Abstract
A number of limitations associated with the use of hollow nerve guidance conduits (NGCs) require further discussion. Most importantly, the functional recovery outcomes after the placement of hollow NGCs are poor even after the successful bridging of peripheral nerve injuries. However, nerve regeneration scaffolds built using electric spinning have several advantages that may improve functional recovery. Thus, the present study summarizes recent developments in this area, including the key cells that are combined with the scaffold and associated with nerve regeneration, the structure and configuration of the electrospinning design (which determines the performance of the electrospinning scaffold), the materials the electrospinning fibers are composed of, and the methods used to control the morphology of a single fiber. Additionally, this study also discusses the processes underlying peripheral nerve regeneration. The primary goals of the present review were to evaluate and consolidate the findings of studies that used scaffolding biomaterials built by electrospinning used for peripheral nerve regeneration support. It is amazing that the field of peripheral nerve regeneration continues to consistently produce such a wide variety of innovative techniques and novel types of equipment, because the introduction of every new process creates an opportunity for advances in materials for nerve repair.
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: 51073024
Award Identifier / Grant number: 51273021
Funding statement: The authors received funding from the National Natural Science Foundation of China (51073024, 51273021), 973 (2014CB542201 and 2012CB518106), the Special Project of the ‘Thirteenth Five-year Plan’ for medical Science Development of PLA (BWS13C029), and the Special Project of the ‘Twelfth–Five-year Plan’ for medical Science Development of PLA (BWS11J025).
Acknowledgments
The authors received funding from the National Natural Science Foundation of China (51073024, 51273021), 973 (2014CB542201 and 2012CB518106), the Special Project of the ‘Thirteenth Five-year Plan’ for medical Science Development of PLA (BWS13C029), and the Special Project of the ‘Twelfth–Five-year Plan’ for medical Science Development of PLA (BWS11J025).
Conflict of interest statement: The authors declare that they have no conflict of interest.
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©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis
- Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases
- Developmental implications of children’s brain networks and learning
- Neural substrates and potential treatments for levodopa-induced dyskinesias in Parkinson’s disease
- Treatment of trigeminal neuralgia by radiofrequency of the Gasserian ganglion
- S100B raises the alert in subarachnoid hemorrhage
- Use of electrospinning to construct biomaterials for peripheral nerve regeneration
Articles in the same Issue
- Frontmatter
- Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis
- Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases
- Developmental implications of children’s brain networks and learning
- Neural substrates and potential treatments for levodopa-induced dyskinesias in Parkinson’s disease
- Treatment of trigeminal neuralgia by radiofrequency of the Gasserian ganglion
- S100B raises the alert in subarachnoid hemorrhage
- Use of electrospinning to construct biomaterials for peripheral nerve regeneration