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[201Tl](III)-bleomycin for tumor imaging
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A. R. Jalilian
Veröffentlicht/Copyright:
25. September 2009
Summary
Due to interesting physical properties and wide availability of thallium-201 as a SPECT radionuclide, the idea of incorporation of this nuclide into biologically active compounds was targeted. Thallium-201 (T1/2 = 3.04 d) in Tl+ form was converted to Tl3+ cation in presence of O3 in 6 M HCl controlled by RTLC/gel electrophoresis methods. The final evaporated activity was reacted with bleomycin in normal saline to yield [201Tl]BLM at room temperature after 0.5 h (radiochemical yield > 99%) followed by HPLC analysis. The studies showed that thallic ion is mostly incorporated into bleomycin A2 while other species in the pharmaceutical sample almost remain unlabeled. Radiochemical purity of more than 99% was obtained using RTLC, HPLC with specific activity of about 7 Ci/mmol. The stability of the tracer was checked in the final product in presence of human serum at 37 °C up to 3 d. The tracer accumulated in tumors of fibrosarcoma-bearing mice after 72 h.
Received: 2006-1-24
Accepted: 2006-5-3
Published Online: 2009-9-25
Published in Print: 2006-8-1
© Oldenbourg Wissenschaftsverlag
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Schlagwörter für diesen Artikel
201Tl(III)-complexation;
Bleomycin;
Biodistribution;
SPECT;
Fibrosarcoma
Artikel in diesem Heft
- Measurement of fission neutron spectrum averaged cross sections of some threshold reactions on zirconium: Production possibility of no-carrier-added 90Y in a nuclear reactor
- Measurement of thermal neutron cross sections of the reactions 126Sn(n, γ)127g,127mSn
- Excitation functions of proton induced nuclear reactions on natural copper using a medium-sized cyclotron
- Precise and accurate determination of alpha decay half-life of 244Pu by relative activity method using thermal ionization mass spectrometry and alpha spectrometry
- Measurement of the half-life of 132I
- Theoretical predictions of complex formation of group-4 elements Zr, Hf, and Rf in H2SO4 solutions
- Electrochemical behavior of uranium(VI) in 1-butyl-3-methylimidazolium chloride and in 0.05 M aliquat-336/chloroform
- Retention of Sn(IV) and Pu(IV) onto four argillites from the Callovo–Oxfordian level at Bure (France) from eight equilibrated sedimentary waters
- Influence of soil humic acid and fulvic acid on sorption of thorium(IV) on MX-80 bentonite
- Sorption characteristics of 99Tc onto bentonite material with different additives under anaerobic conditions
- Studies on sorption of cadmium (II) ions onto Haro river sand from aqueous media using radiotracer and voltammetric techniques
- Simplified, automated synthesis of 3′[18F]fluoro-3′-deoxy-thymidine ([18F]FLT) and simple method for metabolite analysis in plasma
- [201Tl](III)-bleomycin for tumor imaging
- Separation of uranium(VI) from tri- and tetravalent elements in phosphoric acid solutions
- Substoichiometric extraction of iron by 2-methyloxine into n-butanol
- Determination of stability constants of lanthanide nitrate complex formation using a solvent extraction technique
- Synergistic extraction of Nd(III), Tb(III) and Lu(III) ions with a mixture of picrolonic acid and benzo-15-crown-5 in chloroform
- A simplified reaction model predicting the effect of some parameters on the degradation of phenol in the electron beam process
