Neuroprotective constituents of Actaea acuminata (Wall. ex Royle) H. Hara roots

Deepak Kumar; Suresh Kumar

doi:10.1515/znc-2020-0209

Article

Neuroprotective constituents of Actaea acuminata (Wall. ex Royle) H. Hara roots

Deepak Kumar and Suresh Kumar

Published/Copyright: September 28, 2020

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From the journal Zeitschrift für Naturforschung C Volume 76 Issue 9-10

Abstract

The methanol extract and its ethyl acetate fraction (EAF) of Actaea acuminata (Wall. ex. Royle) H. Hara roots were reported to exhibit significant antianxiety, anticonvulsant and antidepressant activities, and mild sedative activity. But the constituents responsible for these activities have not been isolated. The present study was undertaken to isolate neuroprotective compounds of A. acuminata following bioactivity-guided-fractionation. The column chromatography of EAF and its sub-fractions led to the isolation of four phenolic compounds (bergenin, gallic acid, acetyl bergenin and racemic mixture of diacetyl bergenin), which were characterized by IR and NMR spectral analysis. All the compounds exhibited significant antianxiety and antidepressant activities with respect to control. The gallic acid and bergenin did not show anticonvulsant activity, whereas acetyl bergenin and racemic mixture of diacetyl bergenin exhibited significant anticonvulsant activity. Neuropharmacological activities of A. acuminata are attributed due to polyphenolic compounds. Scientific validation of traditional claims of A. acuminata has opened up roadmap of research for the development of CNS affecting lead molecules.

Keywords: Actaea acuminata ; anxiolytic; anticonvulsant; Himalayan Baneberry; sedative

Corresponding author: Dr. Suresh Kumar, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147 002, Punjab, India, E-mail: thakur_pu@yahoo.com

Funding source: Science and Engineering Board, Department of Science and Technology, Government of India, New Delhi, India

Award Identifier / Grant number: SB/SO/HS-59/2014, dated 05-06-2015

Acknowledgments

The financial assistance provided by Department of Science and Technology, New Delhi to Dr Suresh Kumar for the present research work is duly acknowledged.

Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: Science and Engineering Board, Department of Science and Technology, Government of India, New Delhi, India (SB/SO/HS-59/2014, dated 05-06-2015).
Conflict of interest statement: The authors report no declaration of interest.

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Received: 2020-08-17

Accepted: 2020-09-07

Published Online: 2020-09-28

Published in Print: 2021-09-27

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https://doi.org/10.1515/znc-2020-0209

Keywords for this article

Actaea acuminata; anxiolytic; anticonvulsant; Himalayan Baneberry; sedative