Startseite Lebenswissenschaften Retinal involvement in Alzheimer's disease (AD): evidence and current progress on the non-invasive diagnosis and monitoring of AD-related pathology using the eye
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Retinal involvement in Alzheimer's disease (AD): evidence and current progress on the non-invasive diagnosis and monitoring of AD-related pathology using the eye

  • Fidelis Chibhabha ORCID logo , Yang Yaqi und Feng Li EMAIL logo
Veröffentlicht/Copyright: 17. August 2020

Abstract

Alzheimer's disease (AD) is a common form of age-related dementia that mostly affects the aging population. Clinically, it is a disease characterized by impaired memory and progressive cognitive decline. Although the pathological hallmarks of AD have been traditionally described with a general confinement in the brain, recent studies have shown similar pathological changes in the retina, which is a developmental outgrowth of the forebrain. These AD-related neurodegenerative changes in the retina have been implicated to cause early visual problems in AD even before cognitive impairment becomes apparent. With recent advances in research, the commonly held view that AD-related cerebral pathology causes visual dysfunction through disruption of central visual pathways has been re-examined. Currently, several studies have already explored how AD manifests in the retina and the possibility of using the same retina as a window to non-invasively examine AD-related pathology in the brain. Non-invasive screening of AD through the retina has the potential to improve on early detection and management of the disease since the majority of AD cases are usually diagnosed very late. The purpose of this review is to provide evidence on the involvement of the retina in AD and to suggest a possible direction for future research into the non-invasive screening, diagnosis, and monitoring of AD using the retina.


Corresponding author: Feng Li, Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; and Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China, E-mail:

Award Identifier / Grant number: 81271476

Funding source: Guangzhou Science and Technology Plan Research Project

Award Identifier / Grant number: 201300000154

Funding source: Guangdong Natural Science Foundation

Award Identifier / Grant number: 2014A030310104

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The authors deeply appreciate the financial support provided from the following grants: the National Science Foundation of China Grant (81271476), Guangzhou Science and Technology Plan Research Project Grant (201300000154), and the Guangdong Natural Science Foundation Grant (2014A030310104).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2019-12-23
Accepted: 2020-06-04
Published Online: 2020-08-17
Published in Print: 2020-11-18

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 22.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/revneuro-2019-0119/html?lang=de
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