The role of melatonin and its analogues in epilepsy

References

Acuna Castroviejo, D., Castillo, J.L., Fernandez, B., Gomar, M.D., and del Aguila, C.M. (1992). Modulation by pineal gland of ouabain high-affinity binding sites in rat cerebral cortex. Am. J. Physiol. Regul. Integr. Comp. Physiol. 262: R698–R706, https://doi.org/10.1152/ajpregu.1992.262.4.r698.Suche in Google Scholar

Acuna-Castroviejo, D., Lowenstein, P.R., Rosenstein, R., and Cardinali, D.P. (1986). Diurnal variations of benzodiazepine binding in rat cerebral cortex: disruption by pinealectomy. J. Pineal Res. 3: 101–109, https://doi.org/10.1111/j.1600-079x.1986.tb00732.x.Suche in Google Scholar

Aguiar, C.C.T., Almeida, A.B., Araújo, P.V.P., Vasconcelos, G.S., Chaves, E.M.C., do Vale, O.C., Macêdo, D.S., de Sousa, F.C.F., de Barros Viana, G.S., and Vasconcelos, S.M.M. (2012). Anticonvulsant effects of agomelatine in mice. Epilepsy Behav. 24: 324–328, https://doi.org/10.1016/j.yebeh.2012.04.134.Suche in Google Scholar

Aguiar, C.C.T., Almeida, A.B., Araújo, P.V.P., Vasconcelos, G.S., Chaves, E.M.C., do Vale, O.C., Macêdo, D.S., Leal, L.K.A.M., de Barros Viana, G.S., and Vasconcelos, S.M.M. (2013). Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cell. Mol. Neurobiol. 33: 825–835, https://doi.org/10.1007/s10571-013-9949-0.Suche in Google Scholar

Akaike, H., Kondo, E., Kono, M., and Kato, A. (2016). Hypnotic effects of ramelteon during electroencephalography. No to hattatsu. Brain Dev. 48: 10–13.Suche in Google Scholar

Allagui, M., Feriani, A., Saoudi, M., Badraoui, R., Bouoni, Z., Nciri, R., Murat, J., and Elfeki, A. (2014). Effects of melatonin on aluminium-induced neurobehavioral and neurochemical changes in aging rats. Food Chem. Toxicol. 70: 84–93, https://doi.org/10.1016/j.fct.2014.03.043.Suche in Google Scholar

Arendt, J. (2005). Melatonin: characteristics, concerns, and prospects. J. Biol. Rhythm. 20: 291–303, https://doi.org/10.1177/0748730405277492.Suche in Google Scholar

Audinot, V., Mailliet, F., Lahaye-Brasseur, C., Bonnaud, A., Le Gall, A., Amossé, C., Dromaint, S., Rodriguez, M., Nagel, N., and Galizzi, J.-P. (2003). New selective ligands of human cloned melatonin MT 1 and MT 2 receptors. N. Schmied. Arch. Pharmacol. 367: 553–561, https://doi.org/10.1007/s00210-003-0751-2.Suche in Google Scholar

Aydin, L., Gundogan, N.U., and Yazici, C. (2015). Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures. Epilepsy Res. 118: 49–54, https://doi.org/10.1016/j.eplepsyres.2015.11.004.Suche in Google Scholar

Aygün, H., Aydin, D., Inanir, S., Ekici, F., Ayyildiz, M., and Ağar, E. (2015). The effects of agomelatine and melatonin on ECoG activity of absenceepilepsy model in WAG/Rij rats. Turkish J. Biol. 39: 904–910, https://doi.org/10.3906/biy-1507-32.Suche in Google Scholar

Azim, M.S., Agarwal, N.B., and Vohora, D. (2017). Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine. Epilepsy Behav. 72: 140–144, https://doi.org/10.1016/j.yebeh.2017.03.019.Suche in Google Scholar

Banach, M., Gurdziel, E., Jędrych, M., and Borowicz, K.K. (2011). Melatonin in experimental seizures and epilepsy. Pharmacol. Rep. 63: 1–11, https://doi.org/10.1016/s1734-1140(11)70393-0.Suche in Google Scholar

Banerjee, S., and Kumar, V. (2013). Question 1: in a child with epilepsy, does melatonin affect the seizure threshold?. Arch. Dis. Child. 98: 642–644, https://doi.org/10.1136/archdischild-2013-304036.Suche in Google Scholar

Barghout, M.S., Darwish, A.H., El Amrousy, D.M., and Al-shahawy, A.K. (2019). Comparison between efficacy of melatonin and diazepam for prevention of recurrent simple febrile seizures: a randomized clinical trial. Pediatr.10.1016/j.pediatrneurol.2019.01.010Suche in Google Scholar

Bauer, B.A. (2017). Is melatonin a helpful sleep aid — and what should I know about melatonin side effects?.Suche in Google Scholar

Bavithra, S., Priya, E.S., Selvakumar, K., Krishnamoorthy, G., and Arunakaran, J. (2015). Effect of melatonin on glutamate: BDNF signaling in the cerebral cortex of polychlorinated biphenyls (PCBs)—exposed adult male rats. Neurochem. Res. 40: 1858–1869, https://doi.org/10.1007/s11064-015-1677-z.Suche in Google Scholar

