Startseite Cognitive impairment in multiple sclerosis – a review of current knowledge and recent research
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Cognitive impairment in multiple sclerosis – a review of current knowledge and recent research

  • Tomasz Grzegorski ORCID logo EMAIL logo und Jacek Losy
Veröffentlicht/Copyright: 8. August 2017
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Abstract

Multiple sclerosis (MS) is a chronic, progressive disease of the central nervous system that is characterised by inflammatory damage to the myelin sheath. Though often neglected, cognitive impairment is a common feature of MS that affects 43–70% of patients. It has a sophisticated neuroanatomic and pathophysiologic background and disturbs such vital cognitive domains as speed of information processing, memory, attention, executive functions and visual perceptual functions. In recent years there has been growing interest in neuroimaging findings with regard to cognitive impairment in MS. The possible options of managing cognitive dysfunction in MS are pharmacologic interventions, cognitive rehabilitation and exercise training; however, not enough evidence has been presented in this field. The aim of our article is to provide current knowledge on cognitive impairment in MS based on the most recent scientific results and conclusions with regard to affected cognitive domains, neuropsychological assessment, underlying mechanisms of this disturbance, neuroimaging findings and therapeutic options.

Acknowledgments

Proofreading service was provided by ‘English Prep Biuro Językowe’ (kontakt@englishprep.pl). This article did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.

References

Adler, G. and Lembach, Y. (2015). Memory and selective attention in multiple sclerosis: cross-sectional computer-based assessment in a large outpatient sample. Eur. Arch. Psychiatry Clin. Neurosci. 265, 439–443.10.1007/s00406-015-0574-4Suche in Google Scholar PubMed

Amato, M.P., Goretti, B., Ghezzi, A., Lori, S., Zipoli, V., Moiola, L., Falautano, M., De Caro, M.F., Viterbo, R., Patti, F., et al. (2010). Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up. Neurology 75, 1134–1140.10.1212/WNL.0b013e3181f4d821Suche in Google Scholar PubMed

Amato, M.P., Hakiki, B., Goretti, B., Rossi, F., Stromillo, M.L., Giorgio, A., Roscio, M., Ghezzi, A., Guidi, L., Bartolozzi, M.L., et al. (2012). Association of MRI metrics and cognitive impairment in radiologically isolated syndromes. Neurology 78, 309–314.10.1212/WNL.0b013e31824528c9Suche in Google Scholar PubMed

Arnett, P.A., Higginson, C.I., and Randolph, J.J. (2001). Depression in multiple sclerosis: relationship to planning ability. J. Int. Neuropsychol. Soc. 7, 665–674.10.1017/S1355617701766027Suche in Google Scholar PubMed

Audoin, B., Au Duong, M.V., Malikova, I., Confort-Gouny, S., Ibarrola, D., Cozzone, P.J., Pelletier, J. and Ranjeva, J.P. (2006). Functional magnetic resonance imaging and cognition at the very early stage of MS. J. Neurol. Sci. 245, 87–91.10.1016/j.jns.2005.08.026Suche in Google Scholar PubMed

Beatty, W.W. and Aupperle, R.L. (2002). Sex differences in cognitive impairment in multiple sclerosis. Clin. Neuropsychol. 16, 472–480.10.1076/clin.16.4.472.13904Suche in Google Scholar PubMed

Beatty, W.W., Goodkin, D.E., Monson, N., and Beatty, P.A. (1990). Implicit learning in patients with chronic progressive multiple sclerosis. Int. J. Clin. Neuropsychol. 12, 166–172.Suche in Google Scholar

Beatty, W.W., Paul, R.H., Blanco, C.R., Hames, K.A., and Wilbanks, S.L. (1995). Attention in multiple sclerosis: correlates of impairment on the WAIS-R digit span test. Appl. Neuropsychol. 2, 139–144.10.1080/09084282.1995.9645351Suche in Google Scholar PubMed

Benedict, R.H. and Bobholz, J.H. (2007). Multiple sclerosis. Semin. Neurol. 27, 78–85.10.1055/s-2006-956758Suche in Google Scholar PubMed

Benedict, R.H. and Zivadinov, R. (2011). Risk factors for and management of cognitive dysfunction in multiple sclerosis. Nat. Rev. Neurol. 7, 332–342.10.1038/nrneurol.2011.61Suche in Google Scholar PubMed

Benedict, R.H., Fischer, J.S., Archibald, C.J., Arnett, P.A., Beatty, W.W., Bobholz, J., Chelune, G.J., Fisk, J.D., Langdon, D.W., Caruso, L., et al. (2002). Minimal neuropsychological assessment of MS patients: a consensus approach. Clin. Neuropsychol. 16, 381–397.10.1076/clin.16.3.381.13859Suche in Google Scholar PubMed

Benedict, R.H., Carone, D.A., and Bakshi, R. (2004). Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis. J. Neuroimaging 14(Suppl.), 36–45.10.1177/1051228404266267Suche in Google Scholar PubMed

Benedict, R.H., Cookfair, D., Gavett, R., Gunther, M., Munschauer, F., Garg, N., and Weinstock-Guttman, B. (2006). Validity of the minimal assessment of cognitive function in multiple sclerosis. J. Int. Neuropsychol. Soc. 12, 549–558.10.1017/S1355617706060723Suche in Google Scholar PubMed

Benedict, R.H., Amato, M.P., Boringa, J., Brochet, B., Foley, F., Fredrikson, S., Hamalainen, P., Hartung, H., Krupp, L., Penner, I., et al. (2012). Brief international cognitive assessment for MS (BICAMS): international standards for validation. BMC Neurol. 12, 55.10.1186/1471-2377-12-55Suche in Google Scholar PubMed PubMed Central

Bergendal, G., Fredrikson, S., and Almkvist, O. (2007). Selective decline in information processing in subgroups of multiple sclerosis: an 8 year old longitudinal study. Eur. Neurol. 57, 193–202.10.1159/000099158Suche in Google Scholar PubMed

Bergsland, N., Zivadinov, R., Dwyer, M.G., Weinstock-Guttman, B., and Benedict, R.H. (2016). Localized atrophy of the thalamus and slowed cognitive processing speed in MS patients. Mult. Scler. 22, 1327–1336.10.1177/1352458515616204Suche in Google Scholar PubMed

Bisecco, A., Stamenova, S., Caiazzo, G., d’Ambrosio, A., Sacco, R., Docimo, R., Esposito, S., Cirillo, M., Esposito, F., Bonavita, S., et al. (2017). Attention and processing speed performance in multiple sclerosis is mostly related to thalamic volume. Brain Imaging Behav. (Epub ahead of print).10.1007/s11682-016-9667-6Suche in Google Scholar PubMed

Bodling, A.M., Denney, D.R., and Lynch, S.G. (2009). Cognitive aging in patients with multiple sclerosis: a cross-sectional analysis of speeded processing. Arch. Clin. Neuropsychol. 24, 761–767.10.1093/arclin/acp076Suche in Google Scholar PubMed

Bora, E., Özakbaş, S., Velakoulis, D., and Walterfang, M. (2016). Social cognition in multiple sclerosis: a meta-analysis. Neuropsychol. Rev. 26, 160–172.10.1007/s11065-016-9320-6Suche in Google Scholar PubMed

