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New separation method of no-carrier-added 47Sc from titanium targets

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Published/Copyright: April 10, 2012
Radiochimica Acta
From the journal Radiochimica Acta Volume 100 Issue 7

Abstract

Radionuclides with medium energy beta emission and a several day half-life are attractive candidates for radioimmunotherapy. Among the most promising in this category is 47Sc produced by fast neutron irradiation (En>1 MeV) of titanium target with high energy neutrons in 47Ti(n,p) 47Sc nuclear reaction. In the previously reported production scheme the dissolution of the TiO2 target in hot concentrated H2SO4 and evaporation of the resulting solution were the most time-consuming steps. The present paper describes new, simple and efficient production method of 47Sc, where the slow dissolution of the target is avoided. After irradiation in fast neutron flux 47TiO2 and Li247TiF6 targets were dissolved in HF solutions. Next 47Sc was separated from the target using anion exchange resin Dowex 1 with 0.4 M HF + 0.06 M HNO3 solution as eluent. The eluted 47Sc was adsorbed on cation exchange resin and eluted with 0.5 M of ammonium acetate. The 47Sc separation yield in the proposed procedure is about 90% with the separation time less than 2 h. The obtained no-carrier-added 47Sc was used to label DOTATATE conjugate with 96% labeling yield.

Keywords: Scandium radionuclides; SC-47 radiobioconjugates; Radionuclide therapy
* Correspondence address: Institute of Nuclear Chemistry and Technology, Department of Radiochemistry, Dorodna 16, 03-195 Warszawa, Polen,
Published Online: 2012-04-10
Published in Print: 2012-07

© by Oldenbourg Wissenschaftsverlag, Warszawa, Germany

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  2. Preparation of 67Cu via deuteron irradiation of 70Zn
  3. Mutual separation of americium(III) and europium(III) using glycolamic acid and thioglycolamic acid
  4. Comparison of two sequential separation methods for U and Th determination in environmental samples by alpha-particle spectrometry
  5. Selective separation of actinyl(V,VI) cations from aqueous solutions by Chelex-100
  6. Kinetics of hydrogen peroxide consumption in aqueous phase at different hydrogen partial pressures
  7. The influence of pH on the sorption and diffusion of 99TcO4− in Beishan granite
  8. New separation method of no-carrier-added 47Sc from titanium targets
  9. A novel 99mTc-labeled dimethyl-substituted zoledronic acid (DMIDP) with improved bone imaging efficiency
  10. Polymersomes as nano-carriers to retain harmful recoil nuclides in alpha radionuclide therapy: a feasibility study
https://doi.org/10.1524/ract.2012.1938
Keywords for this article
Scandium radionuclides; SC-47 radiobioconjugates; Radionuclide therapy

Articles in the same Issue

  1. Historical Item
  2. Preparation of 67Cu via deuteron irradiation of 70Zn
  3. Mutual separation of americium(III) and europium(III) using glycolamic acid and thioglycolamic acid
  4. Comparison of two sequential separation methods for U and Th determination in environmental samples by alpha-particle spectrometry
  5. Selective separation of actinyl(V,VI) cations from aqueous solutions by Chelex-100
  6. Kinetics of hydrogen peroxide consumption in aqueous phase at different hydrogen partial pressures
  7. The influence of pH on the sorption and diffusion of 99TcO4− in Beishan granite
  8. New separation method of no-carrier-added 47Sc from titanium targets
  9. A novel 99mTc-labeled dimethyl-substituted zoledronic acid (DMIDP) with improved bone imaging efficiency
  10. Polymersomes as nano-carriers to retain harmful recoil nuclides in alpha radionuclide therapy: a feasibility study
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