Bazil, C.W., Short, D., Crispin, D., and Zheng, W. (2000). Patients with intractable epilepsy have low melatonin, which increases following seizures. Neurology 55: 1746–1748, https://doi.org/10.1212/wnl.55.11.1746.Suche in Google Scholar

Bertaina-Anglade, V., Drieu-La-Rochelle, C., Mocaër, E., and Seguin, L. (2011). Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat. Pharmacol. Biochem. Behav. 98: 511–517, https://doi.org/10.1016/j.pbb.2011.02.015.Suche in Google Scholar

Bikjdaouene, L., Escames, G., Leon, J., Ferrer, J.M., Khaldy, H., Vives, F., and Acuña‐Castroviejo, D. (2003). Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole‐induced seizures. J. Pineal Res. 35: 54–60, https://doi.org/10.1034/j.1600-079x.2003.00055.x.Suche in Google Scholar

Borowicz, K.K., Kamiński, R., Gasior, M., Kleinrok, Z., and Czuczwar, S.J. (1999). Influence of melatonin upon the protective action of conventional anti-epileptic drugs against maximal electroshock in mice. Eur. Neuropsychopharmacol 9: 185–190, https://doi.org/10.1016/s0924-977x(98)00022-4.Suche in Google Scholar

Bozzi, Y., and Borrelli, E. (2006). Dopamine in neurotoxicity and neuroprotection: what do D2 receptors have to do with it?. Trends Neurosci. 29: 167–174, https://doi.org/10.1016/j.tins.2006.01.002.Suche in Google Scholar

Brigo, F., and Igwe, S.C. (2016). Melatonin as add-on treatment for epilepsy. Cochrane Database Syst. Rev. 3: Cd006967, https://doi.org/10.1002/14651858.cd006967.pub4.Suche in Google Scholar

Buendia, I., Gómez-Rangel, V., González-Lafuente, L., Parada, E., León, R., Gameiro, I., Michalska, P., Laudon, M., Egea, J., and López, M.G. (2015). Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models. Neuropharmacology 99: 187–195, https://doi.org/10.1016/j.neuropharm.2015.07.014.Suche in Google Scholar

Bustamante-García, R., Naranjo-Rodríguez, E.B., Lira-Rocha, A.S., Ortiz-Osornio, A., and Picazo, O. (2013). Behavioural actions of two new 1-N substituted analogues of melatonin. Behav. Brain Res. 236: 148–156, https://doi.org/10.1016/j.bbr.2012.08.045.Suche in Google Scholar

Castillo Romero, J.L., Vives Montero, F., and Acuna Castroviejo, D. (1992). Paradoxical effects of melatonin on spontaneous neuronal activity in the striatum of sham-operated and pinealectomized rats. J. Pineal Res. 12: 149–154, https://doi.org/10.1111/j.1600-079x.1992.tb00042.x.Suche in Google Scholar

Cesarini, E., Cerioni, L., Canonico, B., Di Sario, G., Guidarelli, A., Lattanzi, D., Savelli, D., Guescini, M., Nasoni, M.G., and Bigini, N. (2018). Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria. PloS One 13: e0203001, https://doi.org/10.1371/journal.pone.0203001.Suche in Google Scholar

Chen, S.-D., Chang, A.Y., and Chuang, Y.-C. (2010). The potential role of mitochondrial dysfunction in seizure-associated cell death in the hippocampus and epileptogenesis. J. Bioenerg. Biomembr. 42: 461–465, https://doi.org/10.1007/s10863-010-9321-8.Suche in Google Scholar

Chumboatong, W., Thummayot, S., Govitrapong, P., Tocharus, C., Jittiwat, J., and Tocharus, J. (2017). Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat. Neurochem. Int. 102: 114–122, https://doi.org/10.1016/j.neuint.2016.12.011.Suche in Google Scholar

Conboy, L., Tanrikut, C., Zoladz, P.R., Campbell, A.M., Park, C.R., Gabriel, C., Mocaer, E., Sandi, C., and Diamond, D.M. (2009). The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats. Int. J. Neuropsychopharmacol. 12: 329–341, https://doi.org/10.1017/s1461145708009255.Suche in Google Scholar

Coppola, G., Iervolino, G., Mastrosimone, M., La Torre, G., Ruiu, F., and Pascotto, A. (2004). Melatonin in wake–sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. Brain Dev. 26: 373–376, https://doi.org/10.1016/j.braindev.2003.09.008.Suche in Google Scholar

Corradi, F., Brusasco, C., Paparo, F., Manca, T., Santori, G., Benassi, F., Molardi, A., Gallingani, A., Ramelli, A., Gherli, T., and Vezzani, A. (2015). Renal Doppler resistive index as a marker of oxygen supply and demand mismatch in postoperative cardiac surgery patients. BioMed Res. Int. 2015: 763940, https://doi.org/10.1155/2015/763940.Suche in Google Scholar

Costa-Lotufo, L.V., Fonteles, M.M., Lima, I.S., de Oliveira, A.A., Nascimento, V.S., de Bruin, V.M., and Viana, G.S. (2002). Attenuating effects of melatonin on pilocarpine-induced seizures in rats. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 131: 521–529, https://doi.org/10.1016/s1532-0456(02)00037-6.Suche in Google Scholar