Brissart, H., Morele, E., Baumann, C., and Debouverie, M. (2012). Verbal episodic memory in 426 multiple sclerosis patients: impairment in encoding, retrieval or both? Neurol. Sci. 33, 1117–1123.10.1007/s10072-011-0915-7Suche in Google Scholar PubMed

Brooks, J.B., Borela, M.C., and Fragoso, Y.D. (2011). Assessment of cognition using the Rao’s Brief Repeatable Battery of Neuropsychological Tests on a group of Brazilian patients with multiple sclerosis. Arq. Neuropsiquiatr. 69, 887–891.10.1590/S0004-282X2011000700007Suche in Google Scholar PubMed

Bruce, J.M., Bruce, A.S., and Arnett, P.A. (2007). Mild visual acuity disturbances are associated with performance on tests of complex visual attention in MS. J. Int. Neuropsychol. Soc. 13, 544–548.10.1017/S1355617707070658Suche in Google Scholar PubMed

Bunyan, R.F., Popescu, B.F., Carter, J.L., Caselli, R.J., Parisi, J.E., and Lucchinetti, C.F. (2011). Childhood-onset multiple sclerosis with progressive dementia and pathological cortical demyelination. Arch. Neurol. 68, 525–528.10.1001/archneurol.2011.50Suche in Google Scholar PubMed

Caine, E.D., Bamford, K.A., Schiffer, R.B., Shoulson, I., and Levy, S. (1986). A controlled neuropsychological comparison of Huntington’s disease and multiple sclerosis. Arch. Neurol. 43, 249–254.10.1001/archneur.1986.00520030039009Suche in Google Scholar PubMed

Calabrese, M., Agosta, F., Rinaldi, F., Mattisi, I., Grossi, P., Favaretto, A., Atzori, M., Bernardi, V., Barachino, L., Rinaldi, L., et al. (2009). Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis. Arch. Neurol. 66, 1144–1150.10.1001/archneurol.2009.174Suche in Google Scholar PubMed

Calabresi, P.A., Radue, E.W., Goodin, D., Jeffery, D., Rammohan, K.W., Reder, A.T., Vollmer, T., Agius, M.A., Kappos, L., Stites, T., et al. (2014). Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Neurol. 13, 545–556.10.1016/S1474-4422(14)70049-3Suche in Google Scholar

Caligiuri, M.E., Barone, S., Cherubini, A., Augimeri, A., Chiriaco, C., Trotta, M., Granata, A., Filippelli, E., Perrotta, P., Valentino, P., et al. (2014). The relationship between regional microstructural abnormalities of the corpus callosum and physical and cognitive disability in relapsing-remitting multiple sclerosis. Neuroimage Clin. 7, 28–33.10.1016/j.nicl.2014.11.008Suche in Google Scholar PubMed

Carmona, O., Masuet, C., Santiago, O., Alía, P., Moral, E., Alonso-Magdalena, L., Casado, V., and Arbizu, T. (2011). Multiple sclerosis and cognitive decline: is ApoE-4 a surrogate marker? Acta Neurol. Scand. 124, 258–263.10.1111/j.1600-0404.2010.01473.xSuche in Google Scholar PubMed

Charcot, J.M. (1877). Lectures on the Diseases on the Nervous System Delivered at La Salpetrière (London: New Sydenham Society).Suche in Google Scholar

Chenet, A., Gosseaume, A., Wiertlewski, S., and Perrouin-Verbe, B. (2016). Efficacity of exercise training on multiple sclerosis patients with cognitive impairments. Ann. Phys. Rehabil. Med. 59(Suppl.), e42.10.1016/j.rehab.2016.07.097Suche in Google Scholar

Chiaravalloti, N.D. and DeLuca, J. (2008). Cognitive impairment in multiple sclerosis. Lancet Neurol. 7, 1139–1151.10.1016/S1474-4422(08)70259-XSuche in Google Scholar PubMed

Chiaravalloti, N.D., Demaree, H., Gaudino, E.A., and DeLuca, J. (2003). Can the repetition effect maximize learning in multiple sclerosis? Clin. Rehabil. 17, 58–68.10.1191/0269215503cr586oaSuche in Google Scholar PubMed

Chiaravalloti, N.D., Wylie, G., Leavitt, V., and Deluca, J. (2012). Increased cerebral activation after behavioral treatment for memory deficits in MS. J. Neurol. 259, 1337–1346.10.1007/s00415-011-6353-xSuche in Google Scholar PubMed

Chiaravalloti, N.D., Genova, H.M., and DeLuca, J. (2015). Cognitive rehabilitation in multiple sclerosis: the role of plasticity. Front. Neurol. 6, 67.10.3389/fneur.2015.00067Suche in Google Scholar PubMed

Chillemi, G., Scalera, C., Terranova, C., Calamuneri, A., Buccafusca, M., Dattola, V., Rizzo, V., Bruschetta, D., Girlanda, P., and Quartarone, A. (2015). Cognitive processess and cognitive reserve in multiple sclerosis. Arch. Ital. Biol. 153, 19–24.10.12871/00039829201512Suche in Google Scholar PubMed

Cinar, B.P., Kösehasanoğulları, G., Yigit, P., and Ozakbas, S. (2017). Cognitive dysfunction in patients with multiple sclerosis treated with first-line disease-modifying therapy: a multi-center, controlled study using the BICAMS battery. Neurol. Sci. 38, 337–342.10.1007/s10072-016-2775-7Suche in Google Scholar PubMed

Compston, A. and Coles, A. (2008). Multiple sclerosis. Lancet 372, 1502–1517.10.1016/S0140-6736(08)61620-7Suche in Google Scholar PubMed

Dagenais, E., Rouleau, I., Tremblay, A., Demers, M., Roger, É., Jobin, C., and Duquette, P. (2016). Role of executive functions in prospective memory in multiple sclerosis: impact of the strength of cue-action association. J. Clin. Exp. Neuropsychol. 38, 127–140.10.1080/13803395.2015.1091063Suche in Google Scholar PubMed

das Nair, R., Martin, K.J., and Lincoln, N.B. (2016). Memory rehabilitation for people with multiple sclerosis. Cochrane Database Syst. Rev. 3, CD008754.10.1002/14651858.CD008754.pub3Suche in Google Scholar PubMed

De Giglio, L., De Luca, F., Prosperini, L., Borriello, G., Bianchi, V., Pantano, P., and Pozzilli, C. (2015). A low-cost cognitive rehabilitation with a commercial video game improves sustained attention and executive functions in multiple sclerosis: a pilot study. Neurorehabil. Neural Repair 29, 453–461.10.1177/1545968314554623Suche in Google Scholar PubMed

Deloire, M., Ruet, A., Hamel, D., Bonnet, M., and Brochet, B. (2010). Early cognitive impairment in multiple sclerosis predicts disability outcome several years later. Mult. Scler. 16, 581–587.10.1177/1352458510362819Suche in Google Scholar PubMed

DeLuca, G.C., Yates, R.L., Beale, H., and Morrow, S.A. (2015). Cognitive impairment in multiple sclerosis: clinical, radiologic and pathologic insights. Brain Pathol. 25, 79–98.10.1111/bpa.12220Suche in Google Scholar PubMed PubMed Central

DeLuca, J. (2005). Fatigue, cognition, and mental effort. In: Fatigue as a Window to the Brain. J. DeLuca, ed. (Cambridge, MA, USA: MIT Press), pp. 37–57.10.7551/mitpress/2967.003.0006Suche in Google Scholar

