Resveratrol in the treatment of neuroblastoma: a review
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Kamil Leis
,
Weronika Bereźnicka
Abstract
Resveratrol, polyphenol naturally occurring in grapes or nuts, has anti-cancer properties in the treatment of neuroblastoma – the most common childhood solid tumor. It affects cancer cells by increasing apoptosis, inducing cell necrosis and reducing tumor mass. Mechanism of action – (1) converting procaspases, mainly procaspases three and nine into active forms – caspases, (2) blocking kinases, and also (3) leading the cell to the S-cell cycle, where it is most effective while increasing the concentration of cyclin E and lowering the concentration of p21 protein. In vitro, as well as, rodent animal models studies are available and show promising results. Therapeutic doses, currently within 10–100 μmol/L, are also being tested, as well as other forms of resveratrol, such as its trans-4,4′-dihydroxystilbene analog and polyphenol lipoconjugates. In our review, we presented the known molecular mechanisms of polyphenol anti-tumor activity against neuroblastoma and discussed the studies confirming its effectiveness.
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- A bigger brain for a more complex environment
- Lifestyle intervention to prevent Alzheimer’s disease
- Machine learning (ML) for the diagnosis of autism spectrum disorder (ASD) using brain imaging
- Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review
- Resveratrol in the treatment of neuroblastoma: a review
- Retinal involvement in Alzheimer's disease (AD): evidence and current progress on the non-invasive diagnosis and monitoring of AD-related pathology using the eye
- Noninvasive brain stimulation for patients with a disorder of consciousness: a systematic review and meta-analysis
Artikel in diesem Heft
- Frontmatter
- A bigger brain for a more complex environment
- Lifestyle intervention to prevent Alzheimer’s disease
- Machine learning (ML) for the diagnosis of autism spectrum disorder (ASD) using brain imaging
- Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review
- Resveratrol in the treatment of neuroblastoma: a review
- Retinal involvement in Alzheimer's disease (AD): evidence and current progress on the non-invasive diagnosis and monitoring of AD-related pathology using the eye
- Noninvasive brain stimulation for patients with a disorder of consciousness: a systematic review and meta-analysis
