Synthesis, radiolabelling characteristics and biological evaluation of the derivatives of mercaptoacetyltriglycine
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S. M. Okarvi
Summary
Several derivatives of MAG3, in which one or both of the first two amide bonds are inverted and contain an additional methyl or carboxyl-substituent on the ligand backbone, have been synthesized and evaluated. This was realized by substituting a glycyl with a D- or L-alanyl moiety or by replacing cysteamine with an L-cysteine to investigate the renal characteristics of the resulting derivatives versus the reference 99mTc-MAG3. Labelling with 99mTc resulted in two main radioactive species, which probably are the isomeric oxo-technetium complexes. These complexes were separated by HPLC and evaluated in mice. The data suggest that the substitution in the amide functions and addition of a methyl or carboxyl moiety results in poor renal handling of these compounds. However, one of the derivatives 99mTc-C-LB, exhibits renal characteristics comparable to 99mTc-MAG3.
© Oldenbourg Wissenschaftsverlag, München
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Artikel in diesem Heft
- Photofission of 209Bi at intermediate energies
- Synergistic extraction of uranium(VI) by bis(2,4,4-trimethylpentyl) phosphini acid in the presence of neutral oxo-donors
- Analysis of 237Np in spent fuel solutions
- The solubilisation of Ru and U from condensation particles released b overheated nuclear fuel and maturated in air and in argon
- Contrary effects of the water radiolysis product H2O2 upon th dissolution of nuclear fuel in natural ground water and deionized water
- Accelerator mass spectrometry dating at Çatalhöyük
- Radiochemical separation of no-carrier-added radioniobium from zirconiu targets for application of 90Nb-labelled compounds
- Separation of pertechnetate from molybdate by anion-exchange chromatography: Recovery of 99mTc from (n, γ)99Mo and suitability for use in central radiopharmacy (CRPh)
- Synthesis, radiolabelling characteristics and biological evaluation of the derivatives of mercaptoacetyltriglycine