DeLuca, J., Gaudino, E.A., Diamond, B.J., Christodoulou, C., and Engel, R.A. (1998). Acquisition and storage deficits in multiple sclerosis. J. Clin. Exp. Neuropsychol. 20, 376–390.10.1076/jcen.20.3.376.819Suche in Google Scholar PubMed

Diker, S., Has, A.C., Kurne, A., Göçmen, R., Oğuz, K.K., and Karabudak, R. (2016). The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome. Mult. Scler. Relat. Disord. 10, 14–21.10.1016/j.msard.2016.08.008Suche in Google Scholar PubMed

Dineen, R.A., Vilisaar, J., Hlinka, J., Bradshaw, C.M., Morgan, P.S., Constantinescu, C.S., and Auer, D.P. (2009). Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis. Brain 132, 239–249.10.1093/brain/awn275Suche in Google Scholar PubMed

Drew, M., Tippett, L.J., Starkey, N.J., and Isler, R.B. (2008). Executive dysfunction and cognitive impairment in a large community-based sample with multiple sclerosis form New Zealand: a descriptive study. Arch. Clin. Neuropsychol. 23, 1–19.10.1016/j.acn.2007.09.005Suche in Google Scholar

Dusankova, J.B., Kalincik, T., Havrdova, E., and Benedict, R.H. (2012). Cross cultural validation of the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) and the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Clin. Neuropsychol. 26, 1186–1200.10.1080/13854046.2012.725101Suche in Google Scholar PubMed

Edan, G., Kappos, L., Montalbán, X., Polman, C.H., Freedman, M.S., Hartung, H.P., Miller, D., Barkhof, F., Herrmann, J., Lanius, V., et al. (2014). Long-term impact of interferon β-1b in patients with CIS: 8-year follow-up of BENEFIT. J. Neurol. Neurosurg. Psychiatry 85, 1183–1189.10.1136/jnnp-2013-306222Suche in Google Scholar PubMed

Feuillet, L., Reuter, F., Audoin, B., Malikova, I., Barrau, K., Cherif, A.A., and Pelletier, J. (2007). Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis. Mult. Scler. 13, 124–127.10.1177/1352458506071196Suche in Google Scholar PubMed

Filippi, M., Rocca, M.A., Benedict, R.H., DeLuca, J., Geurts, J.J., Rombouts, S.A., Ron, M., and Comi, G. (2010). The contribution of MRI in assessing cognitive impairment in multiple sclerosis. Neurology 75, 2121–2128.10.1212/WNL.0b013e318200d768Suche in Google Scholar PubMed

Fink, F., Rischkau, E., Butt, M., Klein, J., Eling, P., and Hildebrandt, H. (2010). Efficacy of an executive function intervention programme in MS: a placebo-controlled and pseudo-randomized trial. Mult. Scler. 16, 1148–1151.10.1177/1352458510375440Suche in Google Scholar

Fischer, J.S., Priore, R.L., Jacobs, L.D., Cookfair, D.L., Rudick, R.A., Herndon, R.M., Richert, J.R., Salazar, A.M., Goodkin, D.E., Granger, C.V., et al. (2000). Neuropsychological effects of interferon beta-1a in relapsing multiple sclerosis. Ann. Neurol. 48, 885–892.10.1002/1531-8249(200012)48:6<885::AID-ANA9>3.0.CO;2-1Suche in Google Scholar PubMed

Ford-Johnson, L., DeLuca, J., Zhang, J., Elovic, E., Lengenfelder, J., and Chiaravalloti, N.D. (2016). Cognitive effects of modafinil in patients with multiple sclerosis: a clinical trial. Rehabil. Psychol. 61, 82–91.10.1037/a0039919Suche in Google Scholar PubMed

Frith, C. and Frith, U. (2005). Theory of mind. Curr. Biol. 15, R644–R646.10.1016/j.cub.2005.08.041Suche in Google Scholar

Frith, C.D. and Frith, U. (2012). Mechanisms of social cognition. Annu. Rev. Psychol. 63, 287–313.10.1146/annurev-psych-120710-100449Suche in Google Scholar PubMed

Gainotti, G. (2006). Measures of cognitive and emotional changes in multiple sclerosis and underlying models of brain dysfunction. J. Neurol. Sci. 245, 15–20.10.1016/j.jns.2005.09.013Suche in Google Scholar PubMed

Geisler, M.W., Sliwinski, M., Coyle, P.K., Masur, D.M., Doscher, C., and Krupp, L.B. (1996). The effects of amantadine and pemoline on cognitive functioning in multiple sclerosis. Arch. Neurol. 53, 185–188.10.1001/archneur.1996.00550020101021Suche in Google Scholar PubMed

Geurts, J.J., Calabrese, M., Fisher, E., and Rudick, R.A. (2012). Measurement and clinical effect of grey matter pathology in multiple sclerosis. Lancet Neurol. 11, 1082–1092.10.1016/S1474-4422(12)70230-2Suche in Google Scholar PubMed

Ghaffar, O., Reis, M., Pennell, N., O‘Connor, P., and Feinstein, A. (2010). APOE epsilon4 and the cognitive genetics of multiple sclerosis. Neurology 74, 1611–1618.10.1212/WNL.0b013e3181e074a7Suche in Google Scholar PubMed PubMed Central

Golan, D., Doniger, G.M., Wissemann, K., Zarif, M., Bumstead, B., Buhse, M., Fafard, L., Lavi, I., Wilken, J., and Gudesblatt, M. (2017). The impact of subjective cognitive fatigue and depression on cognitive function in patients with multiple sclerosis. Mult. Scler. 1, 1352458517695470.10.1177/1352458517695470Suche in Google Scholar PubMed

Goretti, B., Niccolai, C., Hakiki, B., Sturchio, A., Falautano, M., Minacapelli, E., Martinelli, V., Incerti, C., Nocentini, U., Murgia, M., et al. (2014). The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS): normative values with gender, age and education corrections in the Italian population. BMC Neurol. 14, 171.10.1186/s12883-014-0171-6Suche in Google Scholar PubMed PubMed Central

Goverover, Y., Chiaravalloti, N., and DeLuca, J. (2016). Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and performance of everyday life tasks: actual reality. Mult. Scler. 22, 544–550.10.1177/1352458515593637Suche in Google Scholar PubMed

Granberg, T., Martola, J., Bergendal, G., Shams, S., Damangir, S., Aspelin, P., Fredrikson, S., and Kristoffersen-Wiberg, M. (2015). Corpus callosum atrophy is strongly associated with cognitive impairment in multiple sclerosis: results of a 17-year longitudinal study. Mult. Scler. 21, 1151–1158.10.1177/1352458514560928Suche in Google Scholar PubMed

Guimarães, J. and Sá, M.J. (2012). Cognitive dysfunction in multiple sclerosis. Front. Neurol. 3, 74.10.3389/fneur.2012.00074Suche in Google Scholar PubMed PubMed Central

Hanssen, K.T., Beiske, A.G., Landrø, N.I., Hofoss, D., and Hessen, E. (2016). Cognitive rehabilitation in multiple sclerosis: a randomized controlled trial. Acta Neurol. Scand. 133, 30–40.10.1111/ane.12420Suche in Google Scholar PubMed

Harel, Y., Appleboim, N., Lavie, M., and Achiron, A. (2009). Single dose of methylphenidate improves cognitive performance in multiple sclerosis patients with impaired attention process. J. Neurol. Sci. 276, 38–40.10.1016/j.jns.2008.08.025Suche in Google Scholar PubMed