Dabak, O., Altun, D., Arslan, M., Yaman, H., Vurucu, S., Yesilkaya, E., and Unay, B. (2016). Evaluation of plasma melatonin levels in children with afebrile and febrile seizures. Pediatr. Neurol. 57: 51–55, https://doi.org/10.1016/j.pediatrneurol.2015.12.025.Suche in Google Scholar

Dastgheib, M., and Moezi, L. (2014). Acute and chronic effects of agomelatine on intravenous penthylenetetrazol-induced seizure in mice and the probable role of nitric oxide. Eur. J. Pharmacol. 736: 10–15, https://doi.org/10.1016/j.ejphar.2014.04.039.Suche in Google Scholar

de Alencar Rocha, A.K.A., de Lima, E., Amaral, F., Peres, R., Cipolla-Neto, J., and Amado, D. (2017). Altered MT1 and MT2 melatonin receptors expression in the hippocampus of pilocarpine-induced epileptic rats. Epilepsy Behav. 71: 23–34, https://doi.org/10.1016/j.yebeh.2017.01.020.Suche in Google Scholar

de Almeida-Paula, L.D., Costa-Lotufo, L.V., Ferreira, Z.S., Monteiro, A.E.G., Isoldi, M.C., Godinho, R.O., and Markus, R.P. (2005). Melatonin modulates rat myotube-acetylcholine receptors by inhibiting calmodulin. Eur. J. Pharmacol. 525: 24–31, https://doi.org/10.1016/j.ejphar.2005.09.056.Suche in Google Scholar

de la Aleja, J.G., Saiz-Díaz, R.A., and De la Peña, P. (2012). Relief of intractable posthypoxic myoclonus after administration of agomelatine. Clin. Neuropharmacol. 35: 258–259, https://doi.org/10.1097/wnf.0b013e3182613e06.Suche in Google Scholar

de Lima, E., Soares, J.M.Jr., del Carmen Sanabria Garrido, Y., Gomes Valente, S., Priel, M.R., Chada Baracat, E., Abrao Cavalheiro, E., da Graca Naffah-Mazzacoratti, M., and Amado, D. (2005). Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats. Brain Res. 1043: 24–31, https://doi.org/10.1016/j.brainres.2005.02.027.Suche in Google Scholar

Elkhayat, H.A., Hassanein, S.M., Tomoum, H.Y., Abd-Elhamid, I.A., Asaad, T., and Elwakkad, A.S. (2010). Melatonin and sleep-related problems in children with intractable epilepsy. Pediatr. Neurol. 42: 249–254, https://doi.org/10.1016/j.pediatrneurol.2009.11.002.Suche in Google Scholar

Ethemoglu, M., Kutlu, S., Seker, F., Erdogan, C., Bingol, C., and Yilmaz, B. (2018). Effects of agomelatine on electrocorticogram activity on pencillin-induced epilepsy model of rats. Neurosciv, https://doi.org/10.1016/j.neulet.2018.09.014.Suche in Google Scholar

Fauteck, J., Schmidt, H., Lerchl, A., Kurlemann, G., and Wittkowski, W. (1999). Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol. Signals Recept. 8: 105–110, https://doi.org/10.1159/000014577.Suche in Google Scholar

Fenoglio-Simeone, K., Mazarati, A., Sefidvash-Hockley, S., Shin, D., Wilke, J., Milligan, H., Sankar, R., Rho, J.M., and Maganti, R. (2009). Anticonvulsant effects of the selective melatonin receptor agonist ramelteon. Epilepsy Behav. 16: 52–57, https://doi.org/10.1016/j.yebeh.2009.07.022.Suche in Google Scholar

Fisher, R.S., Acevedo, C., Arzimanoglou, A., Bogacz, A., Cross, J.H., Elger, C.E., Engel, J.Jr, Forsgren, L., French, J.A., and Glynn, M. (2014). ILAE official report: a practical clinical definition of epilepsy. Epilepsia 55: 475–482, https://doi.org/10.1111/epi.12550.Suche in Google Scholar

Fisher, S.P., Davidson, K., Kulla, A., and Sugden, D. (2008). Acute sleep‐promoting action of the melatonin agonist, ramelteon, in the rat. J. Pineal Res. 45: 125–132, https://doi.org/10.1111/j.1600-079x.2008.00565.x.Suche in Google Scholar

Galano, A., Castañeda-Arriaga, R., Pérez-González, A., Tan, D.-X., and Reiter, R. (2016). Phenolic melatonin-related compounds: their role as chemical protectors against oxidative stress. Molecules 21: 1442, https://doi.org/10.3390/molecules21111442.Suche in Google Scholar

Galano, A., Tan, D.-X., and Reiter, R. (2018). Melatonin: a versatile protector against oxidative DNA damage. Molecules 23: 530, https://doi.org/10.3390/molecules23030530.Suche in Google Scholar

García, T., Ribes, D., Colomina, M.T., Cabré, M., Domingo, J.L., and Gómez, M. (2009). Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer’s disease. Toxicology 265: 49–55, https://doi.org/10.1016/j.tox.2009.09.009.Suche in Google Scholar

