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Green synthesized AgNPs of the Anchusa arvensis aqueous extract resulting in impressive protein kinase, antioxidant, antibacterial, and antifungal activities

  • Mohamed Mohany , Jamshed Ali , Abdul Wahab EMAIL logo , Fozia Fozia ORCID logo EMAIL logo , Syed Majid Shah , Rukhsana Gul , Ahmad Gul , Ijaz Ahmad , Marija Milošević , Salim S. Al-Rejaie and Mourad A. M. Aboul-Soud
Published/Copyright: September 27, 2024
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Zeitschrift für Naturforschung C
From the journal Zeitschrift für Naturforschung C Volume 80 Issue 5-6

Abstract

This study focused on analyzing the pharmacological activities of AgNPs synthesized from an aqueous plant extract of Anchusa arvensis. The effectiveness of AgNPs was evaluated for protein kinase inhibition, antioxidant, antibacterial, and antifungal activities. The AgNPs and plant were used to regulate the protein kinase activity using the liquid TSB and ISP4 medium protein kinase inhibition study demonstrated that nanoparticles exhibited a larger zone of inhibition (9.1 ± 0.8) compared to the plant extract (8.1 ± 0.6). The antioxidant activity was assessed using DPPH reagent, and the results indicated that AgNPs displayed potent free radical scavenging properties. In terms of antibacterial activity, AgNPs showed higher efficacy against Enterobacter aerogens (20.1 ± 0.9), Bordetella bronchiseptaca (19.1 ± 0.9), and Salmonella typhimurium (17.2 ± 0.8) at 4 mg/mL. The antifungal activity of AgNPs was prominent against Aspergillus fumagatus (14.1 ± 0.9), Mucor species (19.2 ± 0.8), and Fusarium solani (11.2 ± 0.8) at 20 mg/mL. These findings suggest that AgNPs possess multiple beneficial properties, including bactericidal/fungicidal effects, protein kinase inhibition, and potential free radical scavenging abilities. Therefore, AgNPs have potential applications in various fields, such as biomedicine and industry, due to their ability to counteract the harmful effects of free radicals.

Keywords: protein kinase inhibition; antioxidant; antibacterial; antifungal activities; Anchusa arvensis ; silver nanoparticles
Corresponding authors: Abdul Wahab, Department of Pharmacy, Kohat University of Science & Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan, E-mail: ; and Fozia Fozia, Department of Biochemistry, Khyber Medical University Institute of Dental Sciences, Kohat 26000, Khyber Pakhtunkhwa, Pakistan, E-mail:

Funding source: King Saud University

Award Identifier / Grant number: Researchers Supporting Project (RSP2024R120)

  1. Research ethics: Not applicable.

  2. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  4. Conflict of interest: The authors declare no conflicts of interest.

  5. Research funding: The authors extend their appreciation to the Researchers Supporting Project number (RSP2024R120), King Saud University, Riyadh, Saudi Arabia.

  6. Data availability: All the relevant data generated during this research is already mentioned in the manuscript.

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Received: 2024-06-26
Accepted: 2024-09-13
Published Online: 2024-09-27
Published in Print: 2025-05-26

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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  2. Review Articles
  3. Nourishment beyond grains: unveiling the multifaceted contributions of millets to United Nations Sustainable Development Goals
  4. Exploring the functionality of fluorescent liposomes in cancer: diagnosis and therapy
  5. Research Articles
  6. In vitro antibacterial activities, DPPH radical scavenging, and molecular simulation of isolated compounds from the leaves of Rhus ruspolii
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  9. Molecular mechanisms of the anticancer action of fustin isolated from Cotinus coggygria Scop. in MDA-MB-231 triple-negative breast cancer cell line
  10. Green synthesized AgNPs of the Anchusa arvensis aqueous extract resulting in impressive protein kinase, antioxidant, antibacterial, and antifungal activities
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https://doi.org/10.1515/znc-2024-0148
Keywords for this article
protein kinase inhibition; antioxidant; antibacterial; antifungal activities; Anchusa arvensis; silver nanoparticles

Articles in the same Issue

  1. Frontmatter
  2. Review Articles
  3. Nourishment beyond grains: unveiling the multifaceted contributions of millets to United Nations Sustainable Development Goals
  4. Exploring the functionality of fluorescent liposomes in cancer: diagnosis and therapy
  5. Research Articles
  6. In vitro antibacterial activities, DPPH radical scavenging, and molecular simulation of isolated compounds from the leaves of Rhus ruspolii
  7. Characterization and antimicrobial activity of essential oils extracted from lemongrass (Cymbopogon flexuosus) using microwave-assisted hydro distillation
  8. In silico DFT and molecular modeling of novel pyrazine-bearing thiazolidinone hybrids derivatives: elucidating in vitro anti-cancer and urease inhibitors
  9. Molecular mechanisms of the anticancer action of fustin isolated from Cotinus coggygria Scop. in MDA-MB-231 triple-negative breast cancer cell line
  10. Green synthesized AgNPs of the Anchusa arvensis aqueous extract resulting in impressive protein kinase, antioxidant, antibacterial, and antifungal activities
  11. Phytochemical composition, antimicrobial, antioxidant, and wound healing activities of Thermopsis turcica
  12. Molecular detection of Coxiella burnetii infection (Q fever) in livestock in Makkah Province, Saudi Arabia
  13. Spermidine protects cellular redox status and ionic homeostasis in D-galactose induced senescence and natural aging rat models
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