Hawellek, D.J., Hipp, J.F., Lewis, C.M., Corbetta, M., and Engel, A.K. (2011). Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis. Proc. Natl. Acad. Sci. USA 108, 19066–19071.10.1073/pnas.1110024108Suche in Google Scholar PubMed PubMed Central

Henry, J.D. and Beatty, W.W. (2006). Verbal fluency deficits in multiple sclerosis. Neuropsychologia 44, 1166–1174.10.1016/j.neuropsychologia.2005.10.006Suche in Google Scholar PubMed

Herndon, R.M. (2003). Multiple Sclerosis: Immunology, Pathology and Pathophysiology (New York: Demos Medical Publishing).Suche in Google Scholar

Hollenbach, J.A. and Oksenberg, J.R. (2015). The immunogenetics of multiple sclerosis: a comprehensive review. J. Autoimmun. 64, 13–25.10.1016/j.jaut.2015.06.010Suche in Google Scholar PubMed PubMed Central

Honan, C.A., Brown, R.F., and Batchelor, J. (2015). Perceived cognitive difficulties and cognitive test performance as predictors of employment outcomes in people with multiple sclerosis. J. Int. Neuropsychol. Soc. 21, 156–168.10.1017/S1355617715000053Suche in Google Scholar PubMed

Hosseini, B., Flora, D.B., Banwell, B.L., and Till, C. (2014). Age of onset as a moderator of cognitive decline in pediatric-onset multiple sclerosis. J. Int. Neuropsychol. Soc. 20, 796–804.10.1017/S1355617714000642Suche in Google Scholar PubMed

Huolman, S., Hämäläinen, P., Vorobyev, V., Ruutiainen, J., Parkkola, R., Laine, T., and Hämäläinen, H. (2011). The effects of rivastigmine on processing speed and brain activation in patients with multiple sclerosis and subjective cognitive fatigue. Mult. Scler. 17, 1351–1361.10.1177/1352458511412061Suche in Google Scholar PubMed

Iaffaldano, P., Viterbo, R.G., Paolicelli, D., Lucchese, G., Portaccio, E., Goretti, B., Direnzo, V., D‘Onghia, M., Zoccolella, S., Amato, M.P., et al. (2012). Impact of natalizumab on cognitive performances and fatigue in relapsing multiple sclerosis: a prospective, open-label, two years observational study. PLoS One 7, e35843.10.1371/journal.pone.0035843Suche in Google Scholar PubMed

Iaffaldano, P., Viterbo, R.G., and Trojano, M. (2016). Natalizumab discontinuation is associated with a rebound of cognitive impairment in multiple sclerosis patients. J. Neurol. 263, 1620–1625.10.1007/s00415-016-8177-1Suche in Google Scholar PubMed

Janculjak, D., Mubrin, A., Brinar, V., and Spilich, G. (2002). Changes of attention and memory in a group of patients with multiple sclerosis. Clin. Neurol. Neurosurg. 104, 221–227.10.1016/S0303-8467(02)00042-2Suche in Google Scholar

Jonkman, L.E., Rosenthal, D.M., Sormani, M.P., Miles, L., Herbert, J., Grossman, R.I., and Inglese, M. (2015) Gray matter correlates of cognitive performance differ between relapsing-remitting and primary-progressive multiple sclerosis. PLoS One 10, e0129380.10.1371/journal.pone.0129380Suche in Google Scholar PubMed

Kappos, L., Freedman, M.S., Polman, C.H., Edan, G., Hartung, H.P., Miller, D.H., Montalbán, X., Barkhof, F., Radü, E.W., Metzig, C., et al. (2009). Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial. Lancet Neurol. 8, 987–997.10.1016/S1474-4422(09)70237-6Suche in Google Scholar PubMed

Kappos, L., Wiendl, H., Selmaj, K., Arnold, D.L., Havrdova, E., Boyko, A., Kaufman, M., Rose, J., Greenberg, S., Sweetser, M., et al. (2015). Daclizumab HYP versus interferon beta-1a in relapsing multiple sclerosis. N. Engl. J. Med. 373, 1418–1428.10.1056/NEJMoa1501481Suche in Google Scholar PubMed

Keser, Z., Hasan, K.M., Mwangi, B., Gabr, R.E., and Nelson, F.M. (2017). Diffusion tensor imaging-defined sulcal enlargement is related to cognitive impairment in multiple sclerosis. J. Neuroimaging. 27, 312–317.10.1111/jon.12406Suche in Google Scholar PubMed

Khatri, B., Barkhof, F., Comi, G., Hartung, H.P., Kappos, L., Montalban, X., Pelletier, J., Stites, T., Wu, S., Holdbrook, F., et al. (2011). Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS Study. Lancet Neurol. 10, 520–529.10.1016/S1474-4422(11)70099-0Suche in Google Scholar PubMed

Kinner, M., Hoepner, R., Klotz, P., Prehn, C., Faissner, S., Salmen, A., Linker, R.A., Gold, R., and Chan, A. (2016). Immunotherapy improves cognitive function in secondary progressive multiple sclerosis. CNS Neurosci. Ther. 22, 1019–1022.10.1111/cns.12652Suche in Google Scholar PubMed PubMed Central

Koenig, K.A., Sakaie, K.E., Lowe, M.J., Lin, J., Stone, L., Bermel, R.A., Beall, E.B., Rao, S.M., Trapp, B.D., and Phillips, M.D. (2015). The relationship between cognitive function and high-resolution diffusion tensor MRI of the cingulum bundle in multiple sclerosis. Mult. Scler. 21, 1794–1801.10.1177/1352458515576983Suche in Google Scholar PubMed PubMed Central

Krupp, L.B., Christodoulou, C., Melville, P., Scherl, W.F., MacAllister, W.S., and Elkins, L.E. (2004). Donepezil improved memory in multiple sclerosis in a randomized clinical trial. Neurology 63, 1579–1585.10.1212/01.WNL.0000142989.09633.5ASuche in Google Scholar PubMed

Krupp, L.B., Christodoulou, C., Melville, P., Scherl, W.F., Pai, L.Y., Muenz, L.R., He, D., Benedict, R.H., Goodman, A., Rizvi, S., et al. (2011). Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis. Neurology 76, 1500–1507.10.1212/WNL.0b013e318218107aSuche in Google Scholar PubMed PubMed Central

Kujala, P., Portin, R., Revonsuo, A., and Ruutiainen, J. (1995). Attention related performance in two cognitively different subgroups of patients with multiple sclerosis. J. Neurol. Neurosurgery Psychiatry 59, 77–82.10.1136/jnnp.59.1.77Suche in Google Scholar PubMed PubMed Central

Lacy, M., Hauser, M., Pliskin, N., Assuras, S., Valentine, M.O., and Reder, A. (2013). The effects of long-term interferon-beta-1b treatment on cognitive functioning in multiple sclerosis: a 16-year longitudinal study. Mult. Scler. 19, 1765–1772.10.1177/1352458513485981Suche in Google Scholar PubMed

Langdon, D.W., Amato, M.P., Boringa, J., Brochet, B., Foley, F., Fredrikson, S., Hämäläinen, P., Hartung, H.P., Krupp, L., Penner, I.K., et al. (2012). Recommendations for a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Mult. Scler. 18, 891–898.10.1177/1352458511431076Suche in Google Scholar PubMed PubMed Central

Leclercq, E., Cabaret, M., Guilbert, A., Jougleux, C., Vermersch, P., and Moroni, C. (2014). The influence of age and illness duration on cognitive impairment in aging patients with relapsing-remitting multiple sclerosis (RR-MS). Geriatr. Psychol. Neuropsychiatr. Vieil. 12, 331–338.10.1684/pnv.2014.0482Suche in Google Scholar PubMed

Lincoln, N.B., Dent, A., Harding, J., Weyman, N., Nicholl, C., Blumhardt, L.D., and Playford, E.D. (2002). Evaluation of cognitive assessment and cognitive intervention for people with multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 72, 93–98.10.1136/jnnp.72.1.93Suche in Google Scholar PubMed PubMed Central

Lopes Costa, S., Gonçalves, O.F., DeLuca, J., Chiaravalloti, N., Chakravarthi, R., and Almeida, J. (2016). The temporal dynamics of visual processing in multiple sclerosis. Appl. Neuropsychol. Adult 23, 133–140.10.1080/23279095.2015.1020157Suche in Google Scholar PubMed

Lovera, J., Bagert, B., Smoot, K., Morris, C.D., Frank, R., Bogardus, K., Wild, K., Oken, B., Whitham, R., and Bourdette, D. (2007). Ginkgo biloba for the improvement of cognitive performance in multiple sclerosis: a randomized, placebo-controlled trial. Mult. Scler. 13, 376–385.10.1177/1352458506071213Suche in Google Scholar PubMed

Lovera, J.F., Frohman, E., Brown, T.R., Bandari, D., Nguyen, L., Yadav, V., Stuve, O., Karman, J., Bogardus, K., Heimburger, G., et al. (2010). Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial. Mult. Scler. 16, 715–723.10.1177/1352458510367662Suche in Google Scholar PubMed

Luerding, R., Gebel, S., Gebel, E.M., Schwab-Malek, S., and Weissert, R. (2016). Influence of formal education on cognitive reserve in patients with multiple sclerosis. Front. Neurol. 7, 46.10.3389/fneur.2016.00046Suche in Google Scholar PubMed PubMed Central

Martínez-Lapiscina, E.H., Fraga-Pumar, E., Gabilondo, I., Martínez-Heras, E., Torres-Torres, R., Ortiz-Pérez, S., Llufriu, S., Tercero, A., Andorra, M., Roca, M.F., et al. (2014). The multiple sclerosis visual pathway cohort: understanding neurodegeneration in MS. BMC Res. Notes 7, 910.10.1186/1756-0500-7-910Suche in Google Scholar PubMed PubMed Central

McCarthy, M., Beaumont, J.G., Thompson, R., and Peacock, S. (2005). Modalityspecific aspects of sustained and divided attentional performance in multiple sclerosis. Arch. Clin. Neuropsychol. 20, 705–718.10.1016/j.acn.2005.04.007Suche in Google Scholar PubMed

Meijer, K.A., Cercignani, M., Muhlert, N., Sethi, V., Chard, D., Geurts, J.J., and Ciccarelli, O. (2016). Patterns of white matter damage are non-random and associated with cognitive function in secondary progressive multiple sclerosis. Neuroimage Clin. 12, 123–131.10.1016/j.nicl.2016.06.009Suche in Google Scholar PubMed PubMed Central

Migliore, S., Ghazaryan, A., Simonelli, I., Pasqualetti, P., Landi, D., Palmieri, M.G., Moffa, F., Rinaldi, P., Vernieri, F., and Filippi, M.M. (2016). Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS) in the Italian population. Neurol. Sci. 37, 1261–1270.10.1007/s10072-016-2578-xSuche in Google Scholar PubMed

Mitolo, M., Venneri, A., Wilkinson, I.D., and Sharrack, B. (2015). Cognitive rehabilitation in multiple sclerosis: a systematic review. J. Neurol. Sci. 354, 1–9.10.1016/j.jns.2015.05.004Suche in Google Scholar PubMed

Mokhber, N., Azarpazhooh, A., Orouji, E., Rao, S.M., Khorram, B., Sahraian, M.A., Foroghipoor, M., Gharavi, M.M., Kakhi, S., Nikkhah, K., et al. (2014). Cognitive dysfunction in patients with multiple sclerosis treated with different types of interferon β: a randomized clinical trial. J. Neurol. Sci. 342, 16–20.10.1016/j.jns.2014.01.038Suche in Google Scholar PubMed

Mori, F., Kusayanagi, H., Buttari, F., Centini, B., Monteleone, F., Nicoletti, C.G., Bernardi, G., Di Cantogno, E.V., Marciani, M.G., and Centonze, D. (2012). Early treatment with high-dose interferon β-1a reverses cognitive and cortical plasticity deficits in multiple sclerosis. Funct. Neurol. 27, 163–168.Suche in Google Scholar

Moroso, A., Ruet, A., Lamargue-Hamel, D., Munsch, F., Deloire, M., Coupé, P., Ouallet, J.C., Planche, V., Moscufo, N., Meier, D.S., et al. (2017). Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 88, 146–151.10.1136/jnnp-2016-313867Suche in Google Scholar PubMed

Morrow, S.A., Smerbeck, A., Patrick, K., Cookfair, D., Weinstock-Guttman, B., andBenedict, R.H. (2009). Lisdexamfetamine dimesylate improves processing speed and memory in cognitively impaired MS patients: a phase II study. J. Neurol. 260, 489–497.10.1007/s00415-012-6663-7Suche in Google Scholar PubMed

Morrow, S.A., O’Connor, P.W., Polman, C.H., Goodman, A.D., Kappos, L., Lublin, F.D., Rudick, R.A., Jurgensen, S., Paes, D., Forrestal, F., et al. (2010). Evaluation of the symbol digit modalities test (SDMT) and MS neuropsychological screening questionnaire (MSNQ) in natalizumab-treated MS patients over 48 weeks. Mult. Scler. 16, 1385–1392.10.1177/1352458510378021Suche in Google Scholar PubMed

Motl, R.W., Sandroff, B.M., and Benedict, R.H. (2011). Cognitive dysfunction and multiple sclerosis: developing a rationale for considering the efficacy of exercise training. Mult. Scler. 17, 1034–1040.10.1177/1352458511409612Suche in Google Scholar PubMed

Nocentini, U., Pasqualetti, P., Bonavita, S., Buccafusca, M., De Caro, M.F., Farina, D., Girlanda, P., Le Pira, F., Lugaresi, A., Quattrone, A., et al. (2006). Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. Mult. Scler. 12, 77–87.10.1191/135248506ms1227oaSuche in Google Scholar PubMed

Nourbakhsh, B., Nunan-Saah, J., Maghzi, A.H., Julian, L.J., Spain, R., Jin, C., Lazar, A., Pelletier, D., and Waubant E. (2016). Longitudinal associations between MRI and cognitive changes in very early MS. Mult. Scler. Relat. Disord. 5, 47–52.10.1016/j.msard.2015.10.010Suche in Google Scholar PubMed

Nunnari, D., De Cola, M.C., D’Aleo, G., Rifici, C., Russo, M., Sessa, E., Bramanti, P., and Marino, S. (2015) Impact of depression, fatigue, and global measure of cortical volume on cognitive impairment in multiple sclerosis. Biomed. Res. Int. 2015, 519785.10.1155/2015/519785Suche in Google Scholar PubMed PubMed Central

