Abstract
Multiple sclerosis has always been an enigma to its sufferers, their families, medical investigators, and clinicians. For many centuries, there have been attempts to understand its causes and nature, and to discover treatment methods. In the Middle Ages, the disease was claimed to be sent directly from God. A significant development in exploring multiple sclerosis took place in the 19th century, when Jean-Martin Charcot and his colleagues distinguished the disease, precisely described its symptoms, attempted to explain its pathophysiology, and introduced the first methods of symptomatic treatment. The 20th century was a period of discovery and development of diagnostic techniques, such as cerebrospinal fluid analysis, evoked potentials, and magnetic resonance imaging as well as an era of introducing steroid therapy for acute treatment. Currently, the dynamic development of disease modifying therapy and neuroimaging can be observed. The paper aims to delve into the remarkable history of multiple sclerosis by focusing on the earliest case reports and discovery of the disease and exploring its nature, diagnostic methods, and treatment.
Acknowledgments
The proofreading service was provided by ‘English Prep Biuro Językowe’ (kontakt@englishprep.pl). This article did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Conflict of interest statement: None to declare.
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Artikel in diesem Heft
- Frontmatter
- Alpha-synuclein in salivary gland as biomarker for Parkinson’s disease
- Determining the early corticospinal-motoneuronal responses to strength training: a systematic review and meta-analysis
- The role of neurovascular unit damage in the occurrence and development of Alzheimer’s disease
- Functions of adiponectin signaling in regulating neural plasticity and its application as the therapeutic target to neurological and psychiatric diseases
- A review of the use of EEG connectivity to measure the neurological characteristics of the sensory features in young people with autism
- Multiple sclerosis – the remarkable story of a baffling disease
- Melatonin and its anti-glioma functions: a comprehensive review
- The role of fibroblast growth factors and their receptors in gliomas: the mutations involved
- Application of quercetin in neurological disorders: from nutrition to nanomedicine
Artikel in diesem Heft
- Frontmatter
- Alpha-synuclein in salivary gland as biomarker for Parkinson’s disease
- Determining the early corticospinal-motoneuronal responses to strength training: a systematic review and meta-analysis
- The role of neurovascular unit damage in the occurrence and development of Alzheimer’s disease
- Functions of adiponectin signaling in regulating neural plasticity and its application as the therapeutic target to neurological and psychiatric diseases
- A review of the use of EEG connectivity to measure the neurological characteristics of the sensory features in young people with autism
- Multiple sclerosis – the remarkable story of a baffling disease
- Melatonin and its anti-glioma functions: a comprehensive review
- The role of fibroblast growth factors and their receptors in gliomas: the mutations involved
- Application of quercetin in neurological disorders: from nutrition to nanomedicine