Startseite Chemical composition and the anti-inflammatory effect of volatile compounds from Anaxagorea luzonensis A. Gray
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Chemical composition and the anti-inflammatory effect of volatile compounds from Anaxagorea luzonensis A. Gray

  • Gia Buu Tran , Ty Viet Pham ORCID logo , Anh Tuan Le , Nguyen Hoai Nguyen , Nguyen Huy Hoang Vo und Bich Hang Do EMAIL logo
Veröffentlicht/Copyright: 14. Juni 2024
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Zeitschrift für Naturforschung C
Aus der Zeitschrift Zeitschrift für Naturforschung C Band 79 Heft 9-10

Abstract

Anaxagorea luzonensis A. Gray, a member of the Annonaceae family, has been used to treat a variety of illnesses for a long time. For the first time, A. luzonensis volatile compounds (ALVCs) were extracted from the leaves, and the components were identified using gas chromatography-mass spectrometry (GC-MS). Further, the main compositions of ALVCs were also assessed for their ability to bind with anti-inflammatory proteins using a docking model. In addition, in vitro tests e.g. inhibition of protein degradation and the inhibition of nitric oxide release using RAW264.7 macrophage cells were utilized for evaluating the anti-inflammatory activity. The results showed that the principal compounds of ALVCs were bulnesol (34.1 %), cubitene (17.8 %), β-eudesmol (10.4 %), epi-longipinanol (5.9 %), and (Z)-nerolidyl acetate (5.5 %). Three compounds viz. bulnesol, cubitene, and β-eudesmol bound firmly to cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), as shown by the in silico analysis, similar to the positive control diclofenac. ALVCs effectively inhibited protein degradation with the IC50 of 31 ± 2.3 μg/mL and inhibited nitric oxide production with the IC50 of 43.30 ± 3.37 μg/mL. These findings showed that ALVCs might have a promising anti-inflammatory effect by blocking several inflammatory proteins.

Keywords: anti-inflammation; A. luzonensis A. Gray; volatile compounds; GC-MS; docking study; inhibition of NO release
Corresponding author: Bich Hang Do, Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam, E-mail:

Funding source: Ton Duc Thang University

Award Identifier / Grant number: 3633/QD-TDT 19/12/2022

Acknowledgments

The authors would like express their gratitude to Dr. Thien-Y Vu, Faculty of Pharmacy, Ton Duc Thang University, Vietnam for his support in docking study of the research project.

  1. Research ethics: Not applicable.

  2. Author contributions: Conceptualization and experiment design: Gia Buu Tran, Ty Viet Pham, Anh Tuan Le, Hoai Nguyen Nguyen, Nguyen Huy Hoang Vo, Bich Hang Do. Data curation & visualization: Huy Hoang Nguyen Vo, Gia Buu Tran, Bich Hang Do. Formal analysis: Anh Tuan Le, Hoai Nguyen Nguyen, Bich Hang Do. Writing-original draft: Ty Viet Pham, Anh Tuan Le, Hoai Nguyen Nguyen, Nguyen Huy Hoang Vo, Gia Buu Tran, Bich Hang Do. Review-editing: Bich Hang Do. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors state no conflict of interest.

  4. Research funding: This work was supported by Ton Duc Thang University under (3633/QD-TDT 19/12/2022).

  5. Data availability: The raw data can be obtained on a reasonable request from the corresponding author.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/znc-2023-0177).

Received: 2023-12-05
Accepted: 2024-03-08
Published Online: 2024-06-14
Published in Print: 2024-09-25

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/znc-2023-0177
Schlagwörter für diesen Artikel
anti-inflammation; A. luzonensis A. Gray; volatile compounds; GC-MS; docking study; inhibition of NO release

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Navigating the landscape of theranostics in nuclear medicine: current practice and future prospects
  4. Research Articles
  5. Insecticidal effect of new synthesized chalcone derivatives on Caribbean fruit fly, Anastrepha suspensa
  6. Cymbopogon proximus phytochemicals induce S-phase arrest in A549 lung cancer cell lines via CDK2/cyclin A2 inhibition: gas chromatography-mass spectrometry and molecular docking analyses
  7. Chemical constituents from the Saposhnikovia divaricata and their antiproliferative activity
  8. Development and assessment of novel pyrazole–thiadiazol hybrid derivatives as VEGFR-2 inhibitors: design, synthesis, anticancer activity evaluation, molecular docking, and molecular dynamics simulation
  9. In vitro antibacterial and antioxidant activity of flavonoids from the roots of Tephrosia vogelii: a combined experimental and computational study
  10. Chemical composition and the anti-inflammatory effect of volatile compounds from Anaxagorea luzonensis A. Gray
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