Antiproliferative activity of synthesized some new benzimidazole carboxamidines against MCF-7 breast carcinoma cells
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Cigdem Karaaslan
Abstract
Breast cancer is the most endemic cause of cancer among women in both developed and developing countries. Benzimidazole derivatives exemplify one of the chemical classes that show strong cytotoxic activity especially against breast cancer cells (MCF-7). Aromatic amidine derivatives are known as a group of DNA interactive compounds that bind minor groove of the genome, especially A-T base pairs, and show significant in vitro and in vivo toxicity toward cancer cells. In light of these studies, some new mono/dicationic amidino benzimidazole derivatives were synthesized and evaluated for cytotoxic activity on cultured MCF-7 breast cancer cells. Some of these compounds have strongly inhibited MCF-7 cell viability in a dose-dependent manner compared with clinically used reference compounds, imatinib mesylate and docetaxel. Among them, 4-[(5(6)-bromo-1H-benzimidazole-2-yl)amino]benzene-1-carboxamidine (30) showed the best inhibitory activity with IC50 value of 4.6 nM.
Acknowledgments
The Central Laboratory of Pharmacy Faculty of Ankara University provided support for acquisition of the NMR, mass spectrometer, and elemental analyzer used in this work.
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Supplemental Material:
The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2017-0067).
©2018 Walter de Gruyter GmbH, Berlin/Boston
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- Frontmatter
- Fast RBC loading by fluorescent antibodies and nuclei staining dye and their potential bioanalytical applications
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- Design, synthesis, and antibacterial activity of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety
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- Overexpression of c-Myc enhances recombinant protein production in High Five cells after baculovirus infection
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