Acute toxicity, antiedematogenic activity, and chemical constituents of Palicourea rigida Kunth
-
Vanessa G. Alves
Abstract
The phytochemical study of the leaves, roots, and flowers of Palicourea rigida led to the isolation of the triterpenes betulinic acid (1) and lupeol (2), the diterpene phytol (3), and the iridoid glycosides sweroside (4) and secoxyloganin (5). These compounds were identified using NMR 1H and 13C and comparing the spectra with published data. We studied the antiedematogenic activity of crude extracts from the organs, and of different fractions, in mice and found that the n-hexane fraction of the leaf extract significantly inhibited the ear edema resulting from croton oil administration. The crude extract from leaves was not acutely toxic to the mice.
Acknowledgments
The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação Araucária for financial support. The authors thank Dr. Elekofehinti Olusola Olalekan for proof-reading the manuscript.
References
1. Bolzani VS, Trevisan LM, Young MC. Triterpenes of Palicourea rigida H. B. K. Revista Latinoamericana de Química 1992;23:20–1.Search in Google Scholar
2. Vencato I, Silva FM, Oliveira CM, Kato L, Tanaka CM, Silva CC, et al. Vallesiachotamine. Acta Crystallography E 2006;62:429–30.10.1107/S1600536805041553Search in Google Scholar
3. Corrêa MP. Dicionário das plantas úteis do Brasil e das exóticas cultivadas. Rio de Janeiro: Imprensa Nacional, 1984.Search in Google Scholar
4. Lopes S, Poser GL, Kerber VA, Farias FM, Konrath EL, Moreno P, et al. Taxonomic significance of alkaloids and iridoid glucosides in the tribe Psychotrieae (Rubiaceae). Biochem Syst Ecol 2004;32:1187–95.10.1016/j.bse.2004.04.015Search in Google Scholar
5. Morel LJ, Baratto DM, Pereira PS, Contini SH, Momm HG, Bertoni BW, et al. Loganin production in Palicourea rigida H.B.K. (Rubiaceae) from populations native to Brazilian Cerrado. Journal of Medicinal Plants Research 2011;5:2559–65.Search in Google Scholar
6. Rosa EA, Silva BC, Silva FM, Tanaka CM, Peralta RM, Oliveira CM, et al. Flavonóides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae. Revista Brasileira de Farmacognosia 2010;20:484–8.10.1590/S0102-695X2010000400004Search in Google Scholar
7. Takeda Y, Masuda T, Honda G, Takaishi Y, Ito M, Ashurmetov O, et al. An iridoid glucoside dimer and non-glycoside iridoid from the leaves of Lasianthus wallichii. Chem Pharm Bull 1999;47:1338–40.10.1248/cpb.47.1338Search in Google Scholar
8. Prasad D, Juyal V, Singh R, Singh V, Pant G, Rawat MS. A new secoiridoid from Lonicera angustifolia. Fitoterapia 2000;71: 420–4.10.1016/S0367-326X(00)00149-0Search in Google Scholar
9. Boros CA, Stermitz FR. Iridoids. An update review. J Nat Prod 1991;54:1173–246.10.1021/np50077a001Search in Google Scholar
10. Mahato SB, Kundu AP. 13C NMR spectra of pentacyclic triterpenoids – a compilation and some salient features. Phytochemistry 1994;37:1517–75.10.1016/S0031-9422(00)89569-2Search in Google Scholar
11. Melos JL, Silva LB, Peres MT, Mapeli AM, Faccenda O, Anjos HH, et al. Constituíntes químicos e avaliação do potencial alelopático de Adiantum tetraphyllum HUMB. & BONPL. EX. WILLD (Pteridaceae). Química Nova 2007;30:292–7.10.1590/S0100-40422007000200010Search in Google Scholar
12. Shimizu M, Tomoo T. Anti-inflamatory constituents of topically applied crude drugs. Biol Pharm Bull 1994;17:665–7.10.1248/bpb.17.665Search in Google Scholar PubMed
13. Yogeeswari P, Sriram D. Betulinic acid and its derivatives: a review on their biological properties. Curr Med Chem 2005;12:657–66.10.2174/0929867053202214Search in Google Scholar PubMed
14. Kwak WJ, Cho YB, Han CK, Shin HJ, Ryu KH, Yoo H, et al. Extraction and purification method of active constituents from stem of Lonicera japonica Thunb., its usage for anti-inflammatory and analgesic drug. 2007, US2007/0111955A1.Search in Google Scholar
15. Van Harman GC. Anti-inflammatory drugs. Clin Pharmacol Ther 1974;16:900–4.10.1002/cpt1974165part2900Search in Google Scholar PubMed
16. Malone MH, Robichaud RC. Hippocratic screen for pure or crude drug materials. Lloydia 1962;25:320–32.Search in Google Scholar
©2016 by De Gruyter
Articles in the same Issue
- Frontmatter
- Acute toxicity, antiedematogenic activity, and chemical constituents of Palicourea rigida Kunth
- Fatty acid composition of achenes of Cirsium taxa (Asteraceae, Carduoideae) from Turkey
- Characterization of the cardiac glycoside and lipid profiles of Strophanthus kombé Oliv. seeds
- Thonningiiflavanonol A and thonningiiflavanonol B, two novel flavonoids, and other constituents of Ficus thonningii Blume (Moraceae)
- Some rape/canola seed oils: fatty acid composition and tocopherols
- The physico-chemical properties of some citrus seeds and seed oils
- Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines
Articles in the same Issue
- Frontmatter
- Acute toxicity, antiedematogenic activity, and chemical constituents of Palicourea rigida Kunth
- Fatty acid composition of achenes of Cirsium taxa (Asteraceae, Carduoideae) from Turkey
- Characterization of the cardiac glycoside and lipid profiles of Strophanthus kombé Oliv. seeds
- Thonningiiflavanonol A and thonningiiflavanonol B, two novel flavonoids, and other constituents of Ficus thonningii Blume (Moraceae)
- Some rape/canola seed oils: fatty acid composition and tocopherols
- The physico-chemical properties of some citrus seeds and seed oils
- Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines
