Startseite Mathematik Personalization of parameters of electro-physiological model of the human heart
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Personalization of parameters of electro-physiological model of the human heart

  • Vasilii Yu. Kabak EMAIL logo , Roman O. Rokeakh , Tatyana M. Nesterova , Maksim A. Dzhigil , Tatyana V. Chumarnaya , Arsenii D. Dokuchaev und Olga E. Solovyova
Veröffentlicht/Copyright: 6. November 2025

Abstract

Mathematical modelling in personalized medicine requires the identification of model parameters characterizing the clinical picture. Simplification and acceleration of this process will make it possible to implement modelling in routine clinical practice with greater efficiency. We have conducted a study of the dependencies between identified parameter (myocardial conductivity) and the activation time of 95% of the myocardium or the width of the QRS complex within a collection of personalized models of ventricles of patients with chronic heart failure and left bundle branch block, as well as varying degrees of structural and functional damage to the myocardium. A simplified algorithm for determining individual myocardial conductivity based on clinical features of a patient’s electrocardiogram using regression models has been proposed. The results show high accuracy in predicting QRSd values using the proposed algorithm, which demonstrates the possibility to facilitate significantly the personalization of model parameters for their wide application.

MSC 2010: 92C50; 65K10; 62J05; 62P10

Funding statement: The work was supported by the Russian Science Foundation, project No. 24–15–00335.

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Received: 2025-03-01
Revised: 2025-04-10
Accepted: 2025-08-26
Published Online: 2025-11-06
Published in Print: 2025-11-25

© 2025 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 15.1.2026 von https://www.degruyterbrill.com/document/doi/10.1515/rnam-2025-0026/html?lang=de
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