plutonium(IV) in TBP 30 %/dodecane
- EXAFS investigation on U(VI) immobilization in hardened cement paste: influence of experimental conditions on speciation
- Uranium(VI) solubility in carbonate-free WIPP brine
