Sakuranetin and its therapeutic potentials – a comprehensive review

Md. Junaid; Bristy Basak; Yeasmin Akter; Syeda Samira Afrose; Afsana Nahrin; Rashiduzzaman Emran; Md. Shahinozzaman; Shinkichi Tawata

doi:10.1515/znc-2022-0024

Article

Sakuranetin and its therapeutic potentials – a comprehensive review

Md. Junaid , Bristy Basak , Yeasmin Akter , Syeda Samira Afrose , Afsana Nahrin , Rashiduzzaman Emran , Md. Shahinozzaman and Shinkichi Tawata

Published/Copyright: July 13, 2022

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From the journal Zeitschrift für Naturforschung C Volume 78 Issue 1-2

Abstract

Sakuranetin (SKN), a naturally derived 7-O-methylated flavonoid, was first identified in the bark of the cherry tree (Prunus spp.) as an aglycone of sakuranin and then purified from the bark of Prunus puddum. It was later reported in many other plants including Artemisia campestris, Boesenbergia pandurata, Baccharis spp., Betula spp., Juglans spp., and Rhus spp. In plants, it functions as a phytoalexin synthesized from its precursor naringenin and is the only known phenolic phytoalexin in rice, which is released in response to different abiotic and biotic stresses such as UV-irradiation, jasmonic acid, cupric chloride, L-methionine, and the phytotoxin coronatine. Till date, SKN has been widely reported for its diverse pharmacological benefits including antioxidant, anti-inflammatory, antimycobacterial, antiviral, antifungal, antileishmanial, antitrypanosomal, glucose uptake stimulation, neuroprotective, antimelanogenic, and antitumor properties. Its pharmacokinetics and toxicological properties have been poorly understood, thus warranting further evaluation together with exploring other pharmacological properties such as antidiabetic, neuroprotective, and antinociceptive effects. Besides, in vivo studies or clinical investigations can be done for proving its effects as antioxidant and anti-inflammatory, antimelanogenic, and antitumor agent. This review summarizes all the reported investigations with SKN for its health-beneficial roles and can be used as a guideline for future studies.

Keywords: flavonoid; naringenin; Prunus spp.; Sakuranetin; therapeutic potential

Corresponding author: Dr. Md. Shahinozzaman, PAK Research Center, University of the Ryukyus, Senbaru 1, Nishihara-cho, Okinawa 903-0213, Japan, E-mail: k0407500@kadai.jp

Md. Junaid and Bristy Basak have contributed equally to this manuscript.

Acknowledgments

M. Shahinozzaman would like to thank Professor Shinkichi Tawata, Director, PAK Research Center, University of the Ryukyus, Japan and the Biosystem Consulting, Ltd., Okinawa, Japan for providing continuous research support.

Author contributions: MJ, YA, SSA, and AN wrote the initial draft for the pharmacological properties of sakuranetin. BB improved the initial draft and wrote the draft of the abstract, introduction, conclusion, table, and figures. RE revised the figures and revised the initial draft. MS conceived the idea, designed the plan, and edited the whole manuscript to improve it. ST critically evaluated the review plan and revised the whole manuscript before final submission.
Research funding: This work received no direct funding.
Conflict of interest statement: Authors declare no conflict of interest.

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Received: 2022-02-03

Accepted: 2022-06-10

Published Online: 2022-07-13

Published in Print: 2023-01-27

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Articles in the same Issue

https://doi.org/10.1515/znc-2022-0024

Keywords for this article

flavonoid; naringenin; Prunus spp.; Sakuranetin; therapeutic potential