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Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds

  • Naime Funda Tay ORCID logo EMAIL logo , Barkın Berk , Murat Duran , İsmail Kayagil , Leyla Yurttaş , Sevde Nur Biltekin Kaleli , Mustafa Yamaç , Ayşe Betül Karaduman and Şeref Demirayak
Published/Copyright: April 27, 2022
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Zeitschrift für Naturforschung C
From the journal Zeitschrift für Naturforschung C Volume 77 Issue 9-10

Abstract

In this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized following a multi-step synthetic procedure. All the compounds were screened with a panel of gram positive/negative bacteria, yeasts, and molds for antimicrobial activity using the disc diffusion method. Then, the minimum inhibitor concentration (MIC) and the minimum bactericidal concentration (MBC) values of active compounds were determined against Micrococcus luteus, Bacillus cereus, Listeria monocytogenes, and Staphylococcus aureus using the broth microdilution technique. These compounds were also screened for their inhibitory activities against S. aureus DNA gyrase by supercoiling assay. Furthermore, the crystal structure of S. aureus DNA gyrase B ATPase was subjected to a docking experiment to identify the possible interactions between the most active ligand and the active site. Lastly, the in silico technique was performed to analyze and predict the drug-likeness, molecular and ADME properties of the synthesized molecules.

Keywords: antimicrobial activity; ATPase; docking; pyridine; thiazole; triazole
Corresponding author: Naime Funda Tay, Department of Chemistry, Faculty of Science and Letters, Eskisehir Osmangazi University, TR 26480 Eskisehir, Turkey, E-mail:

Acknowledgments

The authors gratefully acknowledge the financial support by Eskişehir Osmangazi University.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This study was supported by the Scientific Research Projects Fund of Eskişehir Osmangazi University by the project number: 201119002.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2022-0002).

Received: 2022-01-07
Accepted: 2022-03-28
Published Online: 2022-04-27
Published in Print: 2022-09-27

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/znc-2022-0002
Keywords for this article
antimicrobial activity; ATPase; docking; pyridine; thiazole; triazole

Articles in the same Issue

  1. Frontmatter
  2. Review Article
  3. Combatting persisted and biofilm antimicrobial resistant bacterial by using nanoparticles
  4. Research Articles
  5. Effect of oligosaccharides on the antioxidant, lipid and inflammatory profiles of rats with streptozotocin-induced diabetes mellitus
  6. A new acylated flavone glycoside, in vitro antioxidant and antimicrobial activities from Saudi Diospyros mespiliformis Hochst. ex A. DC (Ebenaceae) leaves
  7. Biogenic synthesis of gold nanoparticles using Artemia urumiana extract and five different thermal accelerated techniques: fabrication and characterization
  8. Insighting the optoelectronic, charge transfer and biological potential of benzo-thiadiazole and its derivatives
  9. Utilizing response surface methodology to evaluate the process parameters of indigenous cucumber fermentation
  10. Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds
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