Oken, B.S., Kishiyama, S., Zajdel, D., Bourdette, D., Carlsen, J., Haas, M., Hugos, C., Kraemer, D.F., Lawrence, J., and Mass, M. (2004). Randomized controlled trial of yoga and exercise in multiple sclerosis. Neurology 62, 2058–2064.10.1212/01.WNL.0000129534.88602.5CSuche in Google Scholar PubMed

Papathanasiou, A., Messinis, L., Zampakis, P., Panagiotakis, G., Gourzis, P., Georgiou, V., and Papathanasopoulos, P. (2015) Thalamic atrophy predicts cognitive impairment in relapsing remitting multiple sclerosis. Effect on instrumental activities of daily living and employment status. J. Neurol. Sci. 358, 236–242.10.1016/j.jns.2015.09.001Suche in Google Scholar PubMed

Patanella, A.K., Zinno, M., Quaranta, D., Nociti, V., Frisullo, G., Gainotti, G., Tonali, P.A., Batocchi, A.P., and Marra, C. (2010). Correlations between peripheral blood mononuclear cell production of BDNF, TNF-α, IL-6, IL-10 and cognitive performances in multiple sclerosis patients. J. Neurosci. Res. 88, 1106–1112.10.1002/jnr.22276Suche in Google Scholar PubMed

Patten, S.B., Beck, C.A., Williams, J.V., Barbui, C., and Metz, L.M. (2003). Major depression in multiple sclerosis: a population-based perspective. Neurology 61, 1524–1527.10.1212/01.WNL.0000095964.34294.B4Suche in Google Scholar PubMed

Patti, F., Morra, V.B., Amato, M.P., Trojano, M., Bastianello, S., Tola, M.R., Cottone, S., Plant, A., Picconi, O., and COGIMUS Study Group. (2013). Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study. PLoS One 8, e74111.10.1371/journal.pone.0074111Suche in Google Scholar PubMed PubMed Central

Pelosi, L., Geesken, J.M., Holly, M., Hayward, M., and Blumhardt, L.D. (1997). Working memory impairment in early multiple-sclerosis. Evidence from an event-related potential study of patients with clinically isolated myelopathy. Brain 120, 2039–2058.10.1093/brain/120.11.2039Suche in Google Scholar PubMed

Penner, I.K., Opwis, K., and Kappos, L. (2007). Relation between functional brain imaging, cognitive impairment and cognitive rehabilitation in patients with multiple sclerosis. J. Neurol. 254(Suppl. 2), II53–II57.10.1007/s00415-007-2013-6Suche in Google Scholar PubMed

Penner, I.K., Raselli, C., Stöcklin, M., Opwis, K., Kappos, L., and Calabrese, P. (2009). The Fatigue Scale for Motor and Cognitive Functions (FSMC): validation of a new instrument to assess multiple sclerosis-related fatigue. Mult. Scler. 15, 1509–1517.10.1177/1352458509348519Suche in Google Scholar PubMed

Penner, I.K., Stemper, B., Calabrese, P., Freedman, M.S., Polman, C.H., Edan, G., Hartung, H.P., Miller, D.H., Montalbán, X., Barkhof, F., et al. (2012). Effects of interferon β-1b on cognitive performance in patients with a first event suggestive of multiple sclerosis. Mult. Scler. 18, 1466–1471.10.1177/1352458512442438Suche in Google Scholar PubMed PubMed Central

Peyro Saint Paul, L., Creveuil, C., Heinzlef, O., De Seze, J., Vermersch, P., Castelnovo, G., Cabre, P., Debouverie, M., Brochet, B., Dupuy, B., et al. (2016). Efficacy and safety profile of memantine in patients with cognitive impairment in multiple sclerosis: a randomized, placebo-controlled study. J. Neurol. Sci. 363, 69–76.10.1016/j.jns.2016.02.012Suche in Google Scholar PubMed

Peyser, J.M., Rao, S.M., LaRocca, N.G., and Kaplan, E. (1990). Guidelines for neuropsychological research in multiple sclerosis. Arch. Neurol. 47, 94–97.10.1001/archneur.1990.00530010120030Suche in Google Scholar PubMed

Piras, M.R., Magnano, I., Canu, E.D., Paulus, K.S., Satta, W.M., Soddu, A., Conti, M., Achene, A., Solinas, G., and Aiello, I. (2003). Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings. J. Neurol. Neurosurg. Psychiatry 74, 878–885.10.1136/jnnp.74.7.878Suche in Google Scholar PubMed PubMed Central

Planche, V., Gibelin, M., Cregut, D., Pereira, B., and Clavelou, P. (2016). Cognitive impairment in a population-based study of patients with multiple sclerosis: differences between late relapsing-remitting, secondary progressive and primary progressive multiple sclerosis. Eur. J. Neurol. 23, 282–289.10.1111/ene.12715Suche in Google Scholar PubMed

Polychroniadou, E., Bakirtzis, C., Langdon, D., Lagoudaki, R., Kesidou, E., Theotokis, P., Tsalikakis, D., Poulatsidou, K., Kyriazis, O., Boziki, M., et al. (2016). Validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in Greek population with multiple sclerosis. Mult. Scler. Relat. Disord. 9, 68–72.10.1016/j.msard.2016.06.011Suche in Google Scholar PubMed

Portaccio, E., Stromillo, M.L., Goretti, B., Hakiki, B., Giorgio, A., Rossi, F., De Leucio, A., De Stefano, N., and Amato, M.P. (2013). Natalizumab may reduce cognitive changes and brain atrophy rate in relapsing-remitting multiple sclerosis – a prospective, non-randomized pilot study. Eur. J. Neurol. 20, 986–990.10.1111/j.1468-1331.2012.03882.xSuche in Google Scholar PubMed

Potagas, C., Giogkaraki, E., Koutsis, G., Mandellos, D., Tsirempolou, E., Sfagos, C., and Vassilopoulos, D. (2008). Cognitive impairment in different MS subtypes and clinically isolated syndromes. J. Neurol. Sci. 267, 100–106.10.1016/j.jns.2007.10.002Suche in Google Scholar PubMed

Pöttgen, J., Dziobek, I., Reh, S., Heesen, C., and Gold, S.M. (2013). Impaired social cognition in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 84, 523–528.10.1136/jnnp-2012-304157Suche in Google Scholar PubMed

Pozzilli, C., Passafiume, D., Bernardi, S., Pantano, P., Incoccia, C., Bastianello, S., Bozzao, L., Lenzi, G.L., and Fieschi, C. (1991). SPECT, MRI and cognitive functions in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 54, 110–115.10.1136/jnnp.54.2.110Suche in Google Scholar PubMed

Preziosa, P., Rocca, M.A., Pagani, E., Stromillo, M.L., Enzinger, C., Gallo, A. Hulst, H.E., Atzori, M., Pareto, D., Riccitelli, G.C., et al. (2016). Structural MRI correlates of cognitive impairment in patients with multiple sclerosis: a multicenter study. Hum. Brain Mapp. 37, 1627–1644.10.1002/hbm.23125Suche in Google Scholar PubMed

Rao, S.M. (1986). Neuropsychology of multiple sclerosis: a critical review. J. Clin. Exp. Neuropsychol. 8, 503–542.10.1080/01688638608405173Suche in Google Scholar PubMed

