Probing Inclusion Complexes of Pentoxifylline and Pralidoxim inside Cyclic Oligosaccharides by Physicochemical Methodologies
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Biraj Kumar Barman
Abstract
Structurally different Molecules namely Pentoxifylline and Pralidoxim were chosen along with α-cyclodextrin and β-cyclodextrin to study host-guest inclusion phenomena. The formations of host guest inclusion complexes were confirmed by studying 1H-NMR spectra, FT-IR spectra, apparent molar volume and viscosity co-efficient. The stabilities of inclusion complexes were compared calculating the binding constant from UV-VIS spectroscopic study. The 1:1 stoichiometry of the inclusion complexes were also determined by analysing the Jobs plot and surface tension data. The values for Gibbs’ free energy were found negative for both the processes. Based on all the above experiments the inclusion processes were found feasible for both the compounds. These types of inclusion complexes are of high interest in the field of research and industry as these are used as drug delivery systems.
Acknowledgement
Authors are grateful to University Grants Commission, New Delhi, India (No. 540/27/DRS/2007, SAP-DSR) and UGC-RGNF India (No. F117.1/201617/RGNF201517SCWES1846 and F.1/2012-13/RGNF-2012-13-SC-WES-17229) for financial and instrumental support to perform this research work. Prof. M. N. Roy is grateful to the UGC, New Delhi, Govt. of India, for being awarded one-time grant under the Basic Scientific Research by the Grant-in-Aid no. F4-10/2010 (BSR) regarding his active service for expanding research facilities to help further research work.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/zpch-2017-1020).
©2019 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Hydrogen Bond Interaction of Ascorbic Acid with Urea: Experimental and Theoretical Study
- The Thermodynamic and Binding Studies of Hg+2 Ions with Egg Protein by Polarographic and pH Metric Techniques
- Effect of Maltodextrin and Temperature on Micellar Behavior of Bile Salts in Aqueous Medium: Conductometric and Spectrofluorimetric Studies
- Probing Inclusion Complexes of Pentoxifylline and Pralidoxim inside Cyclic Oligosaccharides by Physicochemical Methodologies
- Solubility and Solution Thermodynamics of Baricitinib in Six Different Pharmaceutically Used Solvents at Different Temperatures
- One-Pot Synthesis and Rheological Study of Cationic Poly (3-acrylamidopropyltrimethyl ammoniumchloride) P(APTMACl) Polymer Hydrogels
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