Halo-phenolic metabolites and their in vitro antioxidant and cytotoxic activities from the Red Sea alga Avrainvillea amadelpha
-
Usama W. Hawas
,
Lamia T. Abou El-Kassem
Abstract
From the green alga Avrainvillea amadelpha, two new naturally halo-benzaldehyde derivatives were isolated by various chromatographic methods along with 10 known metabolites of bromophenols, sulfonoglycolipid, and steroids. Based on the 1D and 2D NMR spectra as well as on MS data, the structures of the new compounds were identified as 5-bromo-2-(3-bromo-4-hydroxybenzyl)-3,4-dihydroxybenzaldehyde named avrainvilleal (1), and 3-iodo-4-hydroxy-benzaldehyde (2). Using SRB assay, both compounds showed mild and weak cytotoxic activity against HeLa and MCF-7 cancer cell lines, compared to the good activity of their extract (IC50 values 3.1 and 4.3 μg/mL, respectively). However, avrainvilleal (1) displayed an effective scavenged DPPH radical activity with IC50 value 3.5 μM, compared to the antioxidant quercetin with IC50 value 1.5 μM.
Funding source: King Abdulaziz University
Acknowledgments
This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah under grant No (G: 659-150-1439). The authors, therefore, acknowledge with thank DSR for technical and financial support.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Conflict of interest statement: The authors declare no conflict of interest relating to the article.
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Supplementary material
The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2020-0221).
The 1D- and 2D-NMR and mass spectra of compound 1-3 are available as Supporting Information.
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume)
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- Book Review
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Artikel in diesem Heft
- Frontmatter
- Research Articles
- Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume)
- Down-regulation of SORL1 is associated with Alzheimer’s disease through activating ABC transporter pathway
- Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey
- Analysis and chemotaxonomic significance of pyrrolizidine alkaloids from two Boraginaceae species growing in Algeria
- Halo-phenolic metabolites and their in vitro antioxidant and cytotoxic activities from the Red Sea alga Avrainvillea amadelpha
- PEPPSI complexes as potential prodrugs: enzyme inhibition, antioxidant activity, electrochemical characterization, molecular docking analysis
- Anti-Leishmania activity of extracts from Piper cabralanum C.DC. (Piperaceae)
- Anticancer Cardenolides from the aerial parts of Calortopis procera
- Cytotoxic withanolides from Datura innoxia
- Book Review
- A. Sigel, E. Freisinger & R. K. O. Sigel (Eds.), M. E. Sosa Torres & P. M. H. Kroneck (volume Eds.): Transition Metals and Sulfur – A Strong Relationship for Life
