Cochlear synaptopathy: new findings in animal and human research
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Cristian Aedo
Abstract
In animal models, prolonged exposure (2 h) to high-level noise causes an irreparable damage to the synapses between the inner hair cells and auditory nerve fibers within the cochlea. Nevertheless, this injury does not necessarily alter the hearing threshold. Similar findings have been observed as part of typical aging in animals. This type of cochlear synaptopathy, popularly called “hidden hearing loss,” has been a significant issue in neuroscience research and clinical audiology scientists. The results obtained in different investigations are inconclusive in their diagnosis and suggest new strategies for both prognosis and treatment of cochlear synaptopathy. Here we review the major physiological findings regarding cochlear synaptopathy in animals and humans and discuss mathematical models. We also analyze the potential impact of these results on clinical practice and therapeutic options.
Funding source: Universidad de Chile
Award Identifier / Grant number: U-inicia 10/16
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.CA and EA wrote the paper; EA interacted with reviewers.
Research funding: Work supported by a grant of the University of Chile (UI-10/16) to EA.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat
- Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease
- Cochlear synaptopathy: new findings in animal and human research
- Neurophysiologic implications of neuronal nitric oxide synthase
- Exploring the mechanisms of action of the antidepressant effect of the ketogenic diet
- The potential anti-depressant properties of dexmedetomidine infusion: a review of mechanistic, preclinical, and clinical evidence
- Role of kinaesthetic motor imagery in mirror-induced visual illusion as intervention in post-stroke rehabilitation
- A review on the alterations in the brain of persistent postural-perceptual dizziness patients and non-pharmacological interventions for its management
- A new method to predict anomaly in brain network based on graph deep learning
Artikel in diesem Heft
- Frontmatter
- GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat
- Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease
- Cochlear synaptopathy: new findings in animal and human research
- Neurophysiologic implications of neuronal nitric oxide synthase
- Exploring the mechanisms of action of the antidepressant effect of the ketogenic diet
- The potential anti-depressant properties of dexmedetomidine infusion: a review of mechanistic, preclinical, and clinical evidence
- Role of kinaesthetic motor imagery in mirror-induced visual illusion as intervention in post-stroke rehabilitation
- A review on the alterations in the brain of persistent postural-perceptual dizziness patients and non-pharmacological interventions for its management
- A new method to predict anomaly in brain network based on graph deep learning