Rao, S.M. and Cognitive Function Study Group, National Multiple Sclerosis Society. (1990). A manual for the Brief Repeatable Battery of Neuropsychological Tests in multiple sclerosis. (New York: National Multiple Sclerosis Society).Suche in Google Scholar

Rao, S.M., Leo, G.J., and St. Aubin-Faubert, P. (1989). On the nature of memory disturbance in multiple sclerosis. J. Clin. Exp. Neuropsychol. 11: 699–712.10.1080/01688638908400926Suche in Google Scholar PubMed

Rao, S., Leo, G., Bernardin, L., and Unverzagt, F. (1991). Cognitive dysfunction in multiple sclerosis: frequency, patterns, and predictions. Neurology 41, 685–691.10.1212/WNL.41.5.685Suche in Google Scholar

Rocca, M.A., Valsasina, P., Hulst, H.E., Abdel-Aziz, K., Enzinger, C., Gallo, A., Pareto, D., Riccitelli, G., Muhlert, N., Ciccarelli, O., et al. (2014). Functional correlates of cognitive dysfunction in multiple sclerosis: a multicenter fMRI study. Hum. Brain Mapp. 35, 5799–5814.10.1002/hbm.22586Suche in Google Scholar PubMed

Rocca, M.A., Amato, M.P., De Stefano, N., Enzinger, C., Geurts, J.J., Penner, I.K., Rovira, A., Sumowski, J.F., Valsasina, P., Filippi, M., et al. (2015). Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis. Lancet Neurol. 14, 302–317.10.1016/S1474-4422(14)70250-9Suche in Google Scholar PubMed

Rojas, J.I., Patrucco, L., Miguez, J., and Cristiano, E. (2016). Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact. Arq. Neuropsiquiatr. 74, 235–243.10.1590/0004-282X20160015Suche in Google Scholar PubMed

Roosendaal, S.D., Geurts, J.J., Vrenken, H., Hulst, H.E., Cover, K.S., Castelijns, J.A., Pouwels, P.J., and Barkhof, F. (2009). Regional DTI differences in multiple sclerosis patients. Neuroimage 44, 1397–1403.10.1016/j.neuroimage.2008.10.026Suche in Google Scholar PubMed

Roosendaal, S.D., Moraal, B., Vrenken, H., Castelijns, J.A., Pouwels, P.J., Barkhof, F., and Geurts, J.J. (2008). In vivo MR imaging of hippocampal lesions in multiple sclerosis. J. Magn. Reson. Imaging. 27, 726–731.10.1002/jmri.21294Suche in Google Scholar PubMed

Rosti-Otajärvi, E.M. and Hämäläinen, P.I. (2014). Neuropsychological rehabilitation for multiple sclerosis. Cochrane Database of Systematic Reviews, Issue 2. Art. No.: CD009131.10.1002/14651858.CD009131.pub3Suche in Google Scholar PubMed

Ruet, A., Deloire, M., Charré-Morin, J., Hamel, D., and Brochet, B. (2013a). Cognitive impairment differs between primary progressive and relapsing-remitting MS. Neurology 80, 1501–1508.10.1212/WNL.0b013e31828cf82fSuche in Google Scholar PubMed

Ruet, A., Deloire, M., Hamel, D., Ouallet, J.C., Petry, K., and Brochet, B. (2013b). Cognitive impairment, health related quality of life and vocational status at early stages of multiple sclerosis: a 7-year longitudinal study. J. Neurol. 260, 776–784.10.1007/s00415-012-6705-1Suche in Google Scholar PubMed

Sacco, R., Bisecco, A., Corbo, D., Della Corte, M., d’Ambrosio, A., Docimo, R., Gallo, A., Esposito, F., Esposito, S., Cirillo, M., et al. (2015). Cognitive impairment and memory disorders in relapsing-remitting multiple sclerosis: the role of white matter, gray matter and hippocampus. J. Neurol. 262, 1691–1697.10.1007/s00415-015-7763-ySuche in Google Scholar PubMed

Sailer, M., Heinze, H.J., Schoenfeld, M.A., Hauser, U., and Smid, H.G. (2000). Amantadine influences cognitive processing in patients with multiple sclerosis. Pharmacopsychiatry 33, 28–37.10.1055/s-2000-7966Suche in Google Scholar PubMed

Sandi, D., Rudisch, T., Füvesi, J., Fricska-Nagy, Z., Huszka, H., Biernacki, T., Langdon, D.W., Langane, É., Vécsei, L., and Bencsik, K. (2015). The Hungarian validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery and the correlation of cognitive impairment with fatigue and quality of life. Mult. Scler. Relat. Disord. 4, 499–504.10.1016/j.msard.2015.07.006Suche in Google Scholar PubMed

Sandroff, B.M., Johnson, C.L., and Motl, R.W. (2017). Exercise training effects on memory and hippocampal viscoelasticity in multiple sclerosis: a novel application of magnetic resonance elastography. Neuroradiology 59, 61–67.10.1007/s00234-016-1767-xSuche in Google Scholar PubMed

Santos, T., Pinheiro, J., and Barros, P. (2015). Cognitive Impairment in Multiple Sclerosis. Eur. Neurol. Rev. 10, 157–163.10.17925/ENR.2015.10.02.157Suche in Google Scholar

Schoonheim, M.M., Geurts, J.J., and Barkhof, F. (2010). The limits of functional reorganization in multiple sclerosis. Neurology 74, 1246–1247.10.1212/WNL.0b013e3181db9957Suche in Google Scholar PubMed

Schoonheim, M.M., Geurts, J.J., Landi, D., Douw, L., van der Meer, M.L., Vrenken, H., Polman, C.H., Barkhof, F., and Stam, C.J. (2013). Functional connectivity changes in multiple sclerosis patients: a graph analytical study of MEG resting state data. Hum. Brain Mapp. 34, 52–61.10.1002/hbm.21424Suche in Google Scholar PubMed PubMed Central

Schoonheim, M.M., Meijer, K.A., and Geurts, J.J. (2015). Network collapse and cognitive impairment in multiple sclerosis. Front. Neurol. 6, 82.10.3389/fneur.2015.00082Suche in Google Scholar PubMed PubMed Central

Schoonheim, M.M., Vigeveno, R.M., Rueda Lopes, F.C., Pouwels, P.J., Polman, C.H., Barkhof, F., and Geurts, J.J. (2014). Sex-specific extent and severity of white matter damage in multiple sclerosis: implications for cognitive decline. Hum. Brain Mapp. 35, 2348–2358.10.1002/hbm.22332Suche in Google Scholar PubMed PubMed Central

Schwid, S.R., Goodman, A.D., Weinstein, A., McDermott, M.P., Johnson, K.P., and Copaxone Study Group. (2007). Cognitive function in relapsing multiple sclerosis: minimal changes in a 10-year clinical trial. J. Neurol. Sci. 255, 57–63.10.1016/j.jns.2007.01.070Suche in Google Scholar PubMed

Shatil, E., Metzer, A., Horvitz, O., and Miller, A. (2010). Home-based personalized cognitive training in MS patients: a study of adherence and cognitive performance. NeuroRehabil. 26, 143–153.10.3233/NRE-2010-0546Suche in Google Scholar PubMed

