Structural elucidation and neuroprotective activities of lignans from the flower buds of Magnolia biondii Pamp.
-
Qinge Ma
,
Rongrui Wei
,
Xiaodong Zhang
,
Zhipei Sang
Abstract
Two new lignans, 3,4-(10-methoxy-phenylallyl)-9″-((10′-isopropanol-3′,4′-furan)-phenylacetyl)-8″-dioxane-7″-O-β-d-glucopyranoside (1), 3,4-benzolactone-9″-((12′-isopropanol-3′,4′-furan)-phenylbutenone)-8″-dioxane-7″-O-β-d-glucopyranoside (2), and nine known lignan derivatives (3–11) were isolated from the flower buds of Magnolia biondii Pamp. for the first time. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS data, as well as by comparison with those of the references. Compounds (1–11) were evaluated for their neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells. As a result, compounds 1, 2, and 5 exhibited significant neuroprotective activities with IC50 values in the range of 3.08–6.12 μM.
Award Identifier / Grant number: 501100013066
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This work was supported by the Key Scientific Research Project of Colleges and University of Henan Province (19A350006).
Competing interest: The authors declared no potential conflicts of interests with respect to the Research, authorship, and/or publication of this article.
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Articles in the same Issue
- Frontmatter
- Review Article
- A systematic review of botany, phytochemicals and pharmacological properties of “Hoja santa” (Piper auritum Kunth)
- Research Articles
- Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway
- Potential insecticidal activity of aminonaphthoquinone Mannich bases derived from lawsone and their copper (II) complex derivatives
- Design and synthesis of novel n-butyphthalide derivatives as promising botanical fungicides
- Cotinus coggygria Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells
- Elaeocarpus floribundus Bl. seeds as a new source of bioactive compounds with promising antioxidant and antimicrobial properties
- Structural elucidation and neuroprotective activities of lignans from the flower buds of Magnolia biondii Pamp.
- Distillation time effecting on the composition of Origanum floribundum essential oils and their antioxidant and antimicrobial activities
- Root essential oil of Chrysopogon zizanioides relaxes rat isolated thoracic aorta – an ex vivo approach
- Synergistic antibacterial combination of Lavandula latifolia Medik. essential oil with camphor
