Synthesis and biological evaluation of chalcone-triazole hybrid derivatives as 15-LOX inhibitors
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Ali Asadipour
Abstract
An efficient aldol condensation/click reaction sequence is employed for the synthesis of chalcone-triazole-based derivatives in moderate to good yields. The ability of target compounds to inhibit 15-lipoxygenase enzyme was investigated and moderate to low inhibitory activities were observed for the synthesized compounds.
Acknowledgments
This study was funded and supported by Tehran University of Medical Sciences (TUMS); Grant no. 96-02-33-35087; and Iran National Science Foundation (INSF).
References
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Supplemental Material:
The online version of this article offers supplementary material (https://doi.org/10.1515/znb-2017-0115).
©2018 Walter de Gruyter GmbH, Berlin/Boston
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- Frontmatter
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Articles in the same Issue
- Frontmatter
- In this Issue
- Synthesis and biological evaluation of chalcone-triazole hybrid derivatives as 15-LOX inhibitors
- Synthesis, crystal structure, and photoluminescence of a lithium isothiocyanate compound with 18-crown-6
- Synthesis of madecassic acid derivatives and their cytotoxic activity
- Charge density studies on methylene blue – a potential anti-Alzheimer agent
- Fused thia-heterocycles via isothiocyanates. Part II. A convenient synthesis of some new thieno[2,3-b]thiopyran-4-one derivatives
- Cd(II) and Zn(II) thiocyanate coordination compounds with 3-ethylpyridine: synthesis, crystal structures and properties
- Aminkomplexe des Goldes, Teil 10: Gold(I)-thiocyanat-Komplexe mit Tetrahydrothiophen, Dimethylsulfid, Ammoniak, Aminen und Azaaromatena