Shi, J., Tu, J.L., Gale, S.D., Baxter, L., Vollmer, T.L., Campagnolo, D.I., Tyry, T.M., Zhuang, Y., and Kuniyoshi, S.M. (2011). APOE ε4 is associated with exacerbation of cognitive decline in patients with multiple sclerosis. Cogn. Behav. Neurol. 24, 128–133.10.1097/WNN.0b013e31823380b5Suche in Google Scholar PubMed

Shkil‘niuk, G.G., Il‘ves, A.G., Prakhova, L.N., Kataeva, G.V., and Stolirov, I.D. (2013). PET-patterns of cognitive impairment in patients with multiple sclerosis. Zh. Nevrol. Psikhiatr. Im. S S Korsakova 113, 53–56.Suche in Google Scholar PubMed

Siegert, R.J. and Abernethy, D.A. (2005). Depression in multiple sclerosis: a review. J. Neurol. Neurosurg. Psychiatry. 76, 469–475.10.1136/jnnp.2004.054635Suche in Google Scholar PubMed PubMed Central

Staples, D. and Lincoln, N.B. (1979). Intellectual impairment in multiple sclerosis and its relation to functional abilities. Rheumatol. Rehabil. 18, 153–160.10.1093/rheumatology/18.3.153Suche in Google Scholar PubMed

Strober, L., Englert, J., Munschauer, F., Weinstock-Guttman, B., Rao, S., and Benedict, R.H. (2009). Sensitivity of conventional memory tests in multiple sclerosis: comparing the Rao Brief Repeatable Neuropsychological Battery and the Minimal Assessment of Cognitive Function in MS. Mult. Scler. 15, 1077–1084.10.1177/1352458509106615Suche in Google Scholar PubMed

Sumowski, J.F. and Leavitt, V.M. (2013). Cognitive reserve in multiple sclerosis. Mult. Scler. 19, 1122–1127.10.1177/1352458513498834Suche in Google Scholar PubMed

Sundgren, M., Piehl, F., Wahlin, Å., and Brismar, T. (2016). Cognitive function did not improve after initiation of natalizumab treatment in relapsing-remitting multiple sclerosis. A prospective one-year dual control group study. Mult. Scler. Relat. Disord. 10, 36–43.10.1016/j.msard.2016.08.011Suche in Google Scholar PubMed

Thornton, A.E., Raz, N., and Tucke, K.A. (2002). Memory in multiple sclerosis: contextual encoding deficits. J. Int. Neuropsychol. 8, 395–409.10.1017/S1355617702813200Suche in Google Scholar PubMed

Triche, E.W., Ruiz, J.A., Olson, K.M., and Lo, A.C. (2016). Changes in cognitive processing speed, mood, and fatigue in an observational study of persons with multiple sclerosis treated with dalfampridine-ER. Clin. Neuropharmacol. 39, 73–80.10.1097/WNF.0000000000000130Suche in Google Scholar PubMed

van Munster, C.E., Jonkman, L.E., Weinstein, H.C., Uitdehaag, B.M., and Geurts, J.J. (2015). Gray matter damage in multiple sclerosis: impact on clinical symptoms. Neuroscience 303, 446–461.10.1016/j.neuroscience.2015.07.006Suche in Google Scholar PubMed

Van Schependom, J., Gielen, J., Laton, J., D’hooghe, M.B., De Keyser, J., and Nagels, G. (2014). Graph theoretical analysis indicates cognitive impairment in MS stems from neural disconnection. Neuroimage Clin. 4, 403–410.10.1016/j.nicl.2014.01.012Suche in Google Scholar PubMed PubMed Central

Van Schependom, J., D‘hooghe, M.B., Cleynhens, K., D’hooge, M., Haelewyck, M.C., De Keyser, J., and Nagels, G. (2015). Reduced information processing speed as primum movens for cognitive decline in MS. Mult. Scler. 21, 83–91.10.1177/1352458514537012Suche in Google Scholar PubMed

Vleugels, L., Lafosse, C., van Nunen, A., Nachtergaele, S., Ketelaer, P., Charlier, M., and Vandenbussche, E. (2000). Visuospatial impairment in multiple sclerosis patients diagnosed with neuropsychological tasks. Mult. Scler. 6, 241–254.10.1191/135245800678827879Suche in Google Scholar

Vogt, A., Kappos, L., Calabrese, P., Stocklin, M., Gschwind, L., Opwis, K., and Penner, I.K. (2009). Working memory training in patients with multiple sclerosis – comparison of two different training schedules. Restor. Neurol. Neurosci. 27, 225–235.10.3233/RNN-2009-0473Suche in Google Scholar PubMed

Waxman, S.G. (1982). Membranes, myelin, and the pathophysiology of multiple sclerosis. N. Engl. J. Med. 306, 1529–1533.10.1056/NEJM198206243062505Suche in Google Scholar PubMed

Wegener, S., Marx, I., and Zettl, U.K. (2013). Cognitive deficits and dementia in patients with multiple sclerosis: status quo and open questions. Fortschr. Neurol. Psychiatr. 81, 639–647.10.1055/s-0033-1355497Suche in Google Scholar PubMed

Weinstein, A., Schwid, S.I.L., Schiffer, R.B., McDermott, M.P., Giang, D.W., and Goodman, A.D. (1999). Neuropsychologic status in multiple sclerosis after treatment with Glatiramer. Arch. Neurol. 56, 319–324.10.1001/archneur.56.3.319Suche in Google Scholar PubMed

Weinstock-Guttman, B., Benedict, R.H., Tamaño-Blanco, M., Ramasamy, D.P., Stosic, M., Polito, J., Zivadinov, R., and Ramanathan, M. (2011). The rs2030324 SNP of brain-derived neurotrophic factor (BDNF) is associated with visual cognitive processing in multiple sclerosis. Pathophysiology 18, 43–52.10.1016/j.pathophys.2010.04.005Suche in Google Scholar PubMed

Weinstock-Guttman, B., Galetta, S.L., Giovannoni, G., Havrdova, E., Hutchinson, M., Kappos, L., O’Connor, P.W., Phillips, J.T., Polman, C., Stuart, W.H., et al. (2012). Additional efficacy endpoints from pivotal natalizumab trials in relapsing-remitting MS. J. Neurol. 259, 898–905.10.1007/s00415-011-6275-7Suche in Google Scholar PubMed

Wilken, J., Kane, R.L., Sullivan., C.L., Gudesblatt, M., Lucas, S., Fallis, R., You, X., and Foulds, P. (2013). Changes in fatigue and cognition in patients with relapsing forms of multiple sclerosis treated with natalizumab: the ENER-G study. Int. J. MS Care. 15, 120–128.10.7224/1537-2073.2012-043Suche in Google Scholar PubMed PubMed Central

Winkelmann, A., Engel, C., Apel, A., and Zettl, U.K. (2007). Cognitive impairment in multiple sclerosis. J. Neurol. 254(Suppl. 2), II35–II42.10.1007/s00415-007-2010-9Suche in Google Scholar PubMed

Zipoli, V., Goretti, B., Hakiki, B., Siracusa, G., Sorbi, S., Portaccio, E., and Amato, M.P. (2010). Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes. Mult. Scler. 16, 62–67.10.1177/1352458509350311Suche in Google Scholar PubMed

Received: 2017-2-8
Accepted: 2017-5-19
Published Online: 2017-8-8
Published in Print: 2017-11-27

©2017 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 26.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/revneuro-2017-0011/pdf
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