Gerdin, M.J., Masana, M.I., Rivera-Bermúdez, M.A., Hudson, R.L., Earnest, D.J., Gillette, M.U., and Dubocovich, M.L. (2004). Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin. Faseb. J. 18: 1646–1656, https://doi.org/10.1096/fj.03-1339com.Suche in Google Scholar

Goldberg-Stern, H., Oren, H., Peled, N., and Garty, B.Z. (2012). Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. J. Child Neurol. 27: 1524–1528, https://doi.org/10.1177/0883073811435916.Suche in Google Scholar

Gressens, P., Schwendimann, L., Husson, I., Sarkozy, G., Mocaer, E., Vamecq, J., and Spedding, M. (2008). Agomelatine, a melatonin receptor agonist with 5-HT2C receptor antagonist properties, protects the developing murine white matter against excitotoxicity. Eur. J. Pharmacol. 588: 58–63, https://doi.org/10.1016/j.ejphar.2008.04.016.Suche in Google Scholar

Gross, P.K., Nourse, R., and Wasser, T.E. (2009). Ramelteon for insomnia symptoms in a community sample of adults with generalized anxiety disorder: an open label study. J Clini Sleep Med 5: 28–33, https://doi.org/10.5664/jcsm.27389.Suche in Google Scholar

Gupta, Y.K., Gupta, M., Chaudhary, G., and Kohli, K. (2004). Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice. Methods Find. Exp. Clin. Pharmacol. 26: 99–102, https://doi.org/10.1358/mf.2004.26.2.800061.Suche in Google Scholar

He, P., Ouyang, X., Zhou, S., Yin, W., Tang, C., Laudon, M., and Tian, S. (2013). A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer’disease. Horm. Behav. 64: 1–7, https://doi.org/10.1016/j.yhbeh.2013.04.009.Suche in Google Scholar

Herrera, F., Martin, V., García‐Santos, G., Rodriguez‐Blanco, J., Antolín, I., and Rodriguez, C. (2007). Melatonin prevents glutamate‐induced oxytosis in the HT22 mouse hippocampal cell line through an antioxidant effect specifically targeting mitochondria. J. Neurochem. 100: 736–746, https://doi.org/10.1111/j.1471-4159.2006.04228.x.Suche in Google Scholar

Jain, S., and Besag, F.M. (2013). Does melatonin affect epileptic seizures?. Drug Saf. 36: 207–215, https://doi.org/10.1007/s40264-013-0033-y.Suche in Google Scholar

Jain, S.V., Horn, P.S., Simakajornboon, N., Beebe, D.W., Holland, K., Byars, A.W., and Glauser, T.A. (2015). Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study. Sleep Med. 16: 637–644, https://doi.org/10.1016/j.sleep.2015.01.005.Suche in Google Scholar

Jan, J.E., Connolly, M.B., Hamilton, D., Freeman, R.D., and Laudon, M. (1999). Melatonin treatment of non-epileptic myoclonus in children. Dev. Med. Child Neurol. 41: 255–259, https://doi.org/10.1017/s0012162299000535.Suche in Google Scholar

Jarrett, S.G., Liang, L.-P., Hellier, J.L., Staley, K.J., and Patel, M. (2008). Mitochondrial DNA damage and impaired base excision repair during epileptogenesis. Neurobiol. Dis. 30: 130–138, https://doi.org/10.1016/j.nbd.2007.12.009.Suche in Google Scholar

Kabuto, H., Yokoi, I., and Ogawa, N. (1998). Melatonin inhibits iron‐induced epileptic discharges in rats by suppressing peroxidation. Epilepsia 39: 237–243, https://doi.org/10.1111/j.1528-1157.1998.tb01367.x.Suche in Google Scholar

Kanner, A.M (2003). Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol. Psychiatr. 54: 388–398, https://doi.org/10.1016/s0006-3223(03)00469-4.Suche in Google Scholar

Kazemi, M., Shokri, S., Ganjkhani, M., Ali, R., and Iraj, J.A. (2016). Modulation of axonal sprouting along rostro-caudal axis of dorsal hippocampus and no neuronal survival in parahippocampal cortices by long-term post-lesion melatonin administration in lithium-pilocarpine model of temporal lobe epilepsy. Anatomy & cell biology 49: 21–33, https://doi.org/10.5115/acb.2016.49.1.21.Suche in Google Scholar

Kim, H.A., Lee, K.H., and Lee, B.H. (2014). Neuroprotective effect of melatonin against kainic acid-induced oxidative injury in hippocampal slice culture of rats. Int. J. Mol. Sci. 15: 5940–5951, https://doi.org/10.3390/ijms15045940.Suche in Google Scholar

Koguchi, M., Nakahara, Y., Ebashi, R., Ogata, A., Shimokawa, S., Masuoka, J., and Abe, T. (2019). Status epilepticus induced by treatment with dopamine agonist therapy for giant prolactinoma: a case report. J. Med. Case Rep. 13: 18, https://doi.org/10.1186/s13256-018-1939-x.Suche in Google Scholar

Kostoglou-Athanassiou, I. (2013). Therapeutic applications of melatonin. Ther Adv Endocrinol Metab 4: 13–24, https://doi.org/10.1177/2042018813476084.Suche in Google Scholar

Landolt, H.P., and Wehrle, R. (2009). Antagonism of serotonergic 5‐HT2A/2C receptors: mutual improvement of sleep, cognition and mood?. Eur. J. Neurosci. 29: 1795–1809, https://doi.org/10.1111/j.1460-9568.2009.06718.x.Suche in Google Scholar

Lapin, L.P., Mirzaev, S.M., Ryzov, I.V., and Oxenkrug, G.F. (1998). Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. J. Pineal Res. 24: 215–218, https://doi.org/10.1111/j.1600-079x.1998.tb00535.x.Suche in Google Scholar

León, J., Macías, M., Escames, G., Camacho, E., Khaldy, H., Martín, M., Espinosa, A., Gallo, M.A., and Acuña-Castroviejo, D. (2000). Structure-related inhibition of calmodulin-dependent neuronal nitric-oxide synthase activity by melatonin and synthetic kynurenines. Mol. Pharmacol. 58: 967–975, https://doi.org/10.1124/mol.58.5.967.Suche in Google Scholar

Lima, E., Cabral, F.R., Cavalheiro, E.A., Naffah-Mazzacoratti Mda, G., and Amado, D. (2011). Melatonin administration after pilocarpine-induced status epilepticus: a new way to prevent or attenuate postlesion epilepsy?. Epilepsy Behav. 20: 607–612, https://doi.org/10.1016/j.yebeh.2011.01.018.Suche in Google Scholar

Liu, Y.-Y., Yin, D., Chen, L., Qu, W.-M., Chen, C.-R., Laudon, M., Cheng, N.-N., Urade, Y., and Huang, Z.-L. (2014). Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT 1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain. Psychopharmacology 231: 3973–3985, https://doi.org/10.1007/s00213-014-3530-5.Suche in Google Scholar

Ma, Y., Sun, X., Li, J., Jia, R., Yuan, F., Wei, D., and Jiang, W. (2017). Melatonin alleviates the epilepsy-associated impairments in hippocampal LTP and spatial learning through rescue of surface GluR2 expression at hippocampal CA1 synapses. Neurochem. Res. 42: 1438–1448, https://doi.org/10.1007/s11064-017-2200-5.Suche in Google Scholar

Mahyar, A., Ayazi, P., Dalirani, R., Gholami, N., DANESHIKOHAN, M.M., Mohammadi, N., Ahmadi, M.H., and Sahmani, A.A. (2014). Melatonin’s effect in febrile seizures and epilepsy. Iran. J. Child Neurol. 8: 24.Suche in Google Scholar

Majidinia, M., Sadeghpour, A., Mehrzadi, S., Reiter, R.J., Khatami, N., and Yousefi, B. (2017). Melatonin: a pleiotropic molecule that modulates DNA damage response and repair pathways. J. Pineal Res. 63: e12416, https://doi.org/10.1111/jpi.12416.Suche in Google Scholar

Manev, H., Uz, T., Kharlamov, A., and Joo, J. (1996). Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats. Faseb. J. 10: 1546–1551, https://doi.org/10.1096/fasebj.10.13.8940301.Suche in Google Scholar

Mayer, G., Wang-Weigand, G., Roth-Schechter, B., Lehmann, R., Staner, C., and Partinen, M. (2009). Efficacy and safety of 6-month nightly ramelteon administration in adults with chronic primary insomnia. Sleep 32: 351–360, https://doi.org/10.1093/sleep/32.3.351.Suche in Google Scholar

Milanese, M., Tardito, D., Musazzi, L., Treccani, G., Mallei, A., Bonifacino, T., Gabriel, C., Mocaer, E., Racagni, G., and Popoli, M. (2013). Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes. BMC Neurosci. 14: 75, https://doi.org/10.1186/1471-2202-14-75.Suche in Google Scholar

Millan, M., Gobert, A., Lejeune, F., Dekeyne, A., Newman-Tancredi, A., Pasteau, V., Rivet, J.-M., and Cussac, D. (2003). The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J. Pharmacol. Exp. Therapeut. 306: 954–964, https://doi.org/10.1124/jpet.103.051797.Suche in Google Scholar

Miyamoto, M., Nishikawa, H., Ota, H., Uchikawa, O., and Ohkawa, S. (2003). Behavioral pharmacology of ramelteon (TAK-375) in small mammals. Annals of Neurology. New York, NY, USA): Wiley-Liss, pp. S46.Suche in Google Scholar

Molina-Carballo, A., Munoz-Hoyos, A., Sánchez-Forte, M., Uberos-Fernández, J., Moreno-Madrid, F., and Acuña-Castroviejo, D. (2007). Melatonin increases following convulsive seizures may be related to its anticonvulsant properties at physiological concentrations. Neuropediatrics 38: 122–125, https://doi.org/10.1055/s-2007-985138.Suche in Google Scholar

Molina‐Carballo, A., Muñoz‐Hoyos, A., Reiter, R.J., Sánchez‐Forte, M., Moreno‐Madrid, F., Rufo‐Campos, M., Molina‐Font, J.A., and Acuna‐Castroviejo, D. (1997). Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years’ experience. J. Pineal Res. 23: 97–105, https://doi.org/10.1111/j.1600-079x.1997.tb00341.x.Suche in Google Scholar

Mosińska, P., Socała, K., Nieoczym, D., Laudon, M., Storr, M., Fichna, J., and Wlaź, P. (2016). Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice. Behav. Brain Res. 307: 199–207. https://doi.org/10.1016/j.bbr.2016.03.036.Suche in Google Scholar

Moyanova, S., De Fusco, A., Santolini, I., Celli, R., Bucci, D., Mastroiacovo, F., Battaglia, G., Nicoletti, F., and Tchekalarova, J. (2018). Abnormal hippocampal melatoninergic system: a potential link between absence epilepsy and depression-like behavior in WAG/rij rats?. Int. J. Mol. Sci. 19: 1973, https://doi.org/10.3390/ijms19071973.Suche in Google Scholar

Munoz-Hoyos, A., Molina-Carballo, A., Macias, M., Rodriguez-Cabezas, T., Martin-Medina, E., Narbona-Lopez, E., Valenzuela-Ruiz, A., and Acuna-Castroviejo, D. (1998). Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress. Eur. J. Endocrinol. 139: 89–95, https://doi.org/10.1530/eje.0.1390089.Suche in Google Scholar

Ng, K.Y., Leong, M.K., Liang, H., and Paxinos, G. (2017). Melatonin receptors: distribution in mammalian brain and their respective putative functions. Brain Struct. Funct. 222: 2921–2939, https://doi.org/10.1007/s00429-017-1439-6.Suche in Google Scholar

Niles, L.P., Sathiyapalan, A., Bahna, S., Kang, N.H., and Pan, Y. (2012). Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain. Int. J. Neuropsychopharmacol. 15: 1343–1350, https://doi.org/10.1017/s1461145711001969.Suche in Google Scholar

Pappert, E., Goetz, C., Vu, T., Ling, Z., Leurgans, S., Raman, R., and Carvey, P. (1999). Animal model of posthypoxic myoclonus: effects of serotonergic antagonists. Neurology 52: 16, https://doi.org/10.1212/wnl.52.1.16.Suche in Google Scholar

Peled, N., Shorer, Z., Peled, E., and Pillar, G. (2001). Melatonin effect on seizures in children with severe neurologic deficit disorders. Epilepsia 42: 1208–1210, https://doi.org/10.1046/j.1528-1157.2001.28100.x.10.1046/j.1528-1157.2001.28100.xSuche in Google Scholar

Pharmaceuticals, N (2013). Neurim pharmaceuticals announces positive phase 2 clinical trial results of piromelatine for the treatment of insomnia. Israel: Neurim Pharmacuticals. Available at: https://www.prnewswire.com/in/news-releases (Accessed 28 Aug, 2020).Suche in Google Scholar

Praninskiene, R., Dumalakiene, I., Kemezys, R., Mauricas, M., and Jucaite, A. (2012). Melatonin secretion in children with epilepsy. Epilepsy Behav. 25: 315–322, https://doi.org/10.1016/j.yebeh.2012.08.012.Suche in Google Scholar

Racagni, G. Riva, Molteni, R., Musazzi, L., Calabrese, F., Popoli, M., and Tardito, D. (2011). Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors. World J. Biol. Psych. 12: 574–587.10.3109/15622975.2011.595823Suche in Google Scholar

Rao, M.L., Stefan, H., and Bauer, J. (1989). Epileptic but not psychogenic seizures are accompanied by simultaneous elevation of serum pituitary hormones and cortisol levels. Neuroendocrinology 49: 33–39, https://doi.org/10.1159/000125088.Suche in Google Scholar

Reddy, D.S., Chuang, S.-H., Hunn, D., Crepea, A.Z., and Magant, R. (2018). Neuroendocrine aspects of improving sleep in epilepsy. Epilepsy Res, https://doi.org/10.1016/j.eplepsyres.2018.08.013.Suche in Google Scholar

Reiter, R., C Manchester, L., and Tan, D.-X. (2010). Neurotoxins: free radical mechanisms and melatonin protection. Curr. Neuropharmacol. 8: 194–210.10.2174/157015910792246236Suche in Google Scholar

Reiter, R., Tan, D., Rosales-Corral, S., Galano, A., Zhou, X., and Xu, B. (2018). Mitochondria: central organelles for melatonin′ s antioxidant and anti-aging actions. Molecules 23: 509, https://doi.org/10.3390/molecules23020509.Suche in Google Scholar

Renkawek, K., Renier, W., de Pont, J., Vogels, O., and Gabreels, F. (1992). Neonatal status convulsivus, spongiform encephalopathy, and low activity of Na+/K+‐ATPase in the brain. Epilepsia 33: 58–64, https://doi.org/10.1111/j.1528-1157.1992.tb02283.x.Suche in Google Scholar

Reppart, S.M., Weaver, D.R., and Godson, C. (1996). Melatonin receptors step into the light: cloning and classification of subtypes. Trends Pharmacol. Sci. 17: 100–102, https://doi.org/10.1016/0165-6147(96)10005-5.Suche in Google Scholar

Rocha, A., de Lima, E., Amaral, F., Peres, R., Cipolla-Neto, J., and Amado, D. (2017). Altered MT1 and MT2 melatonin receptors expression in the hippocampus of pilocarpine-induced epileptic rats. Epilepsy Behav. 71: 23–34, https://doi.org/10.1016/j.yebeh.2017.01.020.Suche in Google Scholar

Satyanarayanan, S.K., Shih, Y.-H., Chien, Y.-C., Huang, S.-Y., Gałecki, P., Kasper, S., Chang, J.P.-C., and Su, K.-P. (2018). Anti-oxidative effects of melatonin receptor agonist and omega-3 polyunsaturated fatty acids in neuronal SH-SY5Y cells: deciphering synergic effects on anti-depressant mechanisms. Mol. Neurobiol.: 1–14.10.1007/s12035-018-0899-xSuche in Google Scholar PubMed

Scheffer, I.E., Berkovic, S., Capovilla, G., Connolly, M.B., French, J., Guilhoto, L., Hirsch, E., Jain, S., Mathern, G.W., and Moshé, S.L. (2017). ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia 58: 512–521, https://doi.org/10.1111/epi.13709.Suche in Google Scholar

Seierstad, M., and Breitenbucher, J.G. (2008). Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J. Med. Chem. 51: 7327–7343, https://doi.org/10.1021/jm800311k.Suche in Google Scholar

She, M., Hu, X., Su, Z., Zhang, C., Yang, S., Ding, L., Laudon, M., and Yin, W. (2014). Piromelatine, a novel melatonin receptor agonist, stabilizes metabolic profiles and ameliorates insulin resistance in chronic sleep restricted rats. Eur. J. Pharmacol. 727: 60–65, https://doi.org/10.1016/j.ejphar.2014.01.037.Suche in Google Scholar

Solmaz, İ., Gürkanlar, D., Gökçil, Z., Göksoy, C., Özkan, M., and Erdoğan, E. (2009). Antiepileptic activity of melatonin in Guinea pigs with pentylenetetrazol-induced seizures. Neurol. Res. 31: 989–995, https://doi.org/10.1179/174313209x385545.Suche in Google Scholar

Srinivasan, V., Pandi-Perumal, S., Cardinali, D., Poeggeler, B., and Hardeland, R. (2006). Melatonin in Alzheimer’s disease and other neurodegenerative disorders. Behav. Brain Funct. 2: 15, https://doi.org/10.1186/1744-9081-2-15.Suche in Google Scholar

Stein, D.J., Ahokas, A., Albarran, C., Olivier, V., and Allgulander, C. (2012). Agomelatine prevents relapse in generalized anxiety disorder: a 6-month randomized, double-blind, placebo-controlled discontinuation study. J. Clin. Psychiat. 73: 1002–1008.10.4088/JCP.11m07493Suche in Google Scholar PubMed

Stein, D.J., Ahokas, A. Márquez, Höschl, C., and Olivier, V. (2014). Original research agomelatine in generalized anxiety disorder: an active comparator and placebo-controlled study. J. Clin. Psychiat. 75: 362–368.10.4088/JCP.13m08433Suche in Google Scholar PubMed

Stein, D.J., Ahokas, A., Jarema, M. Avedisova, Vavrusova, L., Chaban, O., Gruget, C., Olivier, V., Picarel-Blanchot, F., and De, Bodinat. (2017). Efficacy and safety of agomelatine (10 or 25 mg/day) in non-depressed out-patients with generalized anxiety disorder: a 12-week, double-blind, placebo-controlled study. Europ. Neuropsychopharm. 27: 526–537.10.1016/j.euroneuro.2017.02.007Suche in Google Scholar PubMed

Stein, D.J., Khoo, J.-P., Ahokas, A., Jarema, M., Van, Ameringen, Vavrusova, L., Höschl, C., Bauer, M., Bitter, I., and Mosolov, S.N. (2018). 12-week double-blind randomized multicenter study of efficacy and safety of agomelatine (25–50 mg/day) versus escitalopram (10–20 mg/day) in out-patients with severe generalized anxiety disorder. Europ. Neuropsychopharm. 28: 970–979.10.1016/j.euroneuro.2018.05.006Suche in Google Scholar PubMed

Stein, D.J., Picarel‐Blanchot, F., and Kennedy, S.H. (2013). Efficacy of the novel antidepressant agomelatine for anxiety symptoms in major depression. Hum. Psychopharm. Clin. Experiment. 28: 151–159.10.1002/hup.2294Suche in Google Scholar PubMed

Stout, B.D., Clarke, W.P., and Berg, K.A. (2002). Rapid desensitization of the serotonin2C receptor system: effector pathway and agonist dependence. J. Pharmacol. Exp. Therapeut. 302: 957–962, https://doi.org/10.1124/jpet.302.3.957.Suche in Google Scholar

Sugawara, T., Tsurubuchi, Y., Agarwala, K.L., Ito, M., Fukuma, G., Mazaki-Miyazaki, E., Nagafuji, H., Noda, M., Imoto, K., and Wada, K. (2001). A missense mutation of the Na+ channel αII subunit gene Nav1. 2 in a patient with febrile and afebrile seizures causes channel dysfunction. Proc. Natl. Acad. Sci. U.S.A. 98: 6384–6389, https://doi.org/10.1073/pnas.111065098.Suche in Google Scholar

Sugden, D., Davidson, K., Hough, K.A., and Teh, M.T. (2004). Melatonin, melatonin receptors and melanophores: a moving story. Pigm. Cell Res. 17: 454–460, https://doi.org/10.1111/j.1600-0749.2004.00185.x.Suche in Google Scholar

Suofu, Y., Li, W., Jean-Alphonse, F.G., Jia, J., Khattar, N.K., Li, J., Baranov, S.V., Leronni, D., Mihalik, A.C., and He, Y. (2017). Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release. Proc. Natl. Acad. Sci. U.S.A. 114: E7997–E8006, https://doi.org/10.1073/pnas.1705768114.Suche in Google Scholar

Tchekalarova, J., Atanasova, D., Nenchovska, Z., Atanasova, M., Kortenska, L., Gesheva, R., and Lazarov, N. (2017). Agomelatine protects against neuronal damage without preventing epileptogenesis in the kainate model of temporal lobe epilepsy. Neurobiol. Dis. 104: 1–14, https://doi.org/10.1016/j.nbd.2017.04.017.Suche in Google Scholar

Thomovsky, S.A., Chen, A.V., Deavila, D.M., and Kiszonas, A.M. (2019). Serum melatonin values in normal dogs and dogs with seizures. J. Am. Anim. Hosp. Assoc. 55: 78–82, https://doi.org/10.5326/jaaha-ms-6669.Suche in Google Scholar

Tian, S.W., Laudon, M., Han, L., Gao, J., Huang, F.L., Yang, Y.F., and Deng, H.F. (2010). Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models. Acta Pharmacol. Sin. 31: 775–783, https://doi.org/10.1038/aps.2010.80.Suche in Google Scholar

Tordjman, S., Chokron, S., Delorme, R., Charrier, A., Bellissant, E., Jaafari, N., and Fougerou, C. (2017). Melatonin: pharmacology, functions and therapeutic benefits. Curr. Neuropharmacol. 15: 434–443, https://doi.org/10.2174/1570159x14666161228122115.Suche in Google Scholar

Treiman, D.M. (2001). GABAergic mechanisms in epilepsy. Epilepsia 42: 8–12, https://doi.org/10.1046/j.1528-1157.2001.042suppl.3008.x.Suche in Google Scholar

Uberos, J., Augustin‐Morales, M., Molina Carballo, A., Florido, J., Narbona, E., and Muñoz‐Hoyos, A. (2011). Normalization of the sleep–wake pattern and melatonin and 6‐sulphatoxy‐melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy. J. Pineal Res. 50: 192–196, https://doi.org/10.1111/j.1600-079x.2010.00828.x.Suche in Google Scholar

Uchiyama, M., Hamamura, M., Kuwano, T., Nishiyama, H., Nagata, H., and Uchimura, N. (2011). Evaluation of subjective efficacy and safety of ramelteon in Japanese subjects with chronic insomnia. Sleep Med. 12: 119–126, https://doi.org/10.1016/j.sleep.2010.08.010.Suche in Google Scholar

Waldbaum, S., and Patel, M. (2010). Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?. J. Bioenerg. Biomembr. 42: 449–455, https://doi.org/10.1007/s10863-010-9320-9.Suche in Google Scholar

Wang-Weigand, S., McCue, M., Ogrinc, F., and Mini, L. (2009). Effects of ramelteon 8 mg on objective sleep latency in adults with chronic insomnia on nights 1 and 2: pooled analysis. Curr. Med. Res. Opin. 25: 1209–1213, https://doi.org/10.1185/03007990902858527.Suche in Google Scholar

WHO Factsheet (2018). Geneva: World health Organisation.Suche in Google Scholar

Xue, F., Shi, C., Chen, Q., Hang, W., Xia, L., Wu, Y., Tao, S.Z., Zhou, J., Shi, A., and Chen, J. (2017). Melatonin mediates protective effects against kainic acid-induced neuronal death through safeguarding ER stress and mitochondrial disturbance. Front. Mol. Neurosci. 10: 49, https://doi.org/10.3389/fnmol.2017.00049.Suche in Google Scholar

Yahyavi-Firouz-Abadi, N., Tahsili-Fahadan, P., Riazi, K., Ghahremani, M.H., and Dehpour, A.R. (2007). Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: role for nitric oxide signaling pathway. Epilepsy Res. 75: 138–144, https://doi.org/10.1016/j.eplepsyres.2007.05.002.Suche in Google Scholar

Yang, Z.-X., and Qin, J. (2004). Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of recurrent febrile seizures. Biochem. Biophys. Res. Commun. 315: 349–355, https://doi.org/10.1016/j.bbrc.2004.01.061.Suche in Google Scholar

Yigitturk, G., Acara, A.C., Erbas, O., Oltulu, F., Yavasoglu, N.U.K., Uysal, A., and Yavasoglu, A. (2017). The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes. Biomed. Pharmacother. 87: 240–246, https://doi.org/10.1016/j.biopha.2016.12.102.Suche in Google Scholar

Yildirim, M., and Marangoz, C. (2006). Anticonvulsant effects of melatonin on penicillin-induced epileptiform activity in rats. Brain Res. 1099: 183–188, https://doi.org/10.1016/j.brainres.2006.04.093.Suche in Google Scholar

Yukuhiro, N., Kimura, H., Nishikawa, H., Ohkawa, S., Yoshikubo, S.-I., and Miyamoto, M. (2004). Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys. Brain Res. 1027: 59–66.10.1016/j.brainres.2004.08.035Suche in Google Scholar PubMed