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The physiopathology of spontaneous hemorrhagic stroke: a systematic review

  • Alcivan Batista de Morais Filho EMAIL logo , Thiago Luis de Holanda Rego , Letícia de Lima Mendonça , Sulyanne Saraiva de Almeida , Mariana Lima da Nóbrega , Thais de Oliveira Palmieri , Gabriela Zanotto Della Giustina , Jáderson Pimenta Melo , Francisco Irochima Pinheiro and Fausto Pierdoná Guzen
Published/Copyright: February 17, 2021
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Abstract

Hemorrhagic stroke (HS) is a major cause of death and disability worldwide, despite being less common, it presents more aggressively and leads to more severe sequelae than ischemic stroke. There are two types of HS: Intracerebral Hemorrhage (ICH) and Subarachnoid Hemorrhage (SAH), differing not only in the site of bleeding, but also in the mechanisms responsible for acute and subacute symptoms. This is a systematic review of databases in search of works of the last five years relating to the comprehension of both kinds of HS. Sixty two articles composed the direct findings of the recent literature and were further characterized to construct the pathophysiology in the order of events. The road to the understanding of the spontaneous HS pathophysiology is far from complete. Our findings show specific and individual results relating to the natural history of the disease of ICH and SAH, presenting common and different risk factors, distinct and similar clinical manifestations at onset or later days to weeks, and possible complications for both.


Corresponding author: Alcivan Batista de Morais Filho, Rua Miguel Antônio da Silva Neto, 98, Aeroporto I, Mossoró, RN, 59607-360, Brazil; and Universidade do Estado do Rio Grande do Norte, Mossoró, Brazil, E-mail:

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2020-11-11
Accepted: 2021-01-22
Published Online: 2021-02-17
Published in Print: 2021-08